ID   GDX_ECOL6               Reviewed;         105 AA.
AC   Q8FAL8;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Guanidinium exporter {ECO:0000250|UniProtKB:P69937};
GN   Name=gdx {ECO:0000250|UniProtKB:P69937}; Synonyms=sugE;
GN   OrderedLocusNames=c5236;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Guanidinium ion exporter. Couples guanidinium export to the
CC       proton motive force, exchanging one guanidinium ion for two protons.
CC       {ECO:0000250|UniProtKB:P69937}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P69937}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P69937}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC       Gdx/SugE subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN83658.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN83658.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000118477.1; NC_004431.1.
DR   AlphaFoldDB; Q8FAL8; -.
DR   SMR; Q8FAL8; -.
DR   STRING; 199310.c5236; -.
DR   EnsemblBacteria; AAN83658; AAN83658; c5236.
DR   KEGG; ecc:c5236; -.
DR   eggNOG; COG2076; Bacteria.
DR   HOGENOM; CLU_133067_1_1_6; -.
DR   OMA; FEIAWAI; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   PANTHER; PTHR30561; PTHR30561; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..105
FT                   /note="Guanidinium exporter"
FT                   /id="PRO_0000108097"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        22..28
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..81
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..105
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   105 AA;  10882 MW;  C469DC2EDC1B7C09 CRC64;
     MSWIILVIAG LLEVVWAVGL KYTHGFSRLT PSVITVTAMI VSLALLAWAM KSLPVGTAYA
     VWTGIGAVGA AITGIVLLGE SANPMRLASL ALIVLGIIGL KLSTH