GDX_YERPE
ID GDX_YERPE Reviewed; 104 AA.
AC Q8D1E4; Q0WJV5; Q74XC5; Q8ZIX9;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Guanidinium exporter {ECO:0000250|UniProtKB:P69937};
GN Name=gdx {ECO:0000250|UniProtKB:P69937}; Synonyms=sugE;
GN OrderedLocusNames=YPO0355, y0613, YP_0511;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Guanidinium ion exporter. Couples guanidinium export to the
CC proton motive force, exchanging one guanidinium ion for two protons.
CC {ECO:0000250|UniProtKB:P69937}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P69937}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P69937}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC Gdx/SugE subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM84201.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAS60781.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL590842; CAL19037.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84201.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS60781.1; ALT_INIT; Genomic_DNA.
DR PIR; AC0044; AC0044.
DR RefSeq; WP_002228124.1; NZ_WUCM01000014.1.
DR RefSeq; YP_002345433.1; NC_003143.1.
DR AlphaFoldDB; Q8D1E4; -.
DR SMR; Q8D1E4; -.
DR STRING; 214092.YPO0355; -.
DR PaxDb; Q8D1E4; -.
DR DNASU; 1145560; -.
DR EnsemblBacteria; AAM84201; AAM84201; y0613.
DR EnsemblBacteria; AAS60781; AAS60781; YP_0511.
DR GeneID; 66843177; -.
DR KEGG; ype:YPO0355; -.
DR KEGG; ypk:y0613; -.
DR KEGG; ypm:YP_0511; -.
DR PATRIC; fig|214092.21.peg.591; -.
DR eggNOG; COG2076; Bacteria.
DR HOGENOM; CLU_133067_1_2_6; -.
DR OMA; FEIAWAI; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR PANTHER; PTHR30561; PTHR30561; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..104
FT /note="Guanidinium exporter"
FT /id="PRO_0000108108"
FT TOPO_DOM 1
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 2..19
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 20..28
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..81
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 104 AA; 10651 MW; 6DADB41E0B97B5BB CRC64;
MAWIILVIAG LLEVIWAIGL KYSHGFSRLT PSIITLVAMA ASVFLLAYAM KSLPAGTAYA
VWTGIGAVGT AILGIVLLGE SASLARILSL GLILAGIIGL KLAS
