ID   GET4_TAEGU              Reviewed;         328 AA.
AC   B5KFI0;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Golgi to ER traffic protein 4 homolog;
GN   Name=GET4;
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC   Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=17018643; DOI=10.1073/pnas.0607098103;
RA   Wada K., Howard J.T., McConnell P., Whitney O., Lints T., Rivas M.V.,
RA   Horita H., Patterson M.A., White S.A., Scharff C., Haesler S., Zhao S.,
RA   Sakaguchi H., Hagiwara M., Shiraki T., Hirozane-Kishikawa T., Skene P.,
RA   Hayashizaki Y., Carninci P., Jarvis E.D.;
RT   "A molecular neuroethological approach for identifying and characterizing a
RT   cascade of behaviorally regulated genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15212-15217(2006).
CC   -!- FUNCTION: As part of a cytosolic protein quality control complex, the
CC       BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-
CC       containing proteins in a soluble state and participates in their proper
CC       delivery to the endoplasmic reticulum or alternatively can promote
CC       their sorting to the proteasome where they undergo degradation. The
CC       BAG6/BAT3 complex is involved in the post-translational delivery of
CC       tail-anchored/type II transmembrane proteins to the endoplasmic
CC       reticulum membrane. Recruited to ribosomes, it interacts with the
CC       transmembrane region of newly synthesized tail-anchored proteins and
CC       together with SGTA and ASNA1 mediates their delivery to the endoplasmic
CC       reticulum. Client proteins that cannot be properly delivered to the
CC       endoplasmic reticulum are ubiquitinated and sorted to the proteasome.
CC       Similarly, the BAG6/BAT3 complex also functions as a sorting platform
CC       for proteins of the secretory pathway that are mislocalized to the
CC       cytosol either delivering them to the proteasome for degradation or to
CC       the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in
CC       the endoplasmic reticulum-associated degradation (ERAD), a quality
CC       control mechanism that eliminates unwanted proteins of the endoplasmic
CC       reticulum through their retrotranslocation to the cytosol and their
CC       targeting to the proteasome. It maintains these retrotranslocated
CC       proteins in an unfolded yet soluble state condition in the cytosol to
CC       ensure their proper delivery to the proteasome.
CC       {ECO:0000250|UniProtKB:Q7L5D6}.
CC   -!- SUBUNIT: Component of the BAG6/BAT3 complex.
CC       {ECO:0000250|UniProtKB:Q7L5D6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q7L5D6}.
CC   -!- SIMILARITY: Belongs to the GET4 family. {ECO:0000305}.
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DR   EMBL; EF191709; ACH46328.1; -; mRNA.
DR   RefSeq; NP_001232308.1; NM_001245379.1.
DR   AlphaFoldDB; B5KFI0; -.
DR   SMR; B5KFI0; -.
DR   STRING; 59729.ENSTGUP00000008686; -.
DR   Ensembl; ENSTGUT00000008778; ENSTGUP00000008686; ENSTGUG00000008424.
DR   GeneID; 100190551; -.
DR   KEGG; tgu:100190551; -.
DR   CTD; 51608; -.
DR   GeneTree; ENSGT00390000015750; -.
DR   InParanoid; B5KFI0; -.
DR   OrthoDB; 1030907at2759; -.
DR   Proteomes; UP000007754; Chromosome 14.
DR   GO; GO:0071818; C:BAT3 complex; ISS:UniProtKB.
DR   GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0051087; F:chaperone binding; IEA:Ensembl.
DR   GO; GO:0051220; P:cytoplasmic sequestering of protein; IEA:Ensembl.
DR   GO; GO:1904378; P:maintenance of unfolded protein involved in ERAD pathway; IEA:Ensembl.
DR   GO; GO:0006620; P:post-translational protein targeting to endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; ISS:UniProtKB.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR007317; GET4.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12875; PTHR12875; 1.
DR   Pfam; PF04190; GET4; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Transport.
FT   CHAIN           1..328
FT                   /note="Golgi to ER traffic protein 4 homolog"
FT                   /id="PRO_0000403721"
FT   REGION          306..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        310..328
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   328 AA;  36529 MW;  41E382007BEFD1EE CRC64;
     MAAAIMAAEQ EAAKGGGGRN RGGVQRVEGK LRASVEKGDY YEAHQMYRTL FFRYMSQGKH
     AEARELMYSG ALLFFSHNQQ NSAADLSMLV LESLEKSDAK VAEDLLENLA KLFSLMDPNS
     PERVAFVSRA LKWSSGGSGK LGHPKLHQLL AITLWKEQNY SESRYHFLHS TDGEGCANML
     VEYSSSRGYR SEVDMFVAQA VLQFLCLKNK TSASVVFTTY TQKHPSIEKG PPFVQPLLNF
     IWFLLLAVDG GKLTVFTVLC EQYQPSLKRD PMYNEYLDRI GQLFFGVPPK QTSSYGGLLG
     NLLNSLMGTG EDDDTEEGQE DSSPIELD