GFAP_PONAB
ID GFAP_PONAB Reviewed; 432 AA.
AC Q5RA72;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Glial fibrillary acidic protein;
DE Short=GFAP;
GN Name=GFAP;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GFAP, a class-III intermediate filament, is a cell-specific
CC marker that, during the development of the central nervous system,
CC distinguishes astrocytes from other glial cells. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SYNM. {ECO:0000250|UniProtKB:P03995}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P14136}.
CC Note=Associated with intermediate filaments.
CC {ECO:0000250|UniProtKB:P14136}.
CC -!- PTM: Phosphorylated by PKN1. {ECO:0000250|UniProtKB:P14136}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; CR859147; CAH91338.1; -; mRNA.
DR RefSeq; NP_001125791.1; NM_001132319.1.
DR AlphaFoldDB; Q5RA72; -.
DR SMR; Q5RA72; -.
DR STRING; 9601.ENSPPYP00000009349; -.
DR Ensembl; ENSPPYT00000038650; ENSPPYP00000033918; ENSPPYG00000008318.
DR GeneID; 100172719; -.
DR KEGG; pon:100172719; -.
DR CTD; 2670; -.
DR eggNOG; ENOG502RKU6; Eukaryota.
DR GeneTree; ENSGT00940000159539; -.
DR InParanoid; Q5RA72; -.
DR Proteomes; UP000001595; Chromosome 17.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0045109; P:intermediate filament organization; ISS:UniProtKB.
DR InterPro; IPR027701; GFAP.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652:SF9; PTHR45652:SF9; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Citrullination; Coiled coil; Cytoplasm; Intermediate filament; Methylation;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..432
FT /note="Glial fibrillary acidic protein"
FT /id="PRO_0000318190"
FT DOMAIN 69..377
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..72
FT /note="Head"
FT REGION 73..104
FT /note="Coil 1A"
FT REGION 105..115
FT /note="Linker 1"
FT REGION 116..214
FT /note="Coil 1B"
FT REGION 215..230
FT /note="Linker 12"
FT REGION 231..252
FT /note="Coil 2A"
FT REGION 253..256
FT /note="Linker 2"
FT REGION 257..377
FT /note="Coil 2B"
FT REGION 378..432
FT /note="Tail"
FT MOD_RES 7
FT /note="Phosphothreonine; by AURKB and ROCK1"
FT /evidence="ECO:0000250|UniProtKB:P14136"
FT MOD_RES 12
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:P03995"
FT MOD_RES 13
FT /note="Phosphoserine; by AURKB and ROCK1"
FT /evidence="ECO:0000250|UniProtKB:P14136"
FT MOD_RES 30
FT /note="Citrulline"
FT /evidence="ECO:0000250"
FT MOD_RES 36
FT /note="Citrulline"
FT /evidence="ECO:0000250"
FT MOD_RES 38
FT /note="Phosphoserine; by AURKB and ROCK1"
FT /evidence="ECO:0000250|UniProtKB:P14136"
FT MOD_RES 82
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P47819"
FT MOD_RES 110
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P47819"
FT MOD_RES 150
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P47819"
FT MOD_RES 270
FT /note="Citrulline"
FT /evidence="ECO:0000250"
FT MOD_RES 323
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P47819"
FT MOD_RES 383
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P47819"
FT MOD_RES 385
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P47819"
FT MOD_RES 406
FT /note="Citrulline"
FT /evidence="ECO:0000250"
FT MOD_RES 416
FT /note="Citrulline"
FT /evidence="ECO:0000250"
SQ SEQUENCE 432 AA; 49872 MW; C5C85D399EDDFCB0 CRC64;
MERRRITSAA RRSYISSGEM MVGGLAPGRR LGPGTRLSLA RMPPPLPTRV DFSLAGALNA
GFKETRASER AEMMELNDRF ASYIEKVRFL EQQNKALAAE LNQLRAKEPT KLADVYQAEL
RELRLRLDQL TANSARLEVE RDNLAQDLGT VRQKLQDETN LRLEAENNLA AYRQEADEAT
LARLDLERKT ESLEEEIRFL RKIHEEEVRE LQEQLARQQV HVELDMAKPD LTAALKEIRT
QYEAMASSNM HEAEEWYRSK FADLTDAAAR NAELLRQAKH EANDYRRQLQ SLTCDLESLR
GTNESLERQM REQEERHARE AASYQEALAR LEEEGQSLKD EMARHLQEYQ DLLNVKLALD
IEIATYRKLL EGEENRITIP VQTFSNLQIR ETSLDTKSVS EGHLKRNIVV KTVEMRDGEV
IKESKQEHKD VM
