GDU6_ARATH
ID GDU6_ARATH Reviewed; 111 AA.
AC Q3EAV6;
DT 31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Protein GLUTAMINE DUMPER 6;
GN Name=GDU6; OrderedLocusNames=At3g30725; ORFNames=T4A2.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=15208395; DOI=10.1105/tpc.021642;
RA Pilot G., Stransky H., Bushey D.F., Pratelli R., Ludewig U., Wingate V.P.,
RA Frommer W.B.;
RT "Overexpression of GLUTAMINE DUMPER1 leads to hypersecretion of glutamine
RT from hydathodes of Arabidopsis leaves.";
RL Plant Cell 16:1827-1840(2004).
RN [4]
RP GENE FAMILY.
RX PubMed=17157837; DOI=10.1016/j.febslet.2006.11.064;
RA Pratelli R., Pilot G.;
RT "The plant-specific VIMAG domain of Glutamine Dumper1 is necessary for the
RT function of the protein in Arabidopsis.";
RL FEBS Lett. 580:6961-6966(2006).
RN [5]
RP ERRATUM OF PUBMED:17157837.
RX DOI=10.1016/j.febslet.2007.02.027;
RA Pratelli R., Pilot G.;
RL FEBS Lett. 581:1248-1249(2007).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RA Pratelli R., Frommer W.B., Pilot G.;
RT "The over-expression of GDU-like genes leads to modification in amino acid
RT content and transport.";
RL (In) Proceedings of the 19th international conference on Arabidopsis
RL research, pp.abstract#10018, Montreal (2008).
RN [7]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=20018597; DOI=10.1104/pp.109.151746;
RA Pratelli R., Voll L.M., Horst R.J., Frommer W.B., Pilot G.;
RT "Stimulation of nonselective amino acid export by glutamine dumper
RT proteins.";
RL Plant Physiol. 152:762-773(2010).
CC -!- FUNCTION: Probable subunit of an amino acid transporter involved in the
CC regulation of the amino acid metabolism. Stimulates amino acid export
CC by activating nonselective amino acid facilitators.
CC {ECO:0000269|PubMed:20018597, ECO:0000269|Ref.6}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|Ref.6}; Single-pass
CC membrane protein {ECO:0000269|Ref.6}.
CC -!- TISSUE SPECIFICITY: Expressed in the vascular tissues.
CC {ECO:0000269|PubMed:20018597, ECO:0000269|Ref.6}.
CC -!- DOMAIN: The VIMAG motif is necessary for the function of the protein.
CC {ECO:0000250}.
CC -!- MISCELLANEOUS: Overexpression of GLUTAMINE DUMPER 6 leads to free amino
CC acid levels accumulation and plant size decrease (Ref.6,
CC PubMed:20018597).
CC -!- SIMILARITY: Belongs to the GLUTAMINE DUMPER 1 (TC 9.B.60) family.
CC {ECO:0000305}.
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DR EMBL; AP002066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002686; AEE77654.1; -; Genomic_DNA.
DR RefSeq; NP_850650.1; NM_180319.2.
DR AlphaFoldDB; Q3EAV6; -.
DR SMR; Q3EAV6; -.
DR BioGRID; 8135; 2.
DR IntAct; Q3EAV6; 4.
DR MINT; Q3EAV6; -.
DR STRING; 3702.AT3G30725.1; -.
DR PaxDb; Q3EAV6; -.
DR EnsemblPlants; AT3G30725.1; AT3G30725.1; AT3G30725.
DR GeneID; 822809; -.
DR Gramene; AT3G30725.1; AT3G30725.1; AT3G30725.
DR KEGG; ath:AT3G30725; -.
DR Araport; AT3G30725; -.
DR TAIR; locus:1005716497; AT3G30725.
DR eggNOG; ENOG502S94S; Eukaryota.
DR HOGENOM; CLU_112624_3_0_1; -.
DR InParanoid; Q3EAV6; -.
DR OMA; PTYMAKP; -.
DR OrthoDB; 1624437at2759; -.
DR PhylomeDB; Q3EAV6; -.
DR PRO; PR:Q3EAV6; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q3EAV6; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR GO; GO:0080143; P:regulation of amino acid export; IMP:TAIR.
DR InterPro; IPR040359; GDU.
DR PANTHER; PTHR33228; PTHR33228; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..111
FT /note="Protein GLUTAMINE DUMPER 6"
FT /id="PRO_0000419944"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..111
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 40..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 75..79
FT /note="VIMAG; degenerate"
FT COMPBIAS 48..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 111 AA; 12127 MW; 26C94317CC0A0ABA CRC64;
MRPTPKVEIW KSPVPYLFGG LFLLVLLIAL ALLSLVCTHQ KPSSSSNNNH MDEEDDVGDK
DAKPITREYL PKIVVILAGD NKPTCLAVPV VVPPPTSIFR CNCDNVTVIS T
