ID   GDPP1_XENTR             Reviewed;         399 AA.
AC   Q0V9F1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=GDP-D-glucose phosphorylase 1;
DE            EC=2.7.7.78;
GN   Name=gdpgp1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specific and highly efficient GDP-D-glucose phosphorylase
CC       regulating the levels of GDP-D-glucose in cells. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate
CC         + GDP + H(+); Xref=Rhea:RHEA:30387, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:62230; EC=2.7.7.78;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GDPGP1 family. {ECO:0000305}.
CC   -!- CAUTION: The ortholog in A.thaliana catalyzes the first reaction of the
CC       Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in
CC       plants. {ECO:0000305}.
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DR   EMBL; BC121598; AAI21599.1; -; mRNA.
DR   RefSeq; NP_001072398.1; NM_001078930.1.
DR   AlphaFoldDB; Q0V9F1; -.
DR   PaxDb; Q0V9F1; -.
DR   DNASU; 779852; -.
DR   Ensembl; ENSXETT00000028398; ENSXETP00000028398; ENSXETG00000012962.
DR   GeneID; 779852; -.
DR   KEGG; xtr:779852; -.
DR   CTD; 390637; -.
DR   Xenbase; XB-GENE-5867391; gdpgp1.
DR   eggNOG; KOG2720; Eukaryota.
DR   HOGENOM; CLU_041964_2_1_1; -.
DR   InParanoid; Q0V9F1; -.
DR   OMA; GIRVILW; -.
DR   OrthoDB; 1178383at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000012962; Expressed in egg cell and 11 other tissues.
DR   ExpressionAtlas; Q0V9F1; baseline.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0080048; F:GDP-D-glucose phosphorylase activity; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; ISS:UniProtKB.
DR   InterPro; IPR026506; GDPGP.
DR   PANTHER; PTHR20884; PTHR20884; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Guanine-nucleotide releasing factor; Hydrolase;
KW   Nucleotide-binding; Nucleotidyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..399
FT                   /note="GDP-D-glucose phosphorylase 1"
FT                   /id="PRO_0000336755"
FT   ACT_SITE        236
FT                   /note="Tele-GMP-histidine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   399 AA;  45086 MW;  F314846EFFCDEC9E CRC64;
     MEEHRKLLPN ATVEEYNYFE EDFVFQGLSW KKRQEFAEDT SFLSPFDKAL QSKWEEKMNE
     GLFRYPLRNV QTKILPGSVS YVAQLNIQRS INRRKPEDIW SVQQKFNPNQ FNYNKIKSEE
     IVFQMIRSEA EHSVDSHIVQ GSMVNGMGSS ECKSGSTPQG SCTLECKSSC TLVVINVSPL
     EFGHVLFMPD PSLCLPQILT ENLMLFGMES VFLSSHPGFR VGFNSLGGFA SVNHLHLHGF
     YLDHELLIES SCSKPLCPEI NFHLVTHFPA PGFLFYTDGK DLKSTAQKIC KVTDFLVAKN
     IAHNLFVTRG SNPDTGKVSE DRNGIRVIIW ARKPSFGAKE VSAFNVALCE LAGHLPVKNQ
     EDFISITEDS VIAIIHSCLL ADDEFTQLSL DLVQHLRKQ