ID   GD_PSHV1                Reviewed;         383 AA.
AC   Q6UDF6;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   02-JUN-2021, entry version 52.
DE   RecName: Full=Envelope glycoprotein D;
DE            Short=gD;
DE   Flags: Precursor;
GN   Name=US6;
OS   Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1)
OS   (Pacheco's disease virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Iltovirus.
OX   NCBI_TaxID=670426;
OH   NCBI_TaxID=152276; Amazona oratrix (yellow-headed parrot).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=97-0001;
RX   PubMed=16873243; DOI=10.1128/jvi.00134-06;
RA   Thureen D.R., Keeler C.L. Jr.;
RT   "Psittacid herpesvirus 1 and infectious laryngotracheitis virus:
RT   Comparative genome sequence analysis of two avian alphaherpesviruses.";
RL   J. Virol. 80:7863-7872(2006).
CC   -!- FUNCTION: Envelope glycoprotein that binds to host cell entry
CC       receptors. May trigger fusion with host membrane, by recruiting the
CC       fusion machinery composed of gB and gH/gL (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}. Note=During virion morphogenesis, this
CC       protein probably accumulates in the endosomes and trans-Golgi where
CC       secondary envelopment occurs. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae glycoprotein D family.
CC       {ECO:0000305}.
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DR   EMBL; AY372243; AAQ73754.1; -; Genomic_DNA.
DR   RefSeq; NP_944448.1; NC_005264.1.
DR   SMR; Q6UDF6; -.
DR   GeneID; 2656976; -.
DR   KEGG; vg:2656976; -.
DR   Proteomes; UP000006840; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0098670; P:entry receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR002896; Herpes_glycop_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   Pfam; PF01537; Herpes_glycop_D; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Host-virus interaction; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW   Viral attachment to host cell; Viral attachment to host entry receptor;
KW   Viral envelope protein; Virion; Virus entry into host cell.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..383
FT                   /note="Envelope glycoprotein D"
FT                   /id="PRO_0000406853"
FT   TOPO_DOM        31..358
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        359..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        380..383
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   REGION          315..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        76..197
FT                   /evidence="ECO:0000250|UniProtKB:P57083"
FT   DISULFID        115..212
FT                   /evidence="ECO:0000250|UniProtKB:P57083"
FT   DISULFID        127..136
FT                   /evidence="ECO:0000250|UniProtKB:P57083"
SQ   SEQUENCE   383 AA;  42036 MW;  763436B76EC3273B CRC64;
     MPAATMATPG YLACRTSVAT LLFFVLLRRA AILGAGGAPS PARIVDYLIG YTRVGDMDKL
     YSQYADRYLD VTLHGCERAV VDPLGDMRHV LASEGASGQE FTASVIWYYV FPDVCFAPVF
     RREYLRCIRP RKLEDCYTTS PFMWTREFYV DAFLAGSGTG IELLGLNKKL TGTYMLVVRV
     GTTTRTALVT VNVVGECPTT MEEVTTTLRG NCWRGRQYTT DFNGDGMYLF DTEEEHRRIV
     YKAYQDKLKV ASPNATDAPI SYPRAYTGAD ERLAPYTLQP VSTDDHYLPG CPWGIGCDLD
     QTSASGVIEI EDHDESDVRL VSYPPPTLPS PGPGGNENGA GYSDNRPDPK VVGPTVGPGA
     IILVVMCAPI LIGLTAFTIR KYC