GERM_BACSU
ID GERM_BACSU Reviewed; 366 AA.
AC P39072; P94557;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Spore germination protein GerM;
GN Name=gerM; OrderedLocusNames=BSU28380;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=8969504; DOI=10.1099/13500872-142-11-3067;
RA Wipat A., Carter N., Brignell C.S., Guy J.B., Piper K., Sanders J.,
RA Emmerson P.T., Harwood C.R.;
RT "The dnaB-pheA (256 degrees-240 degrees) region of the Bacillus subtilis
RT chromosome containing genes responsible for stress responses, the
RT utilization of plant cell walls and primary metabolism.";
RL Microbiology 142:3067-3078(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-210.
RC STRAIN=168;
RX PubMed=7926687; DOI=10.1111/j.1574-6968.1994.tb07119.x;
RA Slynn G.M., Sammons R.L., Smith D.A., Moir A., Corfe B.M.;
RT "Molecular genetical and phenotypical analysis of the gerM spore
RT germination gene of Bacillus subtilis 168.";
RL FEMS Microbiol. Lett. 121:315-320(1994).
RN [4]
RP CHARACTERIZATION.
RX PubMed=2846748; DOI=10.1099/00221287-133-12-3299;
RA Sammons R.L., Slynn G.M., Smith D.A.;
RT "Genetical and molecular studies on gerM, a new developmental locus of
RT Bacillus subtilis.";
RL J. Gen. Microbiol. 133:3299-3312(1987).
CC -!- FUNCTION: Unknown. Affects both sporulation and germination.
CC -!- DEVELOPMENTAL STAGE: Expressed shortly after the beginning of
CC sporulation.
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DR EMBL; Z75208; CAA99553.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14798.1; -; Genomic_DNA.
DR EMBL; M65162; AAA65726.1; -; Genomic_DNA.
DR PIR; C69631; C69631.
DR RefSeq; NP_390716.1; NC_000964.3.
DR RefSeq; WP_003229578.1; NZ_JNCM01000036.1.
DR PDB; 6GZ8; X-ray; 1.00 A; A=76-213.
DR PDB; 6GZB; X-ray; 2.10 A; A/B/C/D=26-366.
DR PDBsum; 6GZ8; -.
DR PDBsum; 6GZB; -.
DR AlphaFoldDB; P39072; -.
DR SMR; P39072; -.
DR STRING; 224308.BSU28380; -.
DR PaxDb; P39072; -.
DR PRIDE; P39072; -.
DR EnsemblBacteria; CAB14798; CAB14798; BSU_28380.
DR GeneID; 936490; -.
DR KEGG; bsu:BSU28380; -.
DR PATRIC; fig|224308.179.peg.3083; -.
DR eggNOG; COG5401; Bacteria.
DR OMA; TWTLTQF; -.
DR BioCyc; BSUB:BSU28380-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR InterPro; IPR019606; GerMN.
DR Pfam; PF10646; Germane; 2.
DR SMART; SM00909; Germane; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Germination; Reference proteome; Sporulation.
FT CHAIN 1..366
FT /note="Spore germination protein GerM"
FT /id="PRO_0000087465"
FT REGION 42..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 210
FT /note="I -> T (in Ref. 3; AAA65726)"
FT /evidence="ECO:0000305"
FT STRAND 77..84
FT /evidence="ECO:0007829|PDB:6GZ8"
FT STRAND 90..97
FT /evidence="ECO:0007829|PDB:6GZ8"
FT HELIX 103..109
FT /evidence="ECO:0007829|PDB:6GZ8"
FT HELIX 116..120
FT /evidence="ECO:0007829|PDB:6GZ8"
FT STRAND 135..139
FT /evidence="ECO:0007829|PDB:6GZ8"
FT STRAND 143..149
FT /evidence="ECO:0007829|PDB:6GZ8"
FT HELIX 151..154
FT /evidence="ECO:0007829|PDB:6GZ8"
FT HELIX 158..160
FT /evidence="ECO:0007829|PDB:6GZ8"
FT HELIX 161..173
FT /evidence="ECO:0007829|PDB:6GZ8"
FT STRAND 179..185
FT /evidence="ECO:0007829|PDB:6GZ8"
FT TURN 194..196
FT /evidence="ECO:0007829|PDB:6GZ8"
FT STRAND 202..204
FT /evidence="ECO:0007829|PDB:6GZ8"
FT HELIX 206..208
FT /evidence="ECO:0007829|PDB:6GZB"
FT STRAND 222..233
FT /evidence="ECO:0007829|PDB:6GZB"
FT STRAND 238..248
FT /evidence="ECO:0007829|PDB:6GZB"
FT HELIX 254..264
FT /evidence="ECO:0007829|PDB:6GZB"
FT STRAND 282..284
FT /evidence="ECO:0007829|PDB:6GZB"
FT STRAND 287..289
FT /evidence="ECO:0007829|PDB:6GZB"
FT STRAND 292..297
FT /evidence="ECO:0007829|PDB:6GZB"
FT HELIX 299..301
FT /evidence="ECO:0007829|PDB:6GZB"
FT HELIX 314..324
FT /evidence="ECO:0007829|PDB:6GZB"
FT STRAND 332..337
FT /evidence="ECO:0007829|PDB:6GZB"
FT STRAND 359..363
FT /evidence="ECO:0007829|PDB:6GZB"
SQ SEQUENCE 366 AA; 39573 MW; 746840393001FDE9 CRC64;
MLKKGPAVIG ATCLTSALLL SGCGLFQSDK AAEEIDPPQD VTFVNDEAGA NSNTTAAKKT
ESEKSDTAKA DQASSTVMRE LYLIDKNGYV VAQTLPLPKS ESTAKQALEY LVQGGPVSEI
LPNGFRAVLP ADTTVNVDIK KDGTAIADFS NEFKNYKKED EQKIVQSVTW TLTQFSSIDK
VKLRINGHEL KEMPVGGTPI SDDLSRKDGI NLETAGVNDL TATHPLTVYY LAENEDSEYY
VPVTKRIDNS EKDDITAAIN ELAKGPSKVS GLLTDFSEDV KLVSKPKIKD GRVTLDFNQS
IFGSADEKTK MISSEVLNSI VLTLTEQPDV KSVSVKVNGK SELVNEKGEK LTEPVSRPSQ
VNTGSF
