GDS1_DROME
ID GDS1_DROME Reviewed; 635 AA.
AC A1Z6S7; A1Z6S6; O44116; Q86LF4; Q8T996;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=GTPase-GDP dissociation stimulator vimar {ECO:0000305};
GN Name=vimar {ECO:0000312|FlyBase:FBgn0022960};
GN Synonyms=l(2)k16722 {ECO:0000312|FlyBase:FBgn0022960};
GN ORFNames=CG3572 {ECO:0000312|FlyBase:FBgn0022960};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|EMBL:AAB87984.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=9533953; DOI=10.1016/s0925-4773(98)00016-1;
RA Lo P.C., Frasch M.;
RT "bagpipe-Dependent expression of vimar, a novel Armadillo-repeats gene, in
RT Drosophila visceral mesoderm.";
RL Mech. Dev. 72:65-75(1998).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000312|EMBL:AAL40010.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL40010.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:AAL40010.1};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5] {ECO:0000312|EMBL:AAO47869.1, ECO:0000312|EMBL:ACI15753.1, ECO:0000312|EMBL:ADX35945.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAO47869.1, ECO:0000312|EMBL:ACI15753.1,
RC ECO:0000312|EMBL:ADX35945.1}; TISSUE=Embryo {ECO:0000312|EMBL:AAO47869.1};
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.,
RA Booth B.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000305}
RP FUNCTION, INTERACTION WITH MIRO, SUBCELLULAR LOCATION, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=27716788; DOI=10.1371/journal.pgen.1006359;
RA Ding L., Lei Y., Han Y., Li Y., Ji X., Liu L.;
RT "Vimar Is a Novel Regulator of Mitochondrial Fission through Miro.";
RL PLoS Genet. 12:e1006359-e1006359(2016).
CC -!- FUNCTION: Probably acts as a GEF (guanine nucleotide exchange factor)
CC for the Rho family of small GTP-binding proteins (G proteins) that
CC stimulates the dissociation of GDP to enable subsequent binding of GTP
CC (By similarity). May also chaperone the processing and/or trafficking
CC of small GTPases independently of GEF activity (By similarity). By
CC interacting with Miro, promotes mitochondrial fission in response to
CC high calcium concentrations (PubMed:27716788).
CC {ECO:0000250|UniProtKB:P52306, ECO:0000269|PubMed:27716788}.
CC -!- SUBUNIT: Interacts with Miro. {ECO:0000269|PubMed:27716788}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000269|PubMed:27716788}. Mitochondrion
CC {ECO:0000269|PubMed:27716788}. Cytoplasm, cytosol
CC {ECO:0000269|PubMed:27716788}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the mesoderm during embryogenesis.
CC {ECO:0000269|PubMed:9533953}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown perturbs mitochondrial
CC distribution and dynamics. {ECO:0000269|PubMed:27716788}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL40010.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF034421; AAB87984.1; -; mRNA.
DR EMBL; AE013599; AAS64794.1; -; Genomic_DNA.
DR EMBL; AE013599; AAF57418.1; -; Genomic_DNA.
DR EMBL; BT004891; AAO47869.1; -; mRNA.
DR EMBL; AY069865; AAL40010.1; ALT_INIT; mRNA.
DR EMBL; BT044558; ACI15753.1; -; mRNA.
DR EMBL; BT125966; ADX35945.1; -; mRNA.
DR RefSeq; NP_477305.1; NM_057957.5.
DR RefSeq; NP_995767.1; NM_206045.2.
DR AlphaFoldDB; A1Z6S7; -.
DR SMR; A1Z6S7; -.
DR IntAct; A1Z6S7; 15.
DR STRING; 7227.FBpp0085514; -.
DR PaxDb; A1Z6S7; -.
DR PeptideAtlas; A1Z6S7; -.
DR DNASU; 35609; -.
DR EnsemblMetazoa; FBtr0086182; FBpp0085514; FBgn0022960.
DR EnsemblMetazoa; FBtr0086183; FBpp0089175; FBgn0022960.
DR GeneID; 35609; -.
DR KEGG; dme:Dmel_CG3572; -.
DR UCSC; CG3572-RC; d. melanogaster.
DR CTD; 35609; -.
DR FlyBase; FBgn0022960; vimar.
DR VEuPathDB; VectorBase:FBgn0022960; -.
DR eggNOG; KOG4500; Eukaryota.
DR GeneTree; ENSGT00390000014293; -.
DR HOGENOM; CLU_021124_0_0_1; -.
DR InParanoid; A1Z6S7; -.
DR OMA; IAWLINN; -.
DR OrthoDB; 561489at2759; -.
DR PhylomeDB; A1Z6S7; -.
DR BioGRID-ORCS; 35609; 0 hits in 1 CRISPR screen.
DR ChiTaRS; vimar; fly.
DR GenomeRNAi; 35609; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0022960; Expressed in wing disc and 36 other tissues.
DR ExpressionAtlas; A1Z6S7; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; HDA:FlyBase.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IGI:UniProtKB.
DR GO; GO:0046716; P:muscle cell cellular homeostasis; IMP:FlyBase.
DR GO; GO:1901215; P:negative regulation of neuron death; IMP:FlyBase.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0010821; P:regulation of mitochondrion organization; IGI:UniProtKB.
DR GO; GO:0042052; P:rhabdomere development; IMP:FlyBase.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR040144; RAP1GDS1.
DR PANTHER; PTHR10957; PTHR10957; 1.
DR SMART; SM00185; ARM; 4.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Endoplasmic reticulum; Guanine-nucleotide releasing factor;
KW Mitochondrion; Reference proteome; Repeat.
FT CHAIN 1..635
FT /note="GTPase-GDP dissociation stimulator vimar"
FT /id="PRO_0000455599"
FT REPEAT 72..118
FT /note="ARM 1"
FT /evidence="ECO:0000255"
FT REPEAT 346..391
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 392..432
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REPEAT 510..550
FT /note="ARM 4"
FT /evidence="ECO:0000255"
FT CONFLICT 1..4
FT /note="MATA -> MAT (in Ref. 5; AAF57418/ADX35945 and 1;
FT AAB87984)"
FT /evidence="ECO:0000305"
FT CONFLICT 218
FT /note="S -> A (in Ref. 1; AAB87984 and 4; AAL40010)"
FT /evidence="ECO:0000305"
FT CONFLICT 621
FT /note="E -> G (in Ref. 5; AAO47869)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 635 AA; 70325 MW; 4027B8623F4AC3BE CRC64;
MATAEIDDLI EKLKTTSVSP ANTTNLLCEI SATKDPKLFD KHELAECFLG LTKCDDTNVR
KEAAKCIAEI TKSEVQRKKF TKRNIIAAFL ECLRQVPTSD GSMELPIQIC RALGNICYLN
DEARDLILEL EGDAVLLRLL DITTIEDVAN AAQFIKVRGG LLSNYLLGGE GLAKRAMELG
VMKKLQGIID IGASNVEQHE DLLLNTLPLL SILTENVSDL NFDSSLNIQL SRILAASTNP
DLAEMCLELL HYQAESDEVK LILAKDGLCE TIYNLLEKYK TLASTSEARA LMKLACELIV
LILTGDDSMH YLYTTPLLKN MVDWLDSTDI DLLTTGVLAL GNFARTDSHC IYFVEQQTMN
KLLEVLAKNN GVKDDVRLQH ALLSALRNLV IPKPNKNAVI QAGLVQTILP MLEIHQPPVV
FKLLGTLRMT VDGQEKLALE LLKNKTLIEQ LVHWSKSSDY AGVTGESLRL MAWLIKHAYL
SKIAYALPRK GDAPAEQIAD KIPLTQDYDR SSLSEFLANE GTVEAMVSML TAQHLVMQNE
ALIALCILSV VYLSQPSEAA QAQLLQDELV KCEVGKKLAE LISKSSDTMT KEIVENLQNC
VNLLKSSEQL VAHLEQHNIN ELLKSIPILT EYCTL
