ID   ALPS_TACTR              Reviewed;         102 AA.
AC   P07087;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Anti-lipopolysaccharide factor;
DE            Short=anti-LPS;
OS   Tachypleus tridentatus (Japanese horseshoe crab).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Merostomata;
OC   Xiphosura; Limulidae; Tachypleus.
OX   NCBI_TaxID=6853;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3711091; DOI=10.1016/s0021-9258(17)38399-0;
RA   Aketagawa J., Miyata T., Ohtsubo S., Nakamura T., Morita T., Hayashida H.,
RA   Iwanaga S., Takao T., Shimonishi Y.;
RT   "Primary structure of limulus anticoagulant anti-lipopolysaccharide
RT   factor.";
RL   J. Biol. Chem. 261:7357-7365(1986).
CC   -!- FUNCTION: Binds tightly to LPS and thus specifically inhibits the LPS-
CC       mediated activation of the hemolymph coagulation. It has a strong
CC       antibacterial effect especially on the growth of Gram-negative
CC       bacteria.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; A23931; A23931.
DR   AlphaFoldDB; P07087; -.
DR   SMR; P07087; -.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.160.320; -; 1.
DR   InterPro; IPR024509; Anti-LPS_factor/Scygonadin.
DR   InterPro; IPR038539; Anti-LPS_factor/Scygonadin_sf.
DR   Pfam; PF11630; DUF3254; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Disulfide bond.
FT   CHAIN           1..102
FT                   /note="Anti-lipopolysaccharide factor"
FT                   /id="PRO_0000064573"
FT   DISULFID        32..53
FT   VARIANT         36
FT                   /note="V -> I"
FT   VARIANT         102
FT                   /note="E -> Q"
SQ   SEQUENCE   102 AA;  11596 MW;  7FB76B00B296F349 CRC64;
     EGGIWTQLAL ALVKNLATLW QSGDFQFLGH ECHYRVNPTV KRLKWKYKGK FWCPSWTSIT
     GRATKSSRSG AVEHSVRDFV SQAKSSGLIT EKEAQTFISQ YE