ID   GET4_XENTR              Reviewed;         325 AA.
AC   A4QNE0;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Golgi to ER traffic protein 4 homolog;
GN   Name=get4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As part of a cytosolic protein quality control complex, the
CC       bag6/bat3 complex, maintains misfolded and hydrophobic patches-
CC       containing proteins in a soluble state and participates in their proper
CC       delivery to the endoplasmic reticulum or alternatively can promote
CC       their sorting to the proteasome where they undergo degradation. The
CC       bag6/bat3 complex is involved in the post-translational delivery of
CC       tail-anchored/type II transmembrane proteins to the endoplasmic
CC       reticulum membrane. Similarly, the bag6/bat3 complex also functions as
CC       a sorting platform for proteins of the secretory pathway that are
CC       mislocalized to the cytosol either delivering them to the proteasome
CC       for degradation or to the endoplasmic reticulum. The bag6/bat3 complex
CC       also plays a role in the endoplasmic reticulum-associated degradation
CC       (ERAD), a quality control mechanism that eliminates unwanted proteins
CC       of the endoplasmic reticulum through their retrotranslocation to the
CC       cytosol and their targeting to the proteasome. It maintains these
CC       retrotranslocated proteins in an unfolded yet soluble state condition
CC       in the cytosol to ensure their proper delivery to the proteasome.
CC       {ECO:0000250|UniProtKB:Q7L5D6}.
CC   -!- SUBUNIT: Component of the bag6/bat3 complex.
CC       {ECO:0000250|UniProtKB:Q7L5D6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q7L5D6}.
CC   -!- SIMILARITY: Belongs to the GET4 family. {ECO:0000305}.
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DR   EMBL; BC135489; AAI35490.1; -; mRNA.
DR   RefSeq; NP_001016708.1; NM_001016708.2.
DR   AlphaFoldDB; A4QNE0; -.
DR   SMR; A4QNE0; -.
DR   STRING; 8364.ENSXETP00000046760; -.
DR   PaxDb; A4QNE0; -.
DR   DNASU; 549462; -.
DR   Ensembl; ENSXETT00000046760; ENSXETP00000046760; ENSXETG00000021638.
DR   GeneID; 549462; -.
DR   KEGG; xtr:549462; -.
DR   CTD; 51608; -.
DR   Xenbase; XB-GENE-975153; get4.
DR   eggNOG; KOG3024; Eukaryota.
DR   HOGENOM; CLU_046061_2_0_1; -.
DR   InParanoid; A4QNE0; -.
DR   OMA; QIGEMYF; -.
DR   OrthoDB; 1030907at2759; -.
DR   PhylomeDB; A4QNE0; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000021638; Expressed in skeletal muscle tissue and 13 other tissues.
DR   ExpressionAtlas; A4QNE0; differential.
DR   GO; GO:0071818; C:BAT3 complex; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0045048; P:protein insertion into ER membrane; IBA:GO_Central.
DR   GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR007317; GET4.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12875; PTHR12875; 1.
DR   Pfam; PF04190; GET4; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Transport.
FT   CHAIN           1..325
FT                   /note="Golgi to ER traffic protein 4 homolog"
FT                   /id="PRO_0000403727"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          306..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..325
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   325 AA;  36643 MW;  21B8E7EDCD65C026 CRC64;
     MAAAMAEQDG SKGSARNRGG VQRVEGKLRA SVEKGDYYEA HQMYRTLFFR YMSQSKHIEA
     RELMYSGALL FFSHSQQNSA ADLSMLVLES LEKHEVKVTE ELLENLAKLF SLMDPNSPER
     VAFVSRALKW SSGGSGKFGH PKLHQFLAIT LWKEQNYYES RYHFLHSSDG EGCANMLVEY
     SSTRGYRSEV DMFVAQAVLQ FLCLKNKTSA SVVFTTYTQK HPSIERGPPF VQPLLNFIWF
     LLLAVEGGKL TVFTVLCEQY QPSLKRDPMY NEYLDRIGQL FFGVPPKQSS SYGGLLGNLL
     NSLMGSGEDD DVEDGQEDSS PIELD