ID   GEDR_ASPTN              Reviewed;         229 AA.
AC   Q0CCY1;
DT   07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Geodin cluster transcription factor {ECO:0000303|PubMed:24009710};
DE   AltName: Full=Geodin synthesis protein R {ECO:0000303|PubMed:24009710};
GN   Name=gedR {ECO:0000303|PubMed:24009710}; ORFNames=ATEG_08453;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=24009710; DOI=10.1371/journal.pone.0072871;
RA   Nielsen M.T., Nielsen J.B., Anyaogu D.C., Holm D.K., Nielsen K.F.,
RA   Larsen T.O., Mortensen U.H.;
RT   "Heterologous reconstitution of the intact geodin gene cluster in
RT   Aspergillus nidulans through a simple and versatile PCR based approach.";
RL   PLoS ONE 8:E72871-E72871(2013).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of geodin, an intermediate
CC       in the biosynthesis of other natural products (PubMed:24009710).
CC       {ECO:0000269|PubMed:24009710}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; CH476605; EAU31626.1; -; Genomic_DNA.
DR   RefSeq; XP_001217075.1; XM_001217075.1.
DR   AlphaFoldDB; Q0CCY1; -.
DR   SMR; Q0CCY1; -.
DR   EnsemblFungi; EAU31626; EAU31626; ATEG_08453.
DR   GeneID; 4353103; -.
DR   VEuPathDB; FungiDB:ATEG_08453; -.
DR   HOGENOM; CLU_1209591_0_0_1; -.
DR   OrthoDB; 1396569at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..229
FT                   /note="Geodin cluster transcription factor"
FT                   /id="PRO_0000437057"
FT   DNA_BIND        12..39
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          50..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          141..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..167
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   229 AA;  24528 MW;  AC377911396E5B4C CRC64;
     MSAEGHKLRG SCHACAASKV RCSKEKPTCS RCSKRGTTCE YLITKRPGRK QLNNRSTAKE
     SSNTTRTSLA TVPQGLLEPD PMSTAIPLAD QPPWSPPGTT PSSLDVFSSL FDSAEGSWSL
     PLADWDNEVD EYLTHLAMPR TANSEPLDAE GGITSSHNTS SNSPARPPTL QPVCPQLTCV
     AQSTFPAPGQ CRGTSPTLVL YLSQQCAGSV EAADHQRSAG RLHIRRPAR