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GFAP_DANRE
ID   GFAP_DANRE              Reviewed;         444 AA.
AC   Q58EE9; A2VCX6; Q5YLV6; Q6NUV9; Q6TH89; Q7T2N9; Q9PW34;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Glial fibrillary acidic protein;
DE            Short=GFAP;
GN   Name=gfap;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA / MRNA], SUBUNIT, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=12801639; DOI=10.1016/s0378-1119(03)00526-2;
RA   Nielsen A.L., Joergensen A.L.;
RT   "Structural and functional characterization of the zebrafish gene for glial
RT   fibrillary acidic protein, GFAP.";
RL   Gene 310:123-132(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Emelyanov A., Dheen T., Anilkumar M., Korzh V.;
RT   "Expression analysis of GFAP-related gene in zebrafish embryogenesis.";
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 263-377.
RA   Clark S., Dale E., Giordano S.;
RT   "Nucleotide sequence of a GFAP-like cDNA from zebrafish embryos.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Forms homodimers. {ECO:0000269|PubMed:12801639}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000269|PubMed:12801639}. Note=Associated with intermediate
CC       filaments.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; AY151283; AAN87836.1; -; mRNA.
DR   EMBL; AY151284; AAN87837.1; -; mRNA.
DR   EMBL; AY151290; AAN39562.1; -; Genomic_DNA.
DR   EMBL; AY151288; AAN39562.1; JOINED; Genomic_DNA.
DR   EMBL; AY151289; AAN39562.1; JOINED; Genomic_DNA.
DR   EMBL; AY397679; AAR19286.1; -; Transcribed_RNA.
DR   EMBL; BC068410; AAH68410.1; -; mRNA.
DR   EMBL; BC091942; AAH91942.1; -; mRNA.
DR   EMBL; BC128803; AAI28804.1; -; mRNA.
DR   EMBL; AF174393; AAD49749.1; -; mRNA.
DR   RefSeq; NP_571448.2; NM_131373.2.
DR   AlphaFoldDB; Q58EE9; -.
DR   SMR; Q58EE9; -.
DR   STRING; 7955.ENSDARP00000029607; -.
DR   PaxDb; Q58EE9; -.
DR   PRIDE; Q58EE9; -.
DR   GeneID; 30646; -.
DR   KEGG; dre:30646; -.
DR   CTD; 2670; -.
DR   ZFIN; ZDB-GENE-990914-3; gfap.
DR   eggNOG; ENOG502RKU6; Eukaryota.
DR   InParanoid; Q58EE9; -.
DR   PhylomeDB; Q58EE9; -.
DR   PRO; PR:Q58EE9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IDA:ZFIN.
DR   GO; GO:0005882; C:intermediate filament; IBA:GO_Central.
DR   GO; GO:0045098; C:type III intermediate filament; IDA:ZFIN.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR   GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR   GO; GO:1904714; P:regulation of chaperone-mediated autophagy; IBA:GO_Central.
DR   InterPro; IPR027701; GFAP.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR006821; Intermed_filament_DNA-bd.
DR   PANTHER; PTHR45652:SF9; PTHR45652:SF9; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF04732; Filament_head; 1.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Intermediate filament;
KW   Reference proteome.
FT   CHAIN           1..444
FT                   /note="Glial fibrillary acidic protein"
FT                   /id="PRO_0000291620"
FT   DOMAIN          81..389
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..84
FT                   /note="Head"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          85..116
FT                   /note="Coil 1A"
FT   REGION          117..127
FT                   /note="Linker 1"
FT   REGION          128..226
FT                   /note="Coil 1B"
FT   REGION          227..242
FT                   /note="Linker 12"
FT   REGION          243..264
FT                   /note="Coil 2A"
FT   REGION          265..268
FT                   /note="Linker 2"
FT   REGION          269..389
FT                   /note="Coil 2B"
FT   REGION          390..444
FT                   /note="Tail"
FT   CONFLICT        77..85
FT                   /note="Missing (in Ref. 1; AAN39562)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        252
FT                   /note="A -> S (in Ref. 1; AAN39562 and 2; AAR19286)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        259
FT                   /note="N -> T (in Ref. 1; AAN87837/AAN87836)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        263
FT                   /note="Q -> H (in Ref. 4; AAD49749)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        314
FT                   /note="S -> Y (in Ref. 2; AAR19286)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        321
FT                   /note="Q -> R (in Ref. 4; AAD49749)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        323
FT                   /note="R -> K (in Ref. 3; AAH91942)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        323
FT                   /note="R -> T (in Ref. 2; AAR19286)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        335
FT                   /note="G -> A (in Ref. 3; AAI28804)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   444 AA;  51249 MW;  9435B408BDE47AED CRC64;
     MESQRSFSSY RKRFGTPGGS PSVGVTSRHS TGRLSLHSSP RHLTSSPLTL STSRLSLGGE
     RLDFSADSLL KAQYRETRTN EKVEMMGLND RFASYIEKVR FLEQQNKMLV AELNQLRGKE
     PSRLGDIYQE ELRELRRQVD GLNAGKARLE IERDNLASDL GTLKQRLQDE TALRQEAENN
     LNTFRQDVDE AALNRVQLER KIEALQDEIN FLKKVHEEEM RELHEQLMAQ QVHVDLDVSK
     PDLTAALKEI RAQFEAMANS NMQETEEWYR SKFADLTDAA NRNGEALRQA KQEANDYRRQ
     IQGLTCDLES LRGSNESLER QLREMEERFA IETAGYQDTV ARLEDEIQML KEEMARHLQE
     YQDLLNVKLA LDIEIATYRK LLEGEESRIT VPVQNFTNLQ FRDTSMDTKL TPEAHVKRSI
     VVRTVETRDG EIIKESTTER KDLP
 
 
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