ID   GEND1_ACAGO             Reviewed;          91 AA.
AC   P0DQJ4;
DT   13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2019, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=U1-theraphotoxin-Agm2a {ECO:0000303|PubMed:27436114};
DE            Short=U1-TRTX-Agm2a {ECO:0000303|PubMed:27436114};
DE   AltName: Full=Genicutoxin-D1-like protein {ECO:0000305|PubMed:27436114};
DE   Flags: Precursor;
OS   Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Acanthoscurria.
OX   NCBI_TaxID=115339;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=27436114; DOI=10.1016/j.jprot.2016.07.012;
RA   Abreu T.F., Sumitomo B.N., Nishiyama M.Y. Jr., Oliveira U.C., Souza G.H.,
RA   Kitano E.S., Zelanis A., Serrano S.M., Junqueira-de-Azevedo I.,
RA   Silva P.I. Jr., Tashima A.K.;
RT   "Peptidomics of Acanthoscurria gomesiana spider venom reveals new toxins
RT   with potential antimicrobial activity.";
RL   J. Proteomics 151:232-242(2017).
CC   -!- FUNCTION: Putative ion channel inhibitor that may also act as a
CC       antimicrobial peptide. {ECO:0000305|PubMed:27436114}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27436114}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:27436114}.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000269|PubMed:27436114}.
CC   -!- MASS SPECTROMETRY: Mass=3864.7; Method=Electrospray; Note=Monoisotopic
CC       mass.; Evidence={ECO:0000269|PubMed:27436114};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P0DQJ4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antimicrobial; Disulfide bond; Ion channel impairing toxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   PROPEP          33..56
FT                   /evidence="ECO:0000305|PubMed:27436114"
FT                   /id="PRO_0000448547"
FT   CHAIN           57..91
FT                   /note="U1-theraphotoxin-Agm2a"
FT                   /evidence="ECO:0000269|PubMed:27436114"
FT                   /id="PRO_0000448548"
SQ   SEQUENCE   91 AA;  10236 MW;  C70F4AD61E005157 CRC64;
     SFRFFEEIIM RLATLLGLSV LHLALCVLTC TAHHPGLEKS RVSYENMGDE ENAEERSCVH
     ERETCSKVRG PLCCRGECIC PIYGDCFCYG S