GDX_CITFR
ID GDX_CITFR Reviewed; 105 AA.
AC O69279;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Guanidinium exporter {ECO:0000250|UniProtKB:P69937};
GN Name=gdx {ECO:0000250|UniProtKB:P69937}; Synonyms=sugE;
OS Citrobacter freundii.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Citrobacter; Citrobacter freundii complex.
OX NCBI_TaxID=546;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=OS60;
RX PubMed=9677290; DOI=10.1006/jmbi.1998.1894;
RA Bishop R.E., Leskiw B.K., Hodges R.S., Kay C.M., Weiner J.H.;
RT "The entericidin locus of Escherichia coli and its implications for
RT programmed bacterial cell death.";
RL J. Mol. Biol. 280:583-596(1998).
RN [2]
RP TOPOLOGY, AND SUBCELLULAR LOCATION.
RX PubMed=14651958; DOI=10.1016/j.bbrc.2003.11.018;
RA Son M.S., Del Castilho C., Duncalf K.A., Carney D., Weiner J.H.,
RA Turner R.J.;
RT "Mutagenesis of SugE, a small multidrug resistance protein.";
RL Biochem. Biophys. Res. Commun. 312:914-921(2003).
CC -!- FUNCTION: Guanidinium ion exporter. Couples guanidinium export to the
CC proton motive force, exchanging one guanidinium ion for two protons.
CC {ECO:0000250|UniProtKB:P69937}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:14651958}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:14651958}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC Gdx/SugE subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U21727; AAC46457.1; -; Genomic_DNA.
DR RefSeq; WP_000118520.1; NZ_VTEC01000079.1.
DR AlphaFoldDB; O69279; -.
DR SMR; O69279; -.
DR STRING; 1333848.CFNIH1_08405; -.
DR GeneID; 61125662; -.
DR OrthoDB; 1990300at2; -.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR PANTHER; PTHR30561; PTHR30561; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..105
FT /note="Guanidinium exporter"
FT /id="PRO_0000108094"
FT TOPO_DOM 1
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:14651958"
FT TRANSMEM 2..19
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 20..28
FT /note="Periplasmic"
FT /evidence="ECO:0000305|PubMed:14651958"
FT TRANSMEM 29..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:14651958"
FT TRANSMEM 55..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..86
FT /note="Periplasmic"
FT /evidence="ECO:0000305|PubMed:14651958"
FT TRANSMEM 87..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:14651958"
SQ SEQUENCE 105 AA; 10897 MW; 62DA129ADA86E765 CRC64;
MSWIVLLIAG LLEVVWAIGL KYTHGFTRLT PSIITIAAMI VSIAMLSWAM RTLPVGTAYA
VWTGIGAVGA AITGILLLGE SASPARLLSL GLIVAGIIGL KLSTH
