GERXB_BACAN
ID GERXB_BACAN Reviewed; 355 AA.
AC Q9ZFB5; Q8KYK7;
DT 24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 25-MAY-2022, entry version 130.
DE RecName: Full=Spore germination protein XB;
GN Name=gerXB; OrderedLocusNames=pXO1-114, BXA0156, GBAA_pXO1_0156;
OS Bacillus anthracis.
OG Plasmid pXO1.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sterne;
RX PubMed=10411756; DOI=10.1046/j.1365-2958.1999.01485.x;
RA Guidi-Rontani C., Pereira Y., Ruffie S., Sirard J.-C., Weber-Levy M.,
RA Mock M.;
RT "Identification and characterization of a germination operon on the
RT virulence plasmid pXO1 of Bacillus anthracis.";
RL Mol. Microbiol. 33:407-414(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RX PubMed=10515943; DOI=10.1128/jb.181.20.6509-6515.1999;
RA Okinaka R.T., Cloud K., Hampton O., Hoffmaster A.R., Hill K.K., Keim P.,
RA Koehler T.M., Lamke G., Kumano S., Mahillon J., Manter D., Martinez Y.,
RA Ricke D., Svensson R., Jackson P.J.;
RT "Sequence and organization of pXO1, the large Bacillus anthracis plasmid
RT harboring the anthrax toxin genes.";
RL J. Bacteriol. 181:6509-6515(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Ames / isolate Florida / A2012;
RX PubMed=12004073; DOI=10.1126/science.1071837;
RA Read T.D., Salzberg S.L., Pop M., Shumway M.F., Umayam L., Jiang L.,
RA Holtzapple E., Busch J.D., Smith K.L., Schupp J.M., Solomon D., Keim P.,
RA Fraser C.M.;
RT "Comparative genome sequencing for discovery of novel polymorphisms in
RT Bacillus anthracis.";
RL Science 296:2028-2033(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Carbosap, and Ferrara;
RX PubMed=12067380; DOI=10.1046/j.1365-2672.2002.01660.x;
RA Adone R., Pasquali P., La Rosa G., Marianelli C., Muscillo M.,
RA Fasanella A., Francia M., Ciuchini F.;
RT "Sequence analysis of the genes encoding for the major virulence factors of
RT Bacillus anthracis vaccine strain 'Carbosap'.";
RL J. Appl. Microbiol. 93:117-121(2002).
CC -!- FUNCTION: May allow B.anthracis to germinate within phagocytic cells
CC and therefore involved in virulence.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC99414.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAD32418.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAC93926.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAC93929.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF108144; AAC99414.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF065404; AAD32418.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE011190; AAM26101.1; -; Genomic_DNA.
DR EMBL; AE017336; AAT28897.2; -; Genomic_DNA.
DR EMBL; AJ413932; CAC93926.1; ALT_INIT; Genomic_DNA.
DR EMBL; AJ413933; CAC93929.1; ALT_INIT; Genomic_DNA.
DR PIR; B59105; B59105.
DR RefSeq; NP_052810.1; NC_001496.1.
DR RefSeq; WP_001118850.1; NZ_QAEM01000007.1.
DR AlphaFoldDB; Q9ZFB5; -.
DR SMR; Q9ZFB5; -.
DR EnsemblBacteria; AAT28897; AAT28897; GBAA_pXO1_0156.
DR KEGG; bar:GBAA_pXO1_0156; -.
DR HOGENOM; CLU_047547_1_2_9; -.
DR Proteomes; UP000000594; Plasmid pXO1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR GO; GO:0009847; P:spore germination; IEA:InterPro.
DR InterPro; IPR004761; Spore_GerAB.
DR PANTHER; PTHR34975; PTHR34975; 1.
DR Pfam; PF03845; Spore_permease; 1.
DR TIGRFAMs; TIGR00912; 2A0309; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell membrane; Germination; Membrane; Plasmid;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW Virulence.
FT CHAIN 1..355
FT /note="Spore germination protein XB"
FT /id="PRO_0000054257"
FT TRANSMEM 2..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..348
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 355 AA; 40408 MW; 1CEBA428FC3CB87B CRC64;
MVNFFQIALV LIGSTGIINH VIIIPMLLDH SGRDSWISII ILSLVYIIWI PCVFIVHKYT
REEHLFSWLM RNYGGFITYP LLSIIVLYLI ILGTVTLKET LTFFSFYLPE TPRILLGVLL
SIICFYNIQR GVQSIALTTG ILLPVVFLLG FFVMIANFPH KDYSLLKPIM EHGMDPVIKG
MIYPAAGFVE LIFILFLQHH IGSKIKLSQL IIVGIILAGI TLGPTIAAIV EFGPFVAANQ
RYPTFEEWRL VSIGKYIEHL DFLSVYQWLV GVFIRISLVI FLIPDVLQVT KQKARNQIIS
ILLICMVIIC ILPISDASFY WFLSHVFLPI SAIGLFLFSM LLLVFVWVSK NKKRA
