GDX_SALTY
ID GDX_SALTY Reviewed; 105 AA.
AC Q7CP98;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Guanidinium exporter {ECO:0000250|UniProtKB:P69937};
GN Name=gdx {ECO:0000250|UniProtKB:P69937}; Synonyms=sugE;
GN OrderedLocusNames=STM4338;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Guanidinium ion exporter. Couples guanidinium export to the
CC proton motive force, exchanging one guanidinium ion for two protons.
CC {ECO:0000250|UniProtKB:P69937}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P69937}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P69937}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC Gdx/SugE subfamily. {ECO:0000305}.
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DR EMBL; AE006468; AAL23161.1; -; Genomic_DNA.
DR RefSeq; NP_463202.1; NC_003197.2.
DR RefSeq; WP_000118469.1; NC_003197.2.
DR AlphaFoldDB; Q7CP98; -.
DR SMR; Q7CP98; -.
DR STRING; 99287.STM4338; -.
DR PaxDb; Q7CP98; -.
DR EnsemblBacteria; AAL23161; AAL23161; STM4338.
DR GeneID; 1255864; -.
DR KEGG; stm:STM4338; -.
DR PATRIC; fig|99287.12.peg.4565; -.
DR HOGENOM; CLU_133067_1_2_6; -.
DR OMA; FEIAWAI; -.
DR PhylomeDB; Q7CP98; -.
DR BioCyc; SENT99287:STM4338-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR PANTHER; PTHR30561; PTHR30561; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..105
FT /note="Guanidinium exporter"
FT /id="PRO_0000108105"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 22..28
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..81
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..105
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 105 AA; 10869 MW; 1D396AF413953701 CRC64;
MSWIILLIAG LLEVVWAVGL KYTHGFSRLT PSIITITAMV ISMALLSWAM KTLPVGTAYA
IWTGIGAVGA AITGILLLGE SASPARLLSL GLIVAGIIGL KLSAH
