ID   GET3C_ARATH             Reviewed;         391 AA.
AC   Q5XF80; Q9FF47;
DT   17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=ATPase GET3C {ECO:0000305};
DE            Short=AtGET3C {ECO:0000303|PubMed:28096354};
DE            EC=3.6.-.- {ECO:0000305};
DE   AltName: Full=Guided entry of tail-anchored proteins 3 homolog C {ECO:0000305};
DE   Flags: Precursor;
GN   Name=GET3C {ECO:0000303|PubMed:28096354};
GN   OrderedLocusNames=At5g60730 {ECO:0000312|Araport:AT5G60730};
GN   ORFNames=MUP24.15 {ECO:0000312|EMBL:BAB09846.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA   Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA   Miyajima N., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT   features of the 1.6 Mb regions covered by twenty physically assigned P1
RT   clones.";
RL   DNA Res. 4:215-230(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT   "Aradidopsis ORF clones.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX   PubMed=28096354; DOI=10.1073/pnas.1619525114;
RA   Xing S., Mehlhorn D.G., Wallmeroth N., Asseck L.Y., Kar R., Voss A.,
RA   Denninger P., Schmidt V.A., Schwarzlaender M., Stierhof Y.D., Grossmann G.,
RA   Grefen C.;
RT   "Loss of GET pathway orthologs in Arabidopsis thaliana causes root hair
RT   growth defects and affects SNARE abundance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 114:E1544-E1553(2017).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000269|PubMed:28096354}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC       conditions. {ECO:0000269|PubMed:28096354}.
CC   -!- SIMILARITY: Belongs to the arsA ATPase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB09846.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB005246; BAB09846.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED97371.1; -; Genomic_DNA.
DR   EMBL; BT015736; AAU84673.1; -; mRNA.
DR   EMBL; BT020179; AAV43781.1; -; mRNA.
DR   RefSeq; NP_200881.2; NM_125466.4.
DR   AlphaFoldDB; Q5XF80; -.
DR   SMR; Q5XF80; -.
DR   STRING; 3702.AT5G60730.1; -.
DR   SwissPalm; Q5XF80; -.
DR   PaxDb; Q5XF80; -.
DR   PRIDE; Q5XF80; -.
DR   ProteomicsDB; 191406; -.
DR   EnsemblPlants; AT5G60730.1; AT5G60730.1; AT5G60730.
DR   GeneID; 836194; -.
DR   Gramene; AT5G60730.1; AT5G60730.1; AT5G60730.
DR   KEGG; ath:AT5G60730; -.
DR   Araport; AT5G60730; -.
DR   TAIR; locus:2175816; AT5G60730.
DR   eggNOG; KOG2825; Eukaryota.
DR   HOGENOM; CLU_040761_2_1_1; -.
DR   InParanoid; Q5XF80; -.
DR   OMA; QFMEAPE; -.
DR   OrthoDB; 992208at2759; -.
DR   PhylomeDB; Q5XF80; -.
DR   PRO; PR:Q5XF80; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q5XF80; baseline and differential.
DR   GO; GO:0043529; C:GET complex; IBA:GO_Central.
DR   GO; GO:0005759; C:mitochondrial matrix; IDA:TAIR.
DR   GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR   GO; GO:0009536; C:plastid; HDA:TAIR.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0006620; P:post-translational protein targeting to endoplasmic reticulum membrane; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR025723; Anion-transp_ATPase-like_dom.
DR   InterPro; IPR016300; ATPase_ArsA/GET3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10803; PTHR10803; 1.
DR   Pfam; PF02374; ArsA_ATPase; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00345; GET3_arsA_TRC40; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Hydrolase; Mitochondrion; Nucleotide-binding;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..50
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           51..391
FT                   /note="ATPase GET3C"
FT                   /id="PRO_0000449810"
FT   ACT_SITE        106
FT                   /evidence="ECO:0000250|UniProtKB:Q949M9"
FT   BINDING         77..84
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:Q949M9"
FT   BINDING         328
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:Q949M9"
SQ   SEQUENCE   391 AA;  42940 MW;  60083159F0E6AF6F CRC64;
     MAALLLLNRV SRSTSSISLH RVAGTLGFNS FNAQIHGDRI SGTLFRVRSL ATLAEGASHF
     NEMVSVNQRK YYLLGGKGGV GKTSCAASLA VKFASHGHPT IVVSTDPAHS LSDSFSQDLS
     GGVLKPVQGV DSPLLALEIT PEIMKDEIKR QTGDKSVKNM MDSMGLGMFA GELGDLNLED
     MLNAASPGID EIAAISKVLQ FMEAPEYSRF TRIVFDTAPT GHTLRLLSLP DFYDSSISKI
     TKLKKKITAA ASAFKLVFGK KEIQQKELPN ELDQLKERME KVRNVFRDVD TTEFVIVTIP
     TVMAINESSR LHASLRKENV PVHRLIVNQL LPQSESDCKF CSIRRKEQTR VLGLIQNDTE
     LSGLKLIQSP LLDAEIRGVP ALKFMGDLIW K