GDT6_DICDI
ID GDT6_DICDI Reviewed; 1452 AA.
AC Q55DV2;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Probable inactive serine/threonine-protein kinase gdt6;
DE AltName: Full=Growth-differentiation transition protein 6;
DE Flags: Precursor;
GN Name=gdt6; ORFNames=DDB_G0270544;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP IDENTIFICATION, AND NOMENCLATURE.
RX PubMed=15236669; DOI=10.1186/1471-213x-4-8;
RA Chibalina M.V., Anjard C., Insall R.H.;
RT "Gdt2 regulates the transition of Dictyostelium cells from growth to
RT differentiation.";
RL BMC Dev. Biol. 4:8-8(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- SIMILARITY: In the N-terminal section; belongs to the GDT family.
CC {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the protein kinase
CC superfamily. TKL Ser/Thr protein kinase family. {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72622.1; -; Genomic_DNA.
DR RefSeq; XP_646029.1; XM_640937.1.
DR AlphaFoldDB; Q55DV2; -.
DR SMR; Q55DV2; -.
DR STRING; 44689.DDB0220634; -.
DR PaxDb; Q55DV2; -.
DR EnsemblProtists; EAL72622; EAL72622; DDB_G0270544.
DR GeneID; 8616978; -.
DR KEGG; ddi:DDB_G0270544; -.
DR dictyBase; DDB_G0270544; gdt6.
DR eggNOG; KOG0192; Eukaryota.
DR HOGENOM; CLU_251247_0_0_1; -.
DR InParanoid; Q55DV2; -.
DR OMA; TADISCT; -.
DR PhylomeDB; Q55DV2; -.
DR PRO; PR:Q55DV2; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR GO; GO:0050793; P:regulation of developmental process; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR026237; STKINASEGDT.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR02079; STKINASEGDT.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..1452
FT /note="Probable inactive serine/threonine-protein kinase
FT gdt6"
FT /id="PRO_0000323583"
FT TOPO_DOM 24..972
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 973..993
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 994..1452
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 1194..1452
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 932..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1452 AA; 164887 MW; 539D827252BB89BB CRC64;
MINKISRFKI LLLFIFIISL TCAQDEELIS TPEGYYDLKR FKRFQHYKNI QPNEEAGYTD
LYYPDVCKNA IRNRDGAPTF NQRSFPGYTG VFDTLLITKG TNMTLDSTGF LTGLGIWSLL
TLCVEGNLTV LYNPDEFSFV PVHRLVILPG GTITSHANSF LFWDTYQVDE NFQEELNKRV
KIDPFNFFPG LLVLGGNLNL FGNSQLTYTA KRLNDTTLEL STPFLNMKFL WNKYIITIFT
ESIPQGDDCL FNMDSDKRTF YLIKTNYGTC NPLRETDKLM KVVISYNRYE DNYSSYISLF
SDYYGFEPNE ASIFITGDSN VYIENYLIKN LGKTKNNAYS DTKLIFSPNN TSEVIGFING
TNQRFRSSLY IEFSNNVIIK NCVIIESSSE TRSPLVFFGS NVYLSDNLIS SKSGSSLIAQ
YGTENIQSIN NFYFQKGVSH QTASQILNPI NMDFGNEGNG IYSVSPNLLS SDDFFIGQNY
SITFNFIANR SKITGFDQDC YAPCFSDSIN FSNKIQYPVD FKIFNPKFLP TNNTNSDWYI
LNINDNGNQP GTYYTVKNLT TLDPVQFSLD NSALSFLGLE ASENFKMNGN AKRLDIVNSI
ISSKALTNQQ QIISKVSSSA ISFKNSYIYS KLGQQITPID NQIYGSLITP FYYNDSDILN
QVKILSIFPN VPFQIVSGSI LNVSINLQII STADISCTFS SDNSTFSTTI LVNPSDGSCV
LPLVFEKEGY FNLKVTLKIS TSKDYYYIVD FPKITVYNEY LFYSGWVMID SSTDEFLFEG
KIFKSGCQQQ VLGNCTISTN SKFINGLPNV TETDELNRLF SSGITSINPY EPVTITIPID
KESKKNQIQL FFTHQPIDIE YSLLSIYVEN QPIFLLEQLQ SGLGSTFKNL TFNYENSKSL
EIINISFTTR GDIYLTSMAV YSSAIPIIVT PTPTSTTSTP TPTSTTTSTP IPTTTPTTTP
KTSKTTSKNK LKIALPICLF ALLVAVGVLI CFIFRKKKQK KQKLDNNMED GSEMSSIKIK
KENYNSFNKF KESTVFKNDD FKNYSNPTET TIYSTSDSLL NFVGSDFLNY SDPNIPLSFS
KNILEFGLKG SKCDINTFLS DSLRITNNSN IILCICTVLP RNDSGEVNVS PDSFELDPNQ
SREIEFSLKL NCTTRFFERF AIEARHTHSF KSIHTHLFIH VESKISSKLD IKEIEVKELI
SQNNLSTVNI ANYRGLQVVL RKIKTHSANY TKTYSQAIKK FYTEMDILSK LKNKNIVSFI
GCTHDSSHLW IVTEYAPLGS LSSLIHQKKE KLSLIQKVKL MLDTAKGCEF LHSNDITNCN
IKSNNLLLFS TMEKDDVCVK ISDFGIKKFE VQNQNEKEIF KDEKDQKLID VYEFGITFYE
TMLEETPENL SNLILEGERP TLDLEKLDAD IRNIIERCWN QNKRSTFSEI SISLKEKYTK
LLEKNNELIQ EN
