GEMI8_HUMAN
ID GEMI8_HUMAN Reviewed; 242 AA.
AC Q9NWZ8; C4AMC4; Q2LJ66; Q6ZV27;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Gem-associated protein 8;
DE Short=Gemin-8;
DE AltName: Full=Protein FAM51A1;
GN Name=GEMIN8; Synonyms=FAM51A1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN SMN COMPLEX, SUBCELLULAR
RP LOCATION, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=16434402; DOI=10.1074/jbc.m512243200;
RA Carissimi C., Saieva L., Baccon J., Chiarella P., Maiolica A., Sawyer A.,
RA Rappsilber J., Pellizzoni L.;
RT "Gemin8 is a novel component of the survival motor neuron complex and
RT functions in small nuclear ribonucleoprotein assembly.";
RL J. Biol. Chem. 281:8126-8134(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastric carcinoma, and Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP FUNCTION, AND INTERACTION WITH SMN1; GEMIN6 AND GEMIN7.
RX PubMed=17023415; DOI=10.1074/jbc.m607505200;
RA Carissimi C., Saieva L., Gabanella F., Pellizzoni L.;
RT "Gemin8 is required for the architecture and function of the survival motor
RT neuron complex.";
RL J. Biol. Chem. 281:37009-37016(2006).
RN [8]
RP IDENTIFICATION IN THE SMN COMPLEX, AND INTERACTION WITH GEMIN7; SMN1 AND
RP GEMIN4.
RX PubMed=17178713; DOI=10.1074/jbc.m608528200;
RA Otter S., Grimmler M., Neuenkirchen N., Chari A., Sickmann A., Fischer U.;
RT "A comprehensive interaction map of the human survival of motor neuron
RT (SMN) complex.";
RL J. Biol. Chem. 282:5825-5833(2007).
RN [9]
RP FUNCTION IN SNRNP BIOGENESIS, AND IDENTIFICATION IN SMN-SM COMPLEX.
RX PubMed=18984161; DOI=10.1016/j.cell.2008.09.020;
RA Chari A., Golas M.M., Klingenhager M., Neuenkirchen N., Sander B.,
RA Englbrecht C., Sickmann A., Stark H., Fischer U.;
RT "An assembly chaperone collaborates with the SMN complex to generate
RT spliceosomal SnRNPs.";
RL Cell 135:497-509(2008).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-124 AND SER-126, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [12] {ECO:0007744|PDB:7BBL}
RP X-RAY CRYSTALLOGRAPHY (1.52 ANGSTROMS) OF 191-230, AND INTERACTION WITH
RP SMN1; GEMIN7 AND GEMIN6.
RX PubMed=33754639; DOI=10.1093/nar/gkab158;
RA Veepaschit J., Viswanathan A., Bordonne R., Grimm C., Fischer U.;
RT "Identification and structural analysis of the Schizosaccharomyces pombe
RT SMN complex.";
RL Nucleic Acids Res. 49:gkab158-gkab158(2021).
CC -!- FUNCTION: The SMN complex catalyzes the assembly of small nuclear
CC ribonucleoproteins (snRNPs), the building blocks of the spliceosome,
CC and thereby plays an important role in the splicing of cellular pre-
CC mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins
CC SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in
CC a heptameric protein ring on the Sm site of the small nuclear RNA to
CC form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1,
CC SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm
CC complex by the chaperone CLNS1A that controls the assembly of the core
CC snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm
CC proteins from CLNS1A forming an intermediate. Binding of snRNA inside
CC 5Sm triggers eviction of the SMN complex, thereby allowing binding of
CC SNRPD3 and SNRPB to complete assembly of the core snRNP.
CC {ECO:0000269|PubMed:17023415, ECO:0000269|PubMed:18984161}.
CC -!- SUBUNIT: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1,
CC DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP
CC (PubMed:16434402, PubMed:18984161, PubMed:17178713). Part of the SMN-Sm
CC complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5,
CC GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1,
CC SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG (PubMed:18984161). Interacts
CC with GEMIN6; the interaction is direct (PubMed:33754639,
CC PubMed:17023415). Interacts with GEMIN7; the interaction is direct
CC (PubMed:33754639, PubMed:17023415, PubMed:17178713). Interacts with
CC SMN1; the interaction is direct (PubMed:17023415, PubMed:33754639,
CC PubMed:17178713). Interacts with GEMIN4; the interaction is direct
CC (PubMed:17178713). {ECO:0000269|PubMed:16434402,
CC ECO:0000269|PubMed:17023415, ECO:0000269|PubMed:17178713,
CC ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:33754639}.
CC -!- INTERACTION:
CC Q9NWZ8; Q12926-2: ELAVL2; NbExp=3; IntAct=EBI-2626001, EBI-11075944;
CC Q9NWZ8; Q96HC4-3: PDLIM5; NbExp=3; IntAct=EBI-2626001, EBI-25913059;
CC Q9NWZ8; A0A024R8L5: WIPI1; NbExp=3; IntAct=EBI-2626001, EBI-25923668;
CC -!- SUBCELLULAR LOCATION: Nucleus, gem {ECO:0000269|PubMed:16434402}.
CC Cytoplasm {ECO:0000269|PubMed:16434402}. Note=Found in nuclear bodies
CC called gems (Gemini of Cajal bodies) that are often in proximity to
CC Cajal (coiled) bodies. Also found in the cytoplasm.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC86038.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; DQ224033; ABB46495.1; -; mRNA.
DR EMBL; AK000521; BAA91227.1; -; mRNA.
DR EMBL; AK125062; BAC86038.1; ALT_INIT; mRNA.
DR EMBL; CR457241; CAG33522.1; -; mRNA.
DR EMBL; AC003035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471074; EAW98851.1; -; Genomic_DNA.
DR EMBL; BC003607; AAH03607.1; -; mRNA.
DR EMBL; BC014324; AAH14324.1; -; mRNA.
DR EMBL; BC020785; AAH20785.1; -; mRNA.
DR CCDS; CCDS14159.1; -.
DR RefSeq; NP_001035944.1; NM_001042479.1.
DR RefSeq; NP_001035945.1; NM_001042480.1.
DR RefSeq; NP_060326.1; NM_017856.2.
DR RefSeq; XP_016885106.1; XM_017029617.1.
DR RefSeq; XP_016885107.1; XM_017029618.1.
DR PDB; 7BBL; X-ray; 1.52 A; E/F=191-230.
DR PDBsum; 7BBL; -.
DR AlphaFoldDB; Q9NWZ8; -.
DR SMR; Q9NWZ8; -.
DR BioGRID; 120298; 59.
DR ComplexPortal; CPX-6031; SMN complex.
DR CORUM; Q9NWZ8; -.
DR IntAct; Q9NWZ8; 27.
DR MINT; Q9NWZ8; -.
DR STRING; 9606.ENSP00000369895; -.
DR iPTMnet; Q9NWZ8; -.
DR PhosphoSitePlus; Q9NWZ8; -.
DR BioMuta; GEMIN8; -.
DR DMDM; 52782795; -.
DR EPD; Q9NWZ8; -.
DR jPOST; Q9NWZ8; -.
DR MassIVE; Q9NWZ8; -.
DR MaxQB; Q9NWZ8; -.
DR PaxDb; Q9NWZ8; -.
DR PeptideAtlas; Q9NWZ8; -.
DR PRIDE; Q9NWZ8; -.
DR ProteomicsDB; 83006; -.
DR Antibodypedia; 23884; 254 antibodies from 22 providers.
DR DNASU; 54960; -.
DR Ensembl; ENST00000380523.8; ENSP00000369895.4; ENSG00000046647.14.
DR Ensembl; ENST00000398355.7; ENSP00000381398.3; ENSG00000046647.14.
DR Ensembl; ENST00000477386.2; ENSP00000505279.1; ENSG00000046647.14.
DR Ensembl; ENST00000680255.1; ENSP00000505429.1; ENSG00000046647.14.
DR GeneID; 54960; -.
DR KEGG; hsa:54960; -.
DR MANE-Select; ENST00000680255.1; ENSP00000505429.1; NM_001042479.2; NP_001035944.1.
DR UCSC; uc004cwb.4; human.
DR CTD; 54960; -.
DR DisGeNET; 54960; -.
DR GeneCards; GEMIN8; -.
DR HGNC; HGNC:26044; GEMIN8.
DR HPA; ENSG00000046647; Low tissue specificity.
DR MIM; 300962; gene.
DR neXtProt; NX_Q9NWZ8; -.
DR OpenTargets; ENSG00000046647; -.
DR PharmGKB; PA162389344; -.
DR VEuPathDB; HostDB:ENSG00000046647; -.
DR eggNOG; ENOG502S7KA; Eukaryota.
DR GeneTree; ENSGT00390000013608; -.
DR HOGENOM; CLU_073610_0_0_1; -.
DR InParanoid; Q9NWZ8; -.
DR OMA; RAYARYW; -.
DR OrthoDB; 1593621at2759; -.
DR PhylomeDB; Q9NWZ8; -.
DR TreeFam; TF328591; -.
DR PathwayCommons; Q9NWZ8; -.
DR Reactome; R-HSA-191859; snRNP Assembly.
DR Reactome; R-HSA-9754678; SARS-CoV-2 modulates host translation machinery.
DR SignaLink; Q9NWZ8; -.
DR BioGRID-ORCS; 54960; 289 hits in 642 CRISPR screens.
DR GeneWiki; GEMIN8; -.
DR GenomeRNAi; 54960; -.
DR Pharos; Q9NWZ8; Tbio.
DR PRO; PR:Q9NWZ8; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9NWZ8; protein.
DR Bgee; ENSG00000046647; Expressed in right uterine tube and 151 other tissues.
DR ExpressionAtlas; Q9NWZ8; baseline and differential.
DR Genevisible; Q9NWZ8; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR GO; GO:0097504; C:Gemini of coiled bodies; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0032797; C:SMN complex; IDA:UniProtKB.
DR GO; GO:0034719; C:SMN-Sm protein complex; IDA:UniProtKB.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; IDA:UniProtKB.
DR InterPro; IPR034754; GEMIN8.
DR PANTHER; PTHR16238; PTHR16238; 1.
DR Pfam; PF15348; GEMIN8; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Coiled coil; Cytoplasm; mRNA processing; mRNA splicing;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..242
FT /note="Gem-associated protein 8"
FT /id="PRO_0000087155"
FT REGION 94..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 135..168
FT /evidence="ECO:0000255"
FT COMPBIAS 94..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 117
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 124
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 126
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT VARIANT 195
FT /note="E -> V (in dbSNP:rs3747421)"
FT /id="VAR_051011"
FT HELIX 195..205
FT /evidence="ECO:0007829|PDB:7BBL"
FT HELIX 206..208
FT /evidence="ECO:0007829|PDB:7BBL"
FT HELIX 209..225
FT /evidence="ECO:0007829|PDB:7BBL"
SQ SEQUENCE 242 AA; 28637 MW; 1D82C932F1A930A2 CRC64;
MAAVKASTSK ATRPWYSHPV YARYWQHYHQ AMAWMQSHHN AYRKAVESCF NLPWYLPSAL
LPQSSYDNEA AYPQSFYDHH VAWQDYPCSS SHFRRSGQHP RYSSRIQAST KEDQALSKEE
EMETESDAEV ECDLSNMEIT EELRQYFAET ERHREERRRQ QQLDAERLDS YVNADHDLYC
NTRRSVEAPT ERPGERRQAE MKRLYGDSAA KIQAMEAAVQ LSFDKHCDRK QPKYWPVIPL
KF
