GFAP_DANRE
ID GFAP_DANRE Reviewed; 444 AA.
AC Q58EE9; A2VCX6; Q5YLV6; Q6NUV9; Q6TH89; Q7T2N9; Q9PW34;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Glial fibrillary acidic protein;
DE Short=GFAP;
GN Name=gfap;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA / MRNA], SUBUNIT, AND SUBCELLULAR
RP LOCATION.
RX PubMed=12801639; DOI=10.1016/s0378-1119(03)00526-2;
RA Nielsen A.L., Joergensen A.L.;
RT "Structural and functional characterization of the zebrafish gene for glial
RT fibrillary acidic protein, GFAP.";
RL Gene 310:123-132(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Emelyanov A., Dheen T., Anilkumar M., Korzh V.;
RT "Expression analysis of GFAP-related gene in zebrafish embryogenesis.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 263-377.
RA Clark S., Dale E., Giordano S.;
RT "Nucleotide sequence of a GFAP-like cDNA from zebrafish embryos.";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Forms homodimers. {ECO:0000269|PubMed:12801639}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:12801639}. Note=Associated with intermediate
CC filaments.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; AY151283; AAN87836.1; -; mRNA.
DR EMBL; AY151284; AAN87837.1; -; mRNA.
DR EMBL; AY151290; AAN39562.1; -; Genomic_DNA.
DR EMBL; AY151288; AAN39562.1; JOINED; Genomic_DNA.
DR EMBL; AY151289; AAN39562.1; JOINED; Genomic_DNA.
DR EMBL; AY397679; AAR19286.1; -; Transcribed_RNA.
DR EMBL; BC068410; AAH68410.1; -; mRNA.
DR EMBL; BC091942; AAH91942.1; -; mRNA.
DR EMBL; BC128803; AAI28804.1; -; mRNA.
DR EMBL; AF174393; AAD49749.1; -; mRNA.
DR RefSeq; NP_571448.2; NM_131373.2.
DR AlphaFoldDB; Q58EE9; -.
DR SMR; Q58EE9; -.
DR STRING; 7955.ENSDARP00000029607; -.
DR PaxDb; Q58EE9; -.
DR PRIDE; Q58EE9; -.
DR GeneID; 30646; -.
DR KEGG; dre:30646; -.
DR CTD; 2670; -.
DR ZFIN; ZDB-GENE-990914-3; gfap.
DR eggNOG; ENOG502RKU6; Eukaryota.
DR InParanoid; Q58EE9; -.
DR PhylomeDB; Q58EE9; -.
DR PRO; PR:Q58EE9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IDA:ZFIN.
DR GO; GO:0005882; C:intermediate filament; IBA:GO_Central.
DR GO; GO:0045098; C:type III intermediate filament; IDA:ZFIN.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:1904714; P:regulation of chaperone-mediated autophagy; IBA:GO_Central.
DR InterPro; IPR027701; GFAP.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652:SF9; PTHR45652:SF9; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Intermediate filament;
KW Reference proteome.
FT CHAIN 1..444
FT /note="Glial fibrillary acidic protein"
FT /id="PRO_0000291620"
FT DOMAIN 81..389
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..84
FT /note="Head"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..116
FT /note="Coil 1A"
FT REGION 117..127
FT /note="Linker 1"
FT REGION 128..226
FT /note="Coil 1B"
FT REGION 227..242
FT /note="Linker 12"
FT REGION 243..264
FT /note="Coil 2A"
FT REGION 265..268
FT /note="Linker 2"
FT REGION 269..389
FT /note="Coil 2B"
FT REGION 390..444
FT /note="Tail"
FT CONFLICT 77..85
FT /note="Missing (in Ref. 1; AAN39562)"
FT /evidence="ECO:0000305"
FT CONFLICT 252
FT /note="A -> S (in Ref. 1; AAN39562 and 2; AAR19286)"
FT /evidence="ECO:0000305"
FT CONFLICT 259
FT /note="N -> T (in Ref. 1; AAN87837/AAN87836)"
FT /evidence="ECO:0000305"
FT CONFLICT 263
FT /note="Q -> H (in Ref. 4; AAD49749)"
FT /evidence="ECO:0000305"
FT CONFLICT 314
FT /note="S -> Y (in Ref. 2; AAR19286)"
FT /evidence="ECO:0000305"
FT CONFLICT 321
FT /note="Q -> R (in Ref. 4; AAD49749)"
FT /evidence="ECO:0000305"
FT CONFLICT 323
FT /note="R -> K (in Ref. 3; AAH91942)"
FT /evidence="ECO:0000305"
FT CONFLICT 323
FT /note="R -> T (in Ref. 2; AAR19286)"
FT /evidence="ECO:0000305"
FT CONFLICT 335
FT /note="G -> A (in Ref. 3; AAI28804)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 444 AA; 51249 MW; 9435B408BDE47AED CRC64;
MESQRSFSSY RKRFGTPGGS PSVGVTSRHS TGRLSLHSSP RHLTSSPLTL STSRLSLGGE
RLDFSADSLL KAQYRETRTN EKVEMMGLND RFASYIEKVR FLEQQNKMLV AELNQLRGKE
PSRLGDIYQE ELRELRRQVD GLNAGKARLE IERDNLASDL GTLKQRLQDE TALRQEAENN
LNTFRQDVDE AALNRVQLER KIEALQDEIN FLKKVHEEEM RELHEQLMAQ QVHVDLDVSK
PDLTAALKEI RAQFEAMANS NMQETEEWYR SKFADLTDAA NRNGEALRQA KQEANDYRRQ
IQGLTCDLES LRGSNESLER QLREMEERFA IETAGYQDTV ARLEDEIQML KEEMARHLQE
YQDLLNVKLA LDIEIATYRK LLEGEESRIT VPVQNFTNLQ FRDTSMDTKL TPEAHVKRSI
VVRTVETRDG EIIKESTTER KDLP
