ID   GD_BHV1P                Reviewed;         417 AA.
AC   P0CK29; P24906;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   02-JUN-2021, entry version 26.
DE   RecName: Full=Envelope glycoprotein D;
DE            Short=gD;
DE   AltName: Full=Glycoprotein IV;
DE   Flags: Precursor;
GN   Name=gD; Synonyms=gIV, US6;
OS   Bovine herpesvirus 1.1 (strain P8-2) (BoHV-1) (Infectious bovine
OS   rhinotracheitis virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10324;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 19-48.
RX   PubMed=2168991; DOI=10.1128/jvi.64.10.5132-5142.1990;
RA   Tikoo S.K., Fitzpatrick D.R., Babiuk L.A., Zamb T.J.;
RT   "Molecular cloning, sequencing, and expression of functional bovine
RT   herpesvirus 1 glycoprotein gIV in transfected bovine cells.";
RL   J. Virol. 64:5132-5142(1990).
CC   -!- FUNCTION: Envelope glycoprotein that binds to host cell entry
CC       receptors. May trigger fusion with host membrane, by recruiting the
CC       fusion machinery composed of gB and gH/gL (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}. Note=During virion morphogenesis, this
CC       protein probably accumulates in the endosomes and trans-Golgi where
CC       secondary envelopment occurs. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae glycoprotein D family.
CC       {ECO:0000305}.
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DR   EMBL; M59846; AAA46050.1; -; Genomic_DNA.
DR   PIR; A36548; VGBEIB.
DR   RefSeq; NP_045370.1; NC_001847.1.
DR   SMR; P0CK29; -.
DR   GeneID; 1487406; -.
DR   KEGG; vg:1487406; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0098670; P:entry receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR002896; Herpes_glycop_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   Pfam; PF01537; Herpes_glycop_D; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Host-virus interaction; Membrane; Signal; Transmembrane;
KW   Transmembrane helix; Viral attachment to host cell;
KW   Viral attachment to host entry receptor; Viral envelope protein; Virion;
KW   Virus entry into host cell.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000269|PubMed:2168991"
FT   CHAIN           19..417
FT                   /note="Envelope glycoprotein D"
FT                   /id="PRO_0000038219"
FT   TOPO_DOM        19..360
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        390..417
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   REGION          259..356
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        102
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        75..197
FT                   /evidence="ECO:0000250"
FT   DISULFID        114..213
FT                   /evidence="ECO:0000250"
FT   DISULFID        126..135
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   417 AA;  44925 MW;  4DFBE3ACF93DF545 CRC64;
     MQGPTLAVLG ALLAVAVSLP TPAPRVTVYV DPPAYPMPRY NYTERWHTTG PIPSPFADGR
     EQPVEVRYAT SAAACDMLAL IADPQVGRTL WEAVRRHARA YNATVIWYKI ESGCARPLYY
     MEYTECEPRK HFGYCRYRTP PFWDSFLAGF AYPTDDELGL IMAAPARLVE GQYRRALYID
     GTVAYTDFMV SLPAGDCWFS KLGAARGYTF GACFPARDYE QKKVLRLTYL TQYYPQEAHK
     AIVDYWFMRH GGVVPPYFEE SKGYEPPPAA DGGSPAPPGD DEAREDEGET EDGAAGREGN
     GGPPGPEGDG ESQTPEANGG AEGEPKPGPS PDADRPEGWP SLEAITHPPP APATPAAPDA
     VPVSVGIGIA AAAIACVAAA AAGAYFVYTR RRGAGPLPRK PKKLPAFGNV NYSALPG