ID   GET4_CHICK              Reviewed;         312 AA.
AC   Q5ZKG8;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Golgi to ER traffic protein 4 homolog;
GN   Name=GET4; ORFNames=RCJMB04_10o20;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: As part of a cytosolic protein quality control complex, the
CC       BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-
CC       containing proteins in a soluble state and participates in their proper
CC       delivery to the endoplasmic reticulum or alternatively can promote
CC       their sorting to the proteasome where they undergo degradation. The
CC       BAG6/BAT3 complex is involved in the post-translational delivery of
CC       tail-anchored/type II transmembrane proteins to the endoplasmic
CC       reticulum membrane. Recruited to ribosomes, it interacts with the
CC       transmembrane region of newly synthesized tail-anchored proteins and
CC       together with SGTA and ASNA1 mediates their delivery to the endoplasmic
CC       reticulum. Client proteins that cannot be properly delivered to the
CC       endoplasmic reticulum are ubiquitinated and sorted to the proteasome.
CC       Similarly, the BAG6/BAT3 complex also functions as a sorting platform
CC       for proteins of the secretory pathway that are mislocalized to the
CC       cytosol either delivering them to the proteasome for degradation or to
CC       the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in
CC       the endoplasmic reticulum-associated degradation (ERAD), a quality
CC       control mechanism that eliminates unwanted proteins of the endoplasmic
CC       reticulum through their retrotranslocation to the cytosol and their
CC       targeting to the proteasome. It maintains these retrotranslocated
CC       proteins in an unfolded yet soluble state condition in the cytosol to
CC       ensure their proper delivery to the proteasome.
CC       {ECO:0000250|UniProtKB:Q7L5D6}.
CC   -!- SUBUNIT: Component of the BAG6/BAT3 complex.
CC       {ECO:0000250|UniProtKB:Q7L5D6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q7L5D6}.
CC   -!- SIMILARITY: Belongs to the GET4 family. {ECO:0000305}.
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DR   EMBL; AJ720116; CAG31775.1; -; mRNA.
DR   RefSeq; NP_001006159.1; NM_001006159.2.
DR   AlphaFoldDB; Q5ZKG8; -.
DR   SMR; Q5ZKG8; -.
DR   STRING; 9031.ENSGALP00000006013; -.
DR   PaxDb; Q5ZKG8; -.
DR   GeneID; 416450; -.
DR   KEGG; gga:416450; -.
DR   CTD; 51608; -.
DR   VEuPathDB; HostDB:geneid_416450; -.
DR   eggNOG; KOG3024; Eukaryota.
DR   HOGENOM; CLU_046061_2_0_1; -.
DR   InParanoid; Q5ZKG8; -.
DR   OrthoDB; 1030907at2759; -.
DR   PhylomeDB; Q5ZKG8; -.
DR   PRO; PR:Q5ZKG8; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0071818; C:BAT3 complex; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0045048; P:protein insertion into ER membrane; IBA:GO_Central.
DR   GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR007317; GET4.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12875; PTHR12875; 1.
DR   Pfam; PF04190; GET4; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Transport.
FT   CHAIN           1..312
FT                   /note="Golgi to ER traffic protein 4 homolog"
FT                   /id="PRO_0000403720"
FT   REGION          290..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        294..312
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   312 AA;  34648 MW;  8A31B94309E9306E CRC64;
     MAAAIMAAEQ EAAKGGGRNR GGVQRVEGKL RASVEKGDYY EAHQMYRTLF FRYMSQGKYV
     EARELMYSGA LLFFSHNQQN SAADLSMLVL ESLEKSDAKV TDDLLENLAK LFSLMDPNSP
     ERVAFVSRAL KWSSGGSGKL GHPKLHQLLA ITLWKDGEGC ANMLVEYSSS RGYRSEVDMF
     VAQAVLQFLC LKNKTSASVV FTTYTQKHPS IEKGPPFVQP LLNFIWFLLL AVDGGKLTVF
     TVLCEQYQPS LKRDPMYNEY LDRIGQLFFG VPPKQTSSYG GLLGNLLNSL MGTGEDDDTE
     DGQEDSSPIE LD