GEMI6_SCHPO
ID GEMI6_SCHPO Reviewed; 93 AA.
AC G2TRK8;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 1.
DT 25-MAY-2022, entry version 29.
DE RecName: Full=Uncharacterized protein new12;
GN Name=gem6 {ECO:0000303|PubMed:33754639};
GN Synonyms=new12 {ECO:0000312|PomBase:SPAC4D7.15};
GN ORFNames=SPAC4D7.15 {ECO:0000312|PomBase:SPAC4D7.15};
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP IDENTIFICATION.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP IDENTIFICATION.
RX PubMed=21270388; DOI=10.1534/genetics.110.123497;
RA Bitton D.A., Wood V., Scutt P.J., Grallert A., Yates T., Smith D.L.,
RA Hagan I.M., Miller C.J.;
RT "Augmented annotation of the Schizosaccharomyces pombe genome reveals
RT additional genes required for growth and viability.";
RL Genetics 187:1207-1217(2011).
RN [4]
RP FUNCTION, IDENTIFICATION IN THE CORE SMN COMPLEX, INTERACTION WITH GEM7,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=33754639; DOI=10.1093/nar/gkab158;
RA Veepaschit J., Viswanathan A., Bordonne R., Grimm C., Fischer U.;
RT "Identification and structural analysis of the Schizosaccharomyces pombe
RT SMN complex.";
RL Nucleic Acids Res. 49:gkab158-gkab158(2021).
CC -!- FUNCTION: The SMN complex catalyzes the assembly of small nuclear
CC ribonucleoproteins (snRNPs), the building blocks of the spliceosome,
CC and thereby plays an important role in the splicing of cellular pre-
CC mRNAs (PubMed:33754639). Most spliceosomal snRNPs contain a common set
CC of Sm proteins smb1, smd1, smd2, smd3, sme1, smf1 and smg1 that
CC assemble in a heptameric protein ring on the Sm site of the small
CC nuclear RNA to form the core snRNP (Sm core) (By similarity). In the
CC cytosol, the Sm proteins smd1, smd2, sme1, smf1 and smg1 (5Sm) are
CC trapped in an inactive 6S pICln-Sm complex by the chaperone saf5 (By
CC similarity). To complete assembly of core snRNPs, the SMN complex
CC accepts 5Sm from saf5 (By similarity). Binding of snRNA inside 5Sm
CC triggers eviction of the SMN complex, thereby allowing binding of smd3
CC and smb1 to complete assembly of the core snRNP (By similarity).
CC {ECO:0000250|UniProtKB:Q8WXD5, ECO:0000269|PubMed:33754639}.
CC -!- SUBUNIT: Part of the core SMN complex at least composed of smn1,
CC yip11/gem2, gem6, gem7 and gem8 (PubMed:33754639). Interacts with gem7;
CC the interaction is direct (PubMed:33754639).
CC {ECO:0000269|PubMed:33754639}.
CC -!- DISRUPTION PHENOTYPE: Inviable cell population.
CC {ECO:0000269|PubMed:33754639}.
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DR EMBL; CU329670; CCD31345.1; -; Genomic_DNA.
DR RefSeq; XP_004001800.1; XM_004001751.1.
DR AlphaFoldDB; G2TRK8; -.
DR SASBDB; G2TRK8; -.
DR SMR; G2TRK8; -.
DR PaxDb; G2TRK8; -.
DR EnsemblFungi; SPAC4D7.15.1; SPAC4D7.15.1:pep; SPAC4D7.15.
DR PomBase; SPAC4D7.15; gem6.
DR VEuPathDB; FungiDB:SPAC4D7.15; -.
DR HOGENOM; CLU_2334840_0_0_1; -.
DR OMA; YSIMSDA; -.
DR PRO; PR:G2TRK8; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0032797; C:SMN complex; IDA:PomBase.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; IMP:PomBase.
PE 2: Evidence at transcript level;
KW mRNA processing; mRNA splicing; Reference proteome.
FT CHAIN 1..93
FT /note="Uncharacterized protein new12"
FT /id="PRO_0000416506"
SQ SEQUENCE 93 AA; 10623 MW; DDA0B5EA7C9739EF CRC64;
MDSHTTEKRR GSYLRVLFKN GRLPVEGFLW NCDPLTGTLI LIQPLTPNTD EVEDTHYRFY
GIMSDAIQTI EPDESMSPLN QQSLAEYDSL LTS
