ID   GERT_BACCE              Reviewed;         375 AA.
AC   B3VQ24;
DT   19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Probable Na(+)/H(+) antiporter GerT;
GN   Name=gerT;
OS   Bacillus cereus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1396;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND GENE NAME.
RC   STRAIN=ATCC 10876 / DSM 9378 / NRRL B-569;
RX   PubMed=18641133; DOI=10.1128/jb.00789-08;
RA   Senior A., Moir A.;
RT   "The Bacillus cereus GerN and GerT protein homologs have distinct roles in
RT   spore germination and outgrowth, respectively.";
RL   J. Bacteriol. 190:6148-6152(2008).
CC   -!- FUNCTION: Contributes to the success of spore outgrowth from the
CC       germinated state during alkaline or Na(+) stress. Does not have a
CC       significant role in germination. {ECO:0000269|PubMed:18641133}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC       transporter (TC 2.A.37) family. {ECO:0000305}.
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DR   EMBL; EU789572; ACF08934.1; -; Genomic_DNA.
DR   RefSeq; WP_001985966.1; NZ_VEFJ01000002.1.
DR   AlphaFoldDB; B3VQ24; -.
DR   SMR; B3VQ24; -.
DR   STRING; 1396.DJ87_4263; -.
DR   eggNOG; COG0475; Bacteria.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR004771; K/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   TIGRFAMs; TIGR00932; 2a37; 1.
PE   3: Inferred from homology;
KW   Antiport; Ion transport; Membrane; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..375
FT                   /note="Probable Na(+)/H(+) antiporter GerT"
FT                   /id="PRO_0000425691"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   375 AA;  40381 MW;  B3573E018A4C1E69 CRC64;
     MLFYFELVVI LLCTKLAGDI SVRLGQPSVL GKLIVGIIIG PAVLGIINSS ELIDELSEIG
     VLLLMFMAGL ETDLEELNRN LKSSFAVAAG GIIFPFIGGY VTGLLFGLIQ SHAIFLGLLL
     CATSVSITVQ TLRDLGKMNT RESTTILGAA VFDDVIVVIL LAFVMSFLGT QDVNITLVIV
     KKIIFFVSIV FIAWKVVPWI MKMLVPLRVT EALISAALII CFSFSYYSEM MGIAGIIGAF
     AAGIAISQTE YKHEVEHKIE PIAYAIFVPV FFVSIGMEIT FQGIGSQLWF IIIMTLIAIF
     TKLIGSGLGA RLTGFNLQSS ISIGAGMVSR GEVALIIAAN GLTANLLAKE NFTAIVIVVI
     LTTIITPPLL KKYFV