ID   GFAP_CARAU              Reviewed;         365 AA.
AC   P48677;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Glial fibrillary acidic protein;
DE            Short=GFAP;
DE   Flags: Fragment;
GN   Name=gfap;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RA   Glasgow E., Schechter N.;
RT   "Nucleotide sequence of a GFAP-like intermediate filament cDNA from
RT   Goldfish retina.";
RL   Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA49166.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L23876; AAA49166.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; P48677; -.
DR   SMR; P48677; -.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR027701; GFAP.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR45652:SF9; PTHR45652:SF9; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Reference proteome.
FT   CHAIN           <1..365
FT                   /note="Glial fibrillary acidic protein"
FT                   /id="PRO_0000063808"
FT   DOMAIN          2..310
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          <1..5
FT                   /note="Head"
FT   REGION          6..37
FT                   /note="Coil 1A"
FT   REGION          38..48
FT                   /note="Linker 1"
FT   REGION          49..147
FT                   /note="Coil 1B"
FT   REGION          148..163
FT                   /note="Linker 12"
FT   REGION          164..185
FT                   /note="Coil 2A"
FT   REGION          186..189
FT                   /note="Linker 2"
FT   REGION          190..310
FT                   /note="Coil 2B"
FT   REGION          311..365
FT                   /note="Tail"
FT   NON_TER         1
SQ   SEQUENCE   365 AA;  42605 MW;  47B523C78D387E26 CRC64;
     REVDRVMGLN DRFASYIEKV RFLEQQNKML VAELNQLRGK EPSRLGDIYQ EELRELRRQV
     DGLNAGKARL EIERDNLASD LATLKQRLQE ENALRQEAEN NLNTFRQDVD EAALNRVQLE
     RKIDALQDEI SFLRKVHEEE MRQLQEQLIA QQVHVDLDVS KPDLTTALKE IRAQFEAMAT
     SNMQETEEWY RSKFADLTDA AGRNAEALRQ AKQEANEYRR QIQGLTCDLE SLRGSNESLE
     RQLREMEERF AIETAGYQDT VARLEDEIQM LKEEMARHLQ EYQDLLNVKL ALDIEIATYR
     KLLEGEESRI TVPVQNFTNL QFRDTSLDTK LTPEAHVKRS IVVRTVETRD GEIIKESTTE
     RKDLP