ID   GDX_SALCH               Reviewed;         105 AA.
AC   Q79K00; Q5J3Z0;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Guanidinium exporter {ECO:0000250|UniProtKB:P69937};
GN   Name=gdx {ECO:0000250|UniProtKB:P69937}; Synonyms=sugE;
GN   OrderedLocusNames=SCH_092;
OS   Salmonella choleraesuis (strain SC-B67).
OG   Plasmid pSCR1, and Plasmid pSC138.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=321314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SC-B67; PLASMID=pSCR1;
RA   Chiu C.-H., Chu C.;
RT   "AmpC resistant Salmonella enterica Choleraesuis.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC-B67; PLASMID=pSC138;
RX   PubMed=15781495; DOI=10.1093/nar/gki297;
RA   Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S.,
RA   Lee Y.-S.;
RT   "The genome sequence of Salmonella enterica serovar Choleraesuis, a highly
RT   invasive and resistant zoonotic pathogen.";
RL   Nucleic Acids Res. 33:1690-1698(2005).
CC   -!- FUNCTION: Guanidinium ion exporter. Couples guanidinium export to the
CC       proton motive force, exchanging one guanidinium ion for two protons.
CC       {ECO:0000250|UniProtKB:P69937}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P69937}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P69937}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC       Gdx/SugE subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAS76375.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY253913; AAP92686.1; -; Genomic_DNA.
DR   EMBL; AY509004; AAS76375.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000118520.1; NC_006856.1.
DR   AlphaFoldDB; Q79K00; -.
DR   SMR; Q79K00; -.
DR   EnsemblBacteria; AAS76375; AAS76375; SCH_092.
DR   GeneID; 61125662; -.
DR   KEGG; sec:SCH_092; -.
DR   HOGENOM; CLU_133067_1_1_6; -.
DR   Proteomes; UP000000538; Plasmid pSC138.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   PANTHER; PTHR30561; PTHR30561; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Plasmid;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..105
FT                   /note="Guanidinium exporter"
FT                   /id="PRO_0000108102"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        22..28
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..81
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..105
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   105 AA;  10897 MW;  62DA129ADA86E765 CRC64;
     MSWIVLLIAG LLEVVWAIGL KYTHGFTRLT PSIITIAAMI VSIAMLSWAM RTLPVGTAYA
     VWTGIGAVGA AITGILLLGE SASPARLLSL GLIVAGIIGL KLSTH