GET4_SALSA
ID GET4_SALSA Reviewed; 322 AA.
AC A0MT11;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 25-MAY-2022, entry version 36.
DE RecName: Full=Golgi to ER traffic protein 4 homolog;
DE AltName: Full=Conserved edge expressed protein;
GN Name=get4; Synonyms=cee;
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=18249086; DOI=10.1016/j.ygeno.2007.10.017;
RA Fernandes J.M.O., Macqueen D.J., Lee H.-T., Johnston I.A.;
RT "Genomic, evolutionary, and expression analyses of cee, an ancient gene
RT involved in normal growth and development.";
RL Genomics 91:315-325(2008).
CC -!- FUNCTION: As part of a cytosolic protein quality control complex, the
CC bag6/bat3 complex, maintains misfolded and hydrophobic patches-
CC containing proteins in a soluble state and participates in their proper
CC delivery to the endoplasmic reticulum or alternatively can promote
CC their sorting to the proteasome where they undergo degradation. The
CC bag6/bat3 complex is involved in the post-translational delivery of
CC tail-anchored/type II transmembrane proteins to the endoplasmic
CC reticulum membrane. Similarly, the bag6/bat3 complex also functions as
CC a sorting platform for proteins of the secretory pathway that are
CC mislocalized to the cytosol either delivering them to the proteasome
CC for degradation or to the endoplasmic reticulum. The bag6/bat3 complex
CC also plays a role in the endoplasmic reticulum-associated degradation
CC (ERAD), a quality control mechanism that eliminates unwanted proteins
CC of the endoplasmic reticulum through their retrotranslocation to the
CC cytosol and their targeting to the proteasome. It maintains these
CC retrotranslocated proteins in an unfolded yet soluble state condition
CC in the cytosol to ensure their proper delivery to the proteasome.
CC {ECO:0000250|UniProtKB:Q7L5D6}.
CC -!- SUBUNIT: Component of the bag6/bat3 complex.
CC {ECO:0000250|UniProtKB:Q7L5D6}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q7L5D6}.
CC -!- SIMILARITY: Belongs to the GET4 family. {ECO:0000305}.
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DR EMBL; EF036472; ABK35126.2; -; mRNA.
DR RefSeq; NP_001117086.1; NM_001123614.1.
DR AlphaFoldDB; A0MT11; -.
DR SMR; A0MT11; -.
DR STRING; 8030.ENSSSAP00000053126; -.
DR GeneID; 100136505; -.
DR KEGG; sasa:100136505; -.
DR CTD; 51608; -.
DR OMA; QIGEMYF; -.
DR OrthoDB; 1030907at2759; -.
DR Proteomes; UP000087266; Chromosome ssa19.
DR GO; GO:0071818; C:BAT3 complex; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR007317; GET4.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12875; PTHR12875; 1.
DR Pfam; PF04190; GET4; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome; Transport.
FT CHAIN 1..322
FT /note="Golgi to ER traffic protein 4 homolog"
FT /id="PRO_0000403724"
FT REGION 303..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 322 AA; 36305 MW; 7FF75878B4F74E61 CRC64;
MSEQEALKCS SARNRGGTQR VEGKLRASVE KGDYYEAHQM YRTLFFRYIS QAKHTDAREL
MYNGAQLFFS YNQLNSAADL SMLVLESLEK SEAKVEDEDL EHLAKLFSLM DPNSPERVAF
VSRALKWSTG GSGKLGAPKL HQLLAVTLWK EQNYSESRYH FLHSSDGEGC AQMLVEYSAQ
RGFRSEVDMF VAQAVLQFLC LKNKNSASVV FSTYTQKHPS IEKDPPFVQP LLNFIWFLLL
AVDGGKLTVF TVLCEQYQPS LKRDPMYNEY LDRIGQLFFG VPPKQSSSYG GLLGNLLNSL
MGSGEDEEGE EAQEHGSPIE LD
