ID   GDT5_DICDI              Reviewed;        1176 AA.
AC   Q54MK0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Growth-differentiation transition protein 5;
DE   Flags: Precursor;
GN   Name=gdt5; ORFNames=DDB_G0285895;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   IDENTIFICATION, AND NOMENCLATURE.
RX   PubMed=15236669; DOI=10.1186/1471-213x-4-8;
RA   Chibalina M.V., Anjard C., Insall R.H.;
RT   "Gdt2 regulates the transition of Dictyostelium cells from growth to
RT   differentiation.";
RL   BMC Dev. Biol. 4:8-8(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GDT family. {ECO:0000305}.
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DR   EMBL; AAFI02000082; EAL64482.1; -; Genomic_DNA.
DR   RefSeq; XP_637990.1; XM_632898.1.
DR   AlphaFoldDB; Q54MK0; -.
DR   PaxDb; Q54MK0; -.
DR   EnsemblProtists; EAL64482; EAL64482; DDB_G0285895.
DR   GeneID; 8625341; -.
DR   KEGG; ddi:DDB_G0285895; -.
DR   dictyBase; DDB_G0285895; gdt5.
DR   HOGENOM; CLU_273574_0_0_1; -.
DR   InParanoid; Q54MK0; -.
DR   PhylomeDB; Q54MK0; -.
DR   PRO; PR:Q54MK0; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050793; P:regulation of developmental process; IBA:GO_Central.
DR   InterPro; IPR026237; STKINASEGDT.
DR   PRINTS; PR02079; STKINASEGDT.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..1176
FT                   /note="Growth-differentiation transition protein 5"
FT                   /id="PRO_0000323582"
FT   TOPO_DOM        26..913
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        914..934
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        935..1176
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          965..985
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1050..1080
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        965..983
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1063..1080
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1176 AA;  131348 MW;  D2D5E98C8224FD44 CRC64;
     MKNNFFKKTI ILLIFLSIFI LYSNADEETI TTPPGYYGLK RIKRFPHSNI ESNNISQTDA
     DLYYPDICAG ALPNAEGDLM TFYTFLDANL TLNKFLITKE SIYSFMVHSL VILPGGSVTI
     KRGLLFFSLE EYNSLNIINP AKFPLDPMGY FPGILALGGS LTLIGNYPLI YSAQVLSKTT
     LRISPPFSSI PGDNINKLYQ IKIFSDSNPL GSLCSIIMDS TRTIVNISGC PPIGNEKVMK
     VAFIKFTIDE MNTGISNRYS VKKIDESIGA SIFITGDTKV HIENFFINGD GRTLNEEYND
     HKLIFSPNNK NIVTDIIKGS NQRYRNSLYI EFSNNAVIKN CVIFEKDPRR SPIVFFASNV
     EFTSNIISSY SGSNLIAQFG TENIRSKNNH YFLVPYSRSL NTSAKSMDYG YEGGNGLYSL
     SPNIKSENDT FIGQLNIFNF NFISNRSSVT SFDRDCYAPC YNDSDSVLSS VQRPVDFYLI
     NPKYFKISNI TLFNSTIFNL FVANSNGNQP NTYTINGLVA IGPIVANLDS NFLILKDFIA
     TENFKLDGSV KRLDIINSSI ELPLTSKDII KNVSSLSTNI QNSYLYYPSN DSVEQLKDQI
     YGSVITPYYY SSPITLDRIK IVSIYPNSPL QVISGLTFNI VIQFRLIYAF QDIIICIFTS
     DNDSIQNRTV DFNVLSNKCI LPVSVGPNKE GSANVRVQIK NSLSSDYLYI IDFPQITVLK
     TYTFYSGWSM ANPDLANQQF IVNGSLFQSG CQTKTDSNCT ISENSNYVPN LPNVTSSDEL
     NSLFSSGVTS LNSNEPVIIT TAINSNSTIS QIQLFFTHVP IDQHASLLSV YIDNQPVYVL
     EPLQSNQGPT FKNITFKYEN TNSLEKINIA FTTRGDIYLT SMAIYSSNIF FIPPIIPDPT
     AIPDVPANEN TLNLLTIVLP ICSAVVVASS VMLGRLFYKK KFKKFKSADI ENEMTTIEPI
     ETSNSNIENK SESIATPQQR NEQKEIPNKI HPVLKSLVKP KIAPYTLISP LPPLETKTPE
     ALNPHFNEIG CDPINENPEI NSDEQIVLPV DTPQISPDSP QHSIPSSSPP PPPLPLPPST
     SLKPLKLPIV DSFRTSSFMF RLERSNLIEL SDPNNPLRFS SKILDFNLKG LKATLFKEYS
     NFLLISNISS STIFVKVILP RDSRTGNVGY NVHEYF