GDX_PHOLL
ID GDX_PHOLL Reviewed; 104 AA.
AC Q7MZY0;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Guanidinium exporter {ECO:0000250|UniProtKB:P69937};
GN Name=gdx {ECO:0000250|UniProtKB:P69937}; Synonyms=sugE;
GN OrderedLocusNames=plu4129;
OS Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS TT01).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Photorhabdus.
OX NCBI_TaxID=243265;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15139 / CIP 105565 / TT01;
RX PubMed=14528314; DOI=10.1038/nbt886;
RA Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA Glaser P., Boemare N., Danchin A., Kunst F.;
RT "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT luminescens.";
RL Nat. Biotechnol. 21:1307-1313(2003).
CC -!- FUNCTION: Guanidinium ion exporter. Couples guanidinium export to the
CC proton motive force, exchanging one guanidinium ion for two protons.
CC {ECO:0000250|UniProtKB:P69937}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P69937}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P69937}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC Gdx/SugE subfamily. {ECO:0000305}.
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DR EMBL; BX571872; CAE16501.1; -; Genomic_DNA.
DR RefSeq; WP_011148245.1; NC_005126.1.
DR AlphaFoldDB; Q7MZY0; -.
DR SMR; Q7MZY0; -.
DR STRING; 243265.plu4129; -.
DR EnsemblBacteria; CAE16501; CAE16501; plu4129.
DR GeneID; 24169417; -.
DR KEGG; plu:plu4129; -.
DR eggNOG; COG2076; Bacteria.
DR HOGENOM; CLU_133067_1_2_6; -.
DR OMA; FEIAWAI; -.
DR OrthoDB; 1990300at2; -.
DR BioCyc; PLUM243265:PLU_RS20425-MON; -.
DR Proteomes; UP000002514; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR PANTHER; PTHR30561; PTHR30561; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..104
FT /note="Guanidinium exporter"
FT /id="PRO_0000108100"
FT TOPO_DOM 1
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 2..19
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 20..28
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..81
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 104 AA; 10809 MW; F42A21B9C9314F48 CRC64;
MSWFVLVIAG LFEVVWAVGL KYTHGFTRLI PSLITASAVA LSMGLLAYAM KGLPIGTAYA
VWTGIGAVGT AIFGIIVFGE SASFARILSF ALIIAGIIGL KLSS
