ID   GELS1_PLARH             Reviewed;         377 AA.
AC   A0A6B9KZ40;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   17-JUN-2020, sequence version 1.
DT   03-AUG-2022, entry version 5.
DE   RecName: Full=Actin depolymerising venom protein gelsolin 1 {ECO:0000303|PubMed:31752210};
DE   Flags: Precursor;
OS   Platymeris rhadamanthus (Red spot assassin bug).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC   Cimicomorpha; Reduviidae; Platymeris.
OX   NCBI_TaxID=1134088;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY,
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=31752210; DOI=10.3390/toxins11110673;
RA   Walker A.A., Robinson S.D., Undheim E.A.B., Jin J., Han X., Fry B.G.,
RA   Vetter I., King G.F.;
RT   "Missiles of mass disruption: composition and glandular origin of venom
RT   used as a projectile defensive weapon by the assassin bug Platymeris
RT   rhadamanthus.";
RL   Toxins 11:E673-E673(2019).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31752210}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland (posterior main gland)
CC       (at protein level). {ECO:0000305|PubMed:31752210}.
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DR   EMBL; MN208317; QHB21506.1; -; mRNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   Gene3D; 3.40.20.10; -; 3.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR007123; Gelsolin-like_dom.
DR   InterPro; IPR007122; Villin/Gelsolin.
DR   PANTHER; PTHR11977; PTHR11977; 1.
DR   Pfam; PF00626; Gelsolin; 3.
DR   PRINTS; PR00597; GELSOLIN.
DR   SMART; SM00262; GEL; 3.
PE   1: Evidence at protein level;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..377
FT                   /note="Actin depolymerising venom protein gelsolin 1"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5025615264"
FT   REPEAT          50..133
FT                   /note="Gelsolin-like 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          174..243
FT                   /note="Gelsolin-like 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          298..368
FT                   /note="Gelsolin-like 3"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   377 AA;  42122 MW;  F54FA875283174CA CRC64;
     MFRQMKLGSL ATKLLLACFL VTCTSGLDIH PNLIGAGQKE GIEIWRIETF VPVPVPKSEY
     GKFHEGDSYI VLSTKEDKSK KGIFTWDIYY WLGKSTTQDE SGTAAVLTVE LDDALGKTPV
     QHREIQGQES EQFVKLFPGG VKYLPGGIDS GFKHTDTNAP GQKKLYQVKG AKYIRVRQVE
     LSAKSLNNGD CFILDTGSEV YVWVGKNSQL PERLKATKAA NQIKELDHRG RGKVFIVDAS
     STSREVKEFF TKLGSGSPSE VANTSEDDQE YEKKQDAMVT LYKVSDASGK LVTEKLSEKP
     LKQSMLKSED CFVLDTVTSG VFVWIGRNSS IQEKIEAFKK GLAFLKDNKH PTWTQMQRIV
     DGGEPTAFKE YFLSWKN