ID   GEMI6_BOVIN             Reviewed;         166 AA.
AC   Q2KHW8;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Gem-associated protein 6;
DE            Short=Gemin-6;
GN   Name=GEMIN6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The SMN complex catalyzes the assembly of small nuclear
CC       ribonucleoproteins (snRNPs), the building blocks of the spliceosome,
CC       and thereby plays an important role in the splicing of cellular pre-
CC       mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins
CC       SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in
CC       a heptameric protein ring on the Sm site of the small nuclear RNA to
CC       form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1,
CC       SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm
CC       complex by the chaperone CLNS1A that controls the assembly of the core
CC       snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm
CC       proteins from CLNS1A forming an intermediate. Binding of snRNA inside
CC       5Sm triggers eviction of the SMN complex, thereby allowing binding of
CC       SNRPD3 and SNRPB to complete assembly of the core snRNP (By
CC       similarity). {ECO:0000250|UniProtKB:Q8WXD5}.
CC   -!- SUBUNIT: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1,
CC       DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP.
CC       Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1,
CC       DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and
CC       the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG.
CC       Interacts with GEMIN7; the interaction is direct. Interacts with
CC       GEMIN8; the interaction is direct. Interacts with SNRPB, SNRPD2, SNRPD3
CC       and SNRPE; the interaction is direct. {ECO:0000250|UniProtKB:Q8WXD5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q8WXD5}. Nucleus, gem
CC       {ECO:0000250|UniProtKB:Q8WXD5}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8WXD5}. Note=Found both in the nucleoplasm and
CC       in nuclear bodies called gems (Gemini of Cajal bodies) that are often
CC       in proximity to Cajal (coiled) bodies. Also found in the cytoplasm (By
CC       similarity). {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC112855; AAI12856.1; -; mRNA.
DR   RefSeq; NP_001039743.1; NM_001046278.3.
DR   RefSeq; XP_010808250.1; XM_010809948.2.
DR   RefSeq; XP_010808251.1; XM_010809949.2.
DR   AlphaFoldDB; Q2KHW8; -.
DR   SMR; Q2KHW8; -.
DR   STRING; 9913.ENSBTAP00000020624; -.
DR   PaxDb; Q2KHW8; -.
DR   Ensembl; ENSBTAT00000020624; ENSBTAP00000020624; ENSBTAG00000015521.
DR   GeneID; 525263; -.
DR   KEGG; bta:525263; -.
DR   CTD; 79833; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015521; -.
DR   VGNC; VGNC:29319; GEMIN6.
DR   eggNOG; ENOG502RZTW; Eukaryota.
DR   GeneTree; ENSGT00390000006712; -.
DR   HOGENOM; CLU_127294_0_0_1; -.
DR   InParanoid; Q2KHW8; -.
DR   OMA; KSPLEWE; -.
DR   OrthoDB; 1625274at2759; -.
DR   TreeFam; TF314693; -.
DR   Reactome; R-BTA-191859; snRNP Assembly.
DR   Proteomes; UP000009136; Chromosome 11.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0097504; C:Gemini of coiled bodies; ISS:UniProtKB.
DR   GO; GO:0032797; C:SMN complex; ISS:UniProtKB.
DR   GO; GO:0034719; C:SMN-Sm protein complex; ISS:UniProtKB.
DR   GO; GO:0000245; P:spliceosomal complex assembly; IEA:InterPro.
DR   GO; GO:0000387; P:spliceosomal snRNP assembly; ISS:UniProtKB.
DR   InterPro; IPR009422; Gemin6.
DR   PANTHER; PTHR14710; PTHR14710; 1.
DR   Pfam; PF06372; Gemin6; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..166
FT                   /note="Gem-associated protein 6"
FT                   /id="PRO_0000244456"
FT   MOD_RES         94
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WXD5"
FT   MOD_RES         165
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WXD5"
SQ   SEQUENCE   166 AA;  18724 MW;  DF4D9ED023584EE9 CRC64;
     MNEWMKKGPL EWQDYTYKAV SVTASDKEYK GWVLTTDPVS ANIVLVNFLE DGSMSVTGIM
     GHAVQTVEIV NEGDHSVREK LMHLFMSGDC KAYSPEDLEK RKNSLKKWLE KNHIPITEQR
     DSRKTLCVAG VLTIDPPYGP ENCNSSNEII LSRVQDLIQG HLEASQ