ID   GEDD_ASPTN              Reviewed;         389 AA.
AC   Q0CCY2;
DT   07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Geodin cluster transcriptional coactivator gedD {ECO:0000303|PubMed:24009710};
DE   AltName: Full=Geodin synthesis protein D {ECO:0000303|PubMed:24009710};
GN   Name=gedD; ORFNames=ATEG_08452;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=12536215; DOI=10.1038/nbt781;
RA   Askenazi M., Driggers E.M., Holtzman D.A., Norman T.C., Iverson S.,
RA   Zimmer D.P., Boers M.E., Blomquist P.R., Martinez E.J., Monreal A.W.,
RA   Feibelman T.P., Mayorga M.E., Maxon M.E., Sykes K., Tobin J.V., Cordero E.,
RA   Salama S.R., Trueheart J., Royer J.C., Madden K.T.;
RT   "Integrating transcriptional and metabolite profiles to direct the
RT   engineering of lovastatin-producing fungal strains.";
RL   Nat. Biotechnol. 21:150-156(2003).
RN   [3]
RP   FUNCTION.
RX   PubMed=24009710; DOI=10.1371/journal.pone.0072871;
RA   Nielsen M.T., Nielsen J.B., Anyaogu D.C., Holm D.K., Nielsen K.F.,
RA   Larsen T.O., Mortensen U.H.;
RT   "Heterologous reconstitution of the intact geodin gene cluster in
RT   Aspergillus nidulans through a simple and versatile PCR based approach.";
RL   PLoS ONE 8:E72871-E72871(2013).
CC   -!- FUNCTION: Transcriptional coactivator; part of the gene cluster that
CC       mediates the biosynthesis of geodin, an intermediate in the
CC       biosynthesis of other natural products (PubMed:12536215,
CC       PubMed:24009710). With gedR, coregulates the production of geodin (By
CC       similarity). {ECO:0000250|UniProtKB:Q4WQZ4,
CC       ECO:0000269|PubMed:12536215, ECO:0000269|PubMed:24009710}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; CH476605; EAU31625.1; -; Genomic_DNA.
DR   RefSeq; XP_001217073.1; XM_001217073.1.
DR   AlphaFoldDB; Q0CCY2; -.
DR   SMR; Q0CCY2; -.
DR   EnsemblFungi; EAU31625; EAU31625; ATEG_08452.
DR   GeneID; 4353102; -.
DR   VEuPathDB; FungiDB:ATEG_08452; -.
DR   eggNOG; KOG3178; Eukaryota.
DR   HOGENOM; CLU_005533_11_0_1; -.
DR   OMA; QLNWAKI; -.
DR   OrthoDB; 817726at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..389
FT                   /note="Geodin cluster transcriptional coactivator gedD"
FT                   /id="PRO_5004170008"
FT   DOMAIN          13..83
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   DNA_BIND        43..62
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
SQ   SEQUENCE   389 AA;  42334 MW;  646074F95404D122 CRC64;
     MLLCDSLSFF QQLAWHVQLL ACLQWLGRSQ VLICLPLGSS FSVRDLAQLC GVSETTLSRV
     VRLTATAGFL QEPQPGQIMH TPLSGAFGGQ PSLRDATLFL SNRITPSALQ MASTLHLGRT
     ESAAESAYNL AFATSRTFRD ACRVTPKLHR QWIAYLRNTG DSDDSITEVL TRLDWAHLGR
     SCIVESGARS TTRARVLSKL YPALRFVVQL SGPDQDAHDT RASLTPVPSI PGIIQLDENY
     PHISVQTRNL GLAQPVLDAA VYILHLPSLS VANSPSRSIV VKELQAHMDV LSSNPSAVLI
     ATARVLPPPG SVHREVEAMC RVRDFTLMQL TNEHEPEVAD FDDLVNAVEA GGAGRLVVAD
     KLRARNNLLV AFVLKYQEVS APGALPSSF