ID   GDX_PROVU               Reviewed;         104 AA.
AC   P20928;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Guanidinium exporter {ECO:0000250|UniProtKB:P69937};
GN   Name=gdx {ECO:0000250|UniProtKB:P69937}; Synonyms=sugE;
OS   Proteus vulgaris.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=585;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3308458; DOI=10.1111/j.1432-1033.1987.tb13362.x;
RA   Cole S.T.;
RT   "Nucleotide sequence and comparative analysis of the frd operon encoding
RT   the fumarate reductase of Proteus vulgaris. Extensive sequence divergence
RT   of the membrane anchors and absence of an frd-linked ampC cephalosporinase
RT   gene.";
RL   Eur. J. Biochem. 167:481-488(1987).
CC   -!- FUNCTION: Guanidinium ion exporter. Couples guanidinium export to the
CC       proton motive force, exchanging one guanidinium ion for two protons.
CC       {ECO:0000250|UniProtKB:P69937}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P69937}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P69937}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC       Gdx/SugE subfamily. {ECO:0000305}.
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DR   EMBL; X06151; CAA29512.1; -; Genomic_DNA.
DR   PIR; S00120; S00120.
DR   AlphaFoldDB; P20928; -.
DR   SMR; P20928; -.
DR   STRING; 585.DR95_2062; -.
DR   eggNOG; COG2076; Bacteria.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   PANTHER; PTHR30561; PTHR30561; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..104
FT                   /note="Guanidinium exporter"
FT                   /id="PRO_0000108101"
FT   TOPO_DOM        1..3
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        4..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        27..32
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        51..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..83
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        104
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   104 AA;  11014 MW;  1A1F4AC9C7A94955 CRC64;
     MSWIILFVAG LLEIVWAVGL KYTHGFTRLT PSIITISAMI VSMGMLSYAM KGLPAGTAYA
     IWTGIGAVGT AIFGIIVFGE SANIYRLLSL AMIVFGIIGL KLAS