GFD2_YEAST
ID GFD2_YEAST Reviewed; 566 AA.
AC P25370; D6VQX9;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Good for full DBP5 activity protein 2;
GN Name=GFD2; OrderedLocusNames=YCL036W; ORFNames=YCL187, YCL36W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1897318; DOI=10.1002/yea.320070513;
RA Rad M.R., Luetzenkirchen K., Xu G., Kleinhans U., Hollenberg C.P.;
RT "The complete sequence of a 11,953 bp fragment from C1G on chromosome III
RT encompasses four new open reading frames.";
RL Yeast 7:533-538(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=1574125; DOI=10.1038/357038a0;
RA Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA Sgouros J.G.;
RT "The complete DNA sequence of yeast chromosome III.";
RL Nature 357:38-46(1992).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP IDENTIFICATION, AND FUNCTION.
RX PubMed=12686617; DOI=10.1091/mbc.e02-09-0602;
RA Estruch F., Cole C.N.;
RT "An early function during transcription for the yeast mRNA export factor
RT Dbp5p/Rat8p suggested by its genetic and physical interactions with
RT transcription factor IIH components.";
RL Mol. Biol. Cell 14:1664-1676(2003).
CC -!- FUNCTION: High-copy suppressor of DBP5 mutation.
CC {ECO:0000269|PubMed:12686617}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X59720; CAA42380.1; -; Genomic_DNA.
DR EMBL; BK006937; DAA07448.1; -; Genomic_DNA.
DR PIR; S17477; S17477.
DR RefSeq; NP_009894.1; NM_001178681.1.
DR AlphaFoldDB; P25370; -.
DR BioGRID; 30947; 97.
DR DIP; DIP-2955N; -.
DR MINT; P25370; -.
DR STRING; 4932.YCL036W; -.
DR iPTMnet; P25370; -.
DR MaxQB; P25370; -.
DR PaxDb; P25370; -.
DR PRIDE; P25370; -.
DR EnsemblFungi; YCL036W_mRNA; YCL036W; YCL036W.
DR GeneID; 850321; -.
DR KEGG; sce:YCL036W; -.
DR SGD; S000000541; GFD2.
DR VEuPathDB; FungiDB:YCL036W; -.
DR eggNOG; ENOG502QTQR; Eukaryota.
DR GeneTree; ENSGT00940000176471; -.
DR HOGENOM; CLU_029052_0_0_1; -.
DR InParanoid; P25370; -.
DR OMA; DRANCIC; -.
DR BioCyc; YEAST:G3O-29295-MON; -.
DR PRO; PR:P25370; -.
DR Proteomes; UP000002311; Chromosome III.
DR RNAct; P25370; protein.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR040151; Gfd2/YDR514C-like.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR28083; PTHR28083; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
PE 4: Predicted;
KW Reference proteome.
FT CHAIN 1..566
FT /note="Good for full DBP5 activity protein 2"
FT /id="PRO_0000202543"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 64913 MW; 8F84105DD8772A9B CRC64;
MQVQKMVRDN SNNGSDKSVH WERRNNNGAG PRYRSRSGNT GALATKLSNG TLSVRGLVKD
RTGSGKIAGC VEAFLDARTQ LNTPWDRAKC NWLDQIDYYV QLRKTAFSKE LDQLRKPMID
AYVAEMRQKF DASYGQSRAQ LEAKLAQVDS EWHMVHGDVH AKLEKLVEER RFLKRLSDTI
VPPRSKRSQR LSPLTKEDRA NCICPQPKGM SDTAWFEAIQ KKMLGMNGTI KLLETEQKLL
ADEKNSVRKT FWPMVEAHSR SNEFAYLEKC IRLMASQRAI CFCLDIEAFE TNQNVITEIG
ISIYDPRENM VPSMVPITKN YHLIIEESLE LRNQKWVCDY KDCYLLGESY VLSLKECVHF
IQSLINYYLV PVTEEDKTWS RAFVGHHVSG DLKWLETIGV KFPGRGYEGH LDHTLLLAET
PGDLDVFILD TEQFYRKSYG EKGSSLGKIL RLFEIPHAFL HNAGNDAYYT LHLFMKFCDV
NFRKISGMDD VLKVMGQVKV WGERDVREPK VVPMSYAISI EEAVKNRTYR KGVKSSRKER
VCQTEFGGLT YFGTAKDAFT STLPTH
