GDU7_ARATH
ID GDU7_ARATH Reviewed; 97 AA.
AC Q3E8L0; A0MFK2;
DT 31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Protein GLUTAMINE DUMPER 7;
GN Name=GDU7; OrderedLocusNames=At5g38770; ORFNames=MKD10.70;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP GENE FAMILY.
RX PubMed=17157837; DOI=10.1016/j.febslet.2006.11.064;
RA Pratelli R., Pilot G.;
RT "The plant-specific VIMAG domain of Glutamine Dumper1 is necessary for the
RT function of the protein in Arabidopsis.";
RL FEBS Lett. 580:6961-6966(2006).
RN [5]
RP ERRATUM OF PUBMED:17157837.
RX DOI=10.1016/j.febslet.2007.02.027;
RA Pratelli R., Pilot G.;
RL FEBS Lett. 581:1248-1249(2007).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RA Pratelli R., Frommer W.B., Pilot G.;
RT "The over-expression of GDU-like genes leads to modification in amino acid
RT content and transport.";
RL (In) Proceedings of the 19th international conference on Arabidopsis
RL research, pp.abstract#10018, Montreal (2008).
RN [7]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=20018597; DOI=10.1104/pp.109.151746;
RA Pratelli R., Voll L.M., Horst R.J., Frommer W.B., Pilot G.;
RT "Stimulation of nonselective amino acid export by glutamine dumper
RT proteins.";
RL Plant Physiol. 152:762-773(2010).
CC -!- FUNCTION: Probable subunit of an amino acid transporter involved in the
CC regulation of the amino acid metabolism. Stimulates amino acid export
CC by activating nonselective amino acid facilitators.
CC {ECO:0000269|PubMed:20018597, ECO:0000269|Ref.6}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|Ref.6}; Single-pass
CC membrane protein {ECO:0000269|Ref.6}.
CC -!- TISSUE SPECIFICITY: Expressed in the vascular tissues, even in the
CC minor veins of the leaves. {ECO:0000269|PubMed:20018597,
CC ECO:0000269|Ref.6}.
CC -!- DOMAIN: The VIMAG motif is necessary for the function of the protein.
CC {ECO:0000250}.
CC -!- MISCELLANEOUS: Overexpression of GLUTAMINE DUMPER 7 leads to free amino
CC acid levels accumulation (Ref.6, PubMed:20018597).
CC -!- SIMILARITY: Belongs to the GLUTAMINE DUMPER 1 (TC 9.B.60) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK28285.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB011478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED94358.1; -; Genomic_DNA.
DR EMBL; DQ447014; ABE65568.1; -; Genomic_DNA.
DR EMBL; DQ653328; ABK28285.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; NP_198693.1; NM_123238.2.
DR AlphaFoldDB; Q3E8L0; -.
DR BioGRID; 19119; 2.
DR IntAct; Q3E8L0; 3.
DR MINT; Q3E8L0; -.
DR PaxDb; Q3E8L0; -.
DR PRIDE; Q3E8L0; -.
DR EnsemblPlants; AT5G38770.1; AT5G38770.1; AT5G38770.
DR GeneID; 833868; -.
DR Gramene; AT5G38770.1; AT5G38770.1; AT5G38770.
DR KEGG; ath:AT5G38770; -.
DR Araport; AT5G38770; -.
DR TAIR; locus:2166635; AT5G38770.
DR HOGENOM; CLU_112624_3_0_1; -.
DR OMA; MAYACYH; -.
DR OrthoDB; 1624437at2759; -.
DR PhylomeDB; Q3E8L0; -.
DR PRO; PR:Q3E8L0; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q3E8L0; baseline and differential.
DR Genevisible; Q3E8L0; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR GO; GO:0080143; P:regulation of amino acid export; IMP:TAIR.
DR InterPro; IPR040359; GDU.
DR PANTHER; PTHR33228; PTHR33228; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..97
FT /note="Protein GLUTAMINE DUMPER 7"
FT /id="PRO_0000419945"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOTIF 78..82
FT /note="VIMAG"
SQ SEQUENCE 97 AA; 10819 MW; F9BC331DF150103B CRC64;
MSLHRDSMVP VNSRLENMDS PILSKICAWG VMLGLFALSL FAMAYACYHK QTSNSCIEEK
QGKKQVLKPL DMEPKIVVIM AGNENPTFFA KPTQINA
