ID   GET1_MALGO              Reviewed;         222 AA.
AC   A8PTK5;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Protein GET1;
DE   AltName: Full=Guided entry of tail-anchored proteins 1;
GN   Name=GET1; ORFNames=MGL_0439;
OS   Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX   NCBI_TaxID=425265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4612 / CBS 7966;
RX   PubMed=18000048; DOI=10.1073/pnas.0706756104;
RA   Xu J., Saunders C.W., Hu P., Grant R.A., Boekhout T., Kuramae E.E.,
RA   Kronstad J.W., DeAngelis Y.M., Reeder N.L., Johnstone K.R., Leland M.,
RA   Fieno A.M., Begley W.M., Sun Y., Lacey M.P., Chaudhary T., Keough T.,
RA   Chu L., Sears R., Yuan B., Dawson T.L. Jr.;
RT   "Dandruff-associated Malassezia genomes reveal convergent and divergent
RT   virulence traits shared with plant and human fungal pathogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:18730-18735(2007).
CC   -!- FUNCTION: Required for the post-translational delivery of tail-anchored
CC       (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor
CC       for soluble GET3, which recognizes and selectively binds the
CC       transmembrane domain of TA proteins in the cytosol (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with GET3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WRB/GET1 family. {ECO:0000305}.
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DR   EMBL; AAYY01000001; EDP45450.1; -; Genomic_DNA.
DR   RefSeq; XP_001732664.1; XM_001732612.1.
DR   AlphaFoldDB; A8PTK5; -.
DR   SMR; A8PTK5; -.
DR   STRING; 425265.A8PTK5; -.
DR   EnsemblFungi; EDP45450; EDP45450; MGL_0439.
DR   GeneID; 5856970; -.
DR   KEGG; mgl:MGL_0439; -.
DR   VEuPathDB; FungiDB:MGL_0439; -.
DR   InParanoid; A8PTK5; -.
DR   OrthoDB; 1498067at2759; -.
DR   Proteomes; UP000008837; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; IEA:InterPro.
DR   Gene3D; 1.10.287.660; -; 1.
DR   InterPro; IPR028945; Get1.
DR   InterPro; IPR029012; Helix_hairpin_bin_sf.
DR   Pfam; PF04420; CHD5; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..222
FT                   /note="Protein GET1"
FT                   /id="PRO_0000388600"
FT   TOPO_DOM        1..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..131
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        132..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        149..222
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   REGION          168..222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          48..75
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        194..210
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   222 AA;  25366 MW;  4536E5BC9354862D CRC64;
     MYITNDEFRV FYVRIVRFSA SSKLSSMKKE LFETRQLMNM TSAQDEFSKW AKLRRRVDKL
     SSQVDEQNKS LASSQFVYSI MFKSFMFVLN SAIPFVLNWY YKRVPMFYLP PGDWFGPMGY
     LFSFPNAPAG AVSSTVWTTV CGRVLALVGE YARELFVKDA YLVAEPPMTT EKSSGDKETT
     SKLSTNKPAA MTGEKFDFGK EVKEADQPQG ILKQRRANKS SD