GERXC_BACAN
ID GERXC_BACAN Reviewed; 317 AA.
AC Q9ZFB3; Q933Z4; Q9RQU1;
DT 24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 3.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Spore germination protein XC;
DE Flags: Precursor;
GN Name=gerXC; OrderedLocusNames=pXO1-112, BXA0158, GBAA_pXO1_0158;
OS Bacillus anthracis.
OG Plasmid pXO1.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sterne;
RX PubMed=10411756; DOI=10.1046/j.1365-2958.1999.01485.x;
RA Guidi-Rontani C., Pereira Y., Ruffie S., Sirard J.-C., Weber-Levy M.,
RA Mock M.;
RT "Identification and characterization of a germination operon on the
RT virulence plasmid pXO1 of Bacillus anthracis.";
RL Mol. Microbiol. 33:407-414(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RX PubMed=10515943; DOI=10.1128/jb.181.20.6509-6515.1999;
RA Okinaka R.T., Cloud K., Hampton O., Hoffmaster A.R., Hill K.K., Keim P.,
RA Koehler T.M., Lamke G., Kumano S., Mahillon J., Manter D., Martinez Y.,
RA Ricke D., Svensson R., Jackson P.J.;
RT "Sequence and organization of pXO1, the large Bacillus anthracis plasmid
RT harboring the anthrax toxin genes.";
RL J. Bacteriol. 181:6509-6515(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Ames / isolate Florida / A2012;
RX PubMed=12004073; DOI=10.1126/science.1071837;
RA Read T.D., Salzberg S.L., Pop M., Shumway M.F., Umayam L., Jiang L.,
RA Holtzapple E., Busch J.D., Smith K.L., Schupp J.M., Solomon D., Keim P.,
RA Fraser C.M.;
RT "Comparative genome sequencing for discovery of novel polymorphisms in
RT Bacillus anthracis.";
RL Science 296:2028-2033(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Carbosap, and Ferrara;
RX PubMed=12067380; DOI=10.1046/j.1365-2672.2002.01660.x;
RA Adone R., Pasquali P., La Rosa G., Marianelli C., Muscillo M.,
RA Fasanella A., Francia M., Ciuchini F.;
RT "Sequence analysis of the genes encoding for the major virulence factors of
RT Bacillus anthracis vaccine strain 'Carbosap'.";
RL J. Appl. Microbiol. 93:117-121(2002).
CC -!- FUNCTION: May allow B.anthracis to germinate within phagocytic cells
CC and therefore involved in virulence.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the GerABKC lipoprotein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC99416.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAD32416.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAC93928.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAC93931.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF108144; AAC99416.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF065404; AAD32416.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE011190; AAM26103.1; -; Genomic_DNA.
DR EMBL; AE017336; AAT28899.2; -; Genomic_DNA.
DR EMBL; AJ413932; CAC93928.1; ALT_INIT; Genomic_DNA.
DR EMBL; AJ413933; CAC93931.1; ALT_INIT; Genomic_DNA.
DR PIR; H59104; H59104.
DR RefSeq; NP_052808.1; NC_001496.1.
DR RefSeq; WP_003159771.1; NZ_VTZH01000015.1.
DR RefSeq; WP_010890027.1; NC_001496.1.
DR AlphaFoldDB; Q9ZFB3; -.
DR EnsemblBacteria; AAT28899; AAT28899; GBAA_pXO1_0158.
DR GeneID; 45025510; -.
DR KEGG; bar:GBAA_pXO1_0158; -.
DR HOGENOM; CLU_051140_2_0_9; -.
DR OMA; WVYATDE; -.
DR Proteomes; UP000000594; Plasmid pXO1.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009847; P:spore germination; IEA:InterPro.
DR InterPro; IPR008844; Spore_GerAC.
DR PANTHER; PTHR35789; PTHR35789; 1.
DR Pfam; PF05504; Spore_GerAC; 1.
DR TIGRFAMs; TIGR02887; spore_ger_x_C; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane; Germination; Lipoprotein; Membrane; Palmitate; Plasmid;
KW Reference proteome; Signal; Virulence.
FT SIGNAL 1..20
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 21..317
FT /note="Spore germination protein XC"
FT /id="PRO_0000018176"
FT LIPID 21
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000305"
FT LIPID 21
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000305"
FT CONFLICT 316
FT /note="K -> R (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 317 AA; 36977 MW; 060F92601842D6B2 CRC64;
MKINRKGGLF LLMFLFLLTG CWDRRELEHV LFINTLGIDF KDNHYIIYPQ FINFTNMAKQ
EGPANRNYSP AYIGKGEGKL LYDAAFDFYK SSQQKVSWEH IKSIVVTERF LKNGNLNQLN
DFLSRFFQFR NTMWVFGTKE PLENILATNN IFNISSLYTI MNLPQETIRQ SASVDPLRLY
TFRSNYYEPG MTTRIPFLAT TTEHWKQGHK AFWMLEFNEY GCIAAKSYVN HLNDSDIAGV
RWTNKNTNRA PLLLKVKNRA IGELILKKPK IDTKVSIEKG KPHIVMNISL EGDIYQLMKP
MPVHKVKKTL RISLKKK
