ID   GET4_ORYLA              Reviewed;         323 AA.
AC   A1Z3X3;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Golgi to ER traffic protein 4 homolog;
DE   AltName: Full=Conserved edge expressed protein;
GN   Name=get4; Synonyms=cee;
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=18249086; DOI=10.1016/j.ygeno.2007.10.017;
RA   Fernandes J.M.O., Macqueen D.J., Lee H.-T., Johnston I.A.;
RT   "Genomic, evolutionary, and expression analyses of cee, an ancient gene
RT   involved in normal growth and development.";
RL   Genomics 91:315-325(2008).
CC   -!- FUNCTION: As part of a cytosolic protein quality control complex, the
CC       bag6/bat3 complex, maintains misfolded and hydrophobic patches-
CC       containing proteins in a soluble state and participates in their proper
CC       delivery to the endoplasmic reticulum or alternatively can promote
CC       their sorting to the proteasome where they undergo degradation. The
CC       bag6/bat3 complex is involved in the post-translational delivery of
CC       tail-anchored/type II transmembrane proteins to the endoplasmic
CC       reticulum membrane. Similarly, the bag6/bat3 complex also functions as
CC       a sorting platform for proteins of the secretory pathway that are
CC       mislocalized to the cytosol either delivering them to the proteasome
CC       for degradation or to the endoplasmic reticulum. The bag6/bat3 complex
CC       also plays a role in the endoplasmic reticulum-associated degradation
CC       (ERAD), a quality control mechanism that eliminates unwanted proteins
CC       of the endoplasmic reticulum through their retrotranslocation to the
CC       cytosol and their targeting to the proteasome. It maintains these
CC       retrotranslocated proteins in an unfolded yet soluble state condition
CC       in the cytosol to ensure their proper delivery to the proteasome.
CC       {ECO:0000250|UniProtKB:Q7L5D6}.
CC   -!- SUBUNIT: Component of the bag6/bat3 complex.
CC       {ECO:0000250|UniProtKB:Q7L5D6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q7L5D6}.
CC   -!- SIMILARITY: Belongs to the GET4 family. {ECO:0000305}.
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DR   EMBL; EF177382; ABM53480.1; -; mRNA.
DR   RefSeq; NP_001098381.1; NM_001104911.1.
DR   AlphaFoldDB; A1Z3X3; -.
DR   SMR; A1Z3X3; -.
DR   STRING; 8090.ENSORLP00000025242; -.
DR   GeneID; 100125476; -.
DR   KEGG; ola:100125476; -.
DR   CTD; 51608; -.
DR   eggNOG; KOG3024; Eukaryota.
DR   InParanoid; A1Z3X3; -.
DR   OrthoDB; 1030907at2759; -.
DR   Proteomes; UP000001038; Unplaced.
DR   Proteomes; UP000265180; Chromosome 9.
DR   Proteomes; UP000265200; Chromosome 9.
DR   GO; GO:0071818; C:BAT3 complex; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0045048; P:protein insertion into ER membrane; IBA:GO_Central.
DR   GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR007317; GET4.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12875; PTHR12875; 1.
DR   Pfam; PF04190; GET4; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Transport.
FT   CHAIN           1..323
FT                   /note="Golgi to ER traffic protein 4 homolog"
FT                   /id="PRO_0000403722"
FT   REGION          303..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..323
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   323 AA;  36572 MW;  A0EE395C2E9BFF62 CRC64;
     MSDPESLRCS SVRNRGGVQR VEGKLRASVE RGDYYEAHQM YRTLFFRYMS QAKHAEAREL
     MYRGALLFFS HNQQNSAADL SMLVLEVLEK SDAKVEDEIL EHLAKLFSLM DQNSPERAAF
     VSRALKWSTG GSSKLGHPKL HQLLALTLWK EQNYSESRYH FLHSSDGEGC AQMLVEYWAS
     RGYRNEVDLF VAQAVLQFLC LKNKSSASVV FSTYTEKHPS IQKGPPFVQP LLNFIWFLLL
     AVDGGKLTVF TVLCEQYQPS LKRDPMYNEY LDRIGQLFFG VPPKQSPSYG GLLGNLLNSL
     MGSGEDDDGV EEAQEDSSPI ELD