GFOD1_HUMAN
ID GFOD1_HUMAN Reviewed; 390 AA.
AC Q9NXC2; A8E4L6; Q5T058; Q96JD4; Q9H5K2;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Glucose-fructose oxidoreductase domain-containing protein 1;
DE EC=1.-.-.-;
DE Flags: Precursor;
GN Name=GFOD1; Synonyms=C6orf114;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RC TISSUE=Fetal brain;
RA Shi J., Cai W., Xie Y.;
RT "Identification of dopamine responsive genes in glial cells by subtractive
RT hybridization.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- INTERACTION:
CC Q9NXC2; P48643: CCT5; NbExp=3; IntAct=EBI-8799578, EBI-355710;
CC Q9NXC2; P02489: CRYAA; NbExp=3; IntAct=EBI-8799578, EBI-6875961;
CC Q9NXC2; G5E9A7: DMWD; NbExp=3; IntAct=EBI-8799578, EBI-10976677;
CC Q9NXC2; Q8IZU0: FAM9B; NbExp=4; IntAct=EBI-8799578, EBI-10175124;
CC Q9NXC2; P28799: GRN; NbExp=3; IntAct=EBI-8799578, EBI-747754;
CC Q9NXC2; Q9ULV5-2: HSF4; NbExp=3; IntAct=EBI-8799578, EBI-12056251;
CC Q9NXC2; P04792: HSPB1; NbExp=3; IntAct=EBI-8799578, EBI-352682;
CC Q9NXC2; P42858: HTT; NbExp=9; IntAct=EBI-8799578, EBI-466029;
CC Q9NXC2; O60333-2: KIF1B; NbExp=3; IntAct=EBI-8799578, EBI-10975473;
CC Q9NXC2; Q92876: KLK6; NbExp=3; IntAct=EBI-8799578, EBI-2432309;
CC Q9NXC2; Q15323: KRT31; NbExp=3; IntAct=EBI-8799578, EBI-948001;
CC Q9NXC2; Q6A162: KRT40; NbExp=3; IntAct=EBI-8799578, EBI-10171697;
CC Q9NXC2; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-8799578, EBI-10171774;
CC Q9NXC2; P43360: MAGEA6; NbExp=6; IntAct=EBI-8799578, EBI-1045155;
CC Q9NXC2; P07196: NEFL; NbExp=3; IntAct=EBI-8799578, EBI-475646;
CC Q9NXC2; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-8799578, EBI-945833;
CC Q9NXC2; D3DTS7: PMP22; NbExp=3; IntAct=EBI-8799578, EBI-25882629;
CC Q9NXC2; O60260-5: PRKN; NbExp=3; IntAct=EBI-8799578, EBI-21251460;
CC Q9NXC2; P60891: PRPS1; NbExp=3; IntAct=EBI-8799578, EBI-749195;
CC Q9NXC2; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-8799578, EBI-396669;
CC Q9NXC2; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-8799578, EBI-5235340;
CC Q9NXC2; Q86WV8: TSC1; NbExp=3; IntAct=EBI-8799578, EBI-12806590;
CC Q9NXC2; O76024: WFS1; NbExp=3; IntAct=EBI-8799578, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9NXC2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NXC2-2; Sequence=VSP_024261;
CC Name=3;
CC IsoId=Q9NXC2-3; Sequence=VSP_041468;
CC -!- MISCELLANEOUS: [Isoform 3]: Dubious isoform. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000305}.
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DR EMBL; AK000337; BAA91093.1; -; mRNA.
DR EMBL; AF264036; AAK58533.1; -; mRNA.
DR EMBL; AK027010; BAB15624.1; -; mRNA.
DR EMBL; AL583828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL589984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471087; EAW55331.1; -; Genomic_DNA.
DR EMBL; BC066553; AAH66553.1; -; mRNA.
DR EMBL; BC119005; AAI19006.1; -; mRNA.
DR EMBL; BC124557; AAI24558.1; -; mRNA.
DR EMBL; BC148295; AAI48296.1; -; mRNA.
DR CCDS; CCDS4524.1; -. [Q9NXC2-1]
DR CCDS; CCDS56397.1; -. [Q9NXC2-2]
DR RefSeq; NP_001229557.1; NM_001242628.1. [Q9NXC2-2]
DR RefSeq; NP_001229558.1; NM_001242629.1.
DR RefSeq; NP_001229559.1; NM_001242630.1. [Q9NXC2-2]
DR RefSeq; NP_061861.1; NM_018988.3. [Q9NXC2-1]
DR RefSeq; XP_011513001.1; XM_011514699.2. [Q9NXC2-2]
DR AlphaFoldDB; Q9NXC2; -.
DR SMR; Q9NXC2; -.
DR BioGRID; 119954; 55.
DR IntAct; Q9NXC2; 44.
DR STRING; 9606.ENSP00000368589; -.
DR iPTMnet; Q9NXC2; -.
DR PhosphoSitePlus; Q9NXC2; -.
DR BioMuta; GFOD1; -.
DR DMDM; 74753042; -.
DR EPD; Q9NXC2; -.
DR jPOST; Q9NXC2; -.
DR MassIVE; Q9NXC2; -.
DR MaxQB; Q9NXC2; -.
DR PaxDb; Q9NXC2; -.
DR PeptideAtlas; Q9NXC2; -.
DR PRIDE; Q9NXC2; -.
DR ProteomicsDB; 83071; -. [Q9NXC2-1]
DR ProteomicsDB; 83072; -. [Q9NXC2-2]
DR ProteomicsDB; 83073; -. [Q9NXC2-3]
DR Antibodypedia; 24958; 34 antibodies from 13 providers.
DR DNASU; 54438; -.
DR Ensembl; ENST00000379284.1; ENSP00000368586.1; ENSG00000145990.11. [Q9NXC2-2]
DR Ensembl; ENST00000379287.4; ENSP00000368589.3; ENSG00000145990.11. [Q9NXC2-1]
DR Ensembl; ENST00000612338.4; ENSP00000479493.1; ENSG00000145990.11. [Q9NXC2-2]
DR GeneID; 54438; -.
DR KEGG; hsa:54438; -.
DR MANE-Select; ENST00000379287.4; ENSP00000368589.3; NM_018988.4; NP_061861.1.
DR UCSC; uc003nar.4; human. [Q9NXC2-1]
DR CTD; 54438; -.
DR DisGeNET; 54438; -.
DR GeneCards; GFOD1; -.
DR HGNC; HGNC:21096; GFOD1.
DR HPA; ENSG00000145990; Tissue enhanced (brain).
DR neXtProt; NX_Q9NXC2; -.
DR OpenTargets; ENSG00000145990; -.
DR PharmGKB; PA128394667; -.
DR VEuPathDB; HostDB:ENSG00000145990; -.
DR eggNOG; KOG2742; Eukaryota.
DR GeneTree; ENSGT00940000160837; -.
DR HOGENOM; CLU_023194_8_0_1; -.
DR InParanoid; Q9NXC2; -.
DR OMA; NQKDYVH; -.
DR OrthoDB; 673027at2759; -.
DR PhylomeDB; Q9NXC2; -.
DR TreeFam; TF323246; -.
DR PathwayCommons; Q9NXC2; -.
DR Reactome; R-HSA-9013406; RHOQ GTPase cycle.
DR SignaLink; Q9NXC2; -.
DR BioGRID-ORCS; 54438; 8 hits in 1081 CRISPR screens.
DR ChiTaRS; GFOD1; human.
DR GenomeRNAi; 54438; -.
DR Pharos; Q9NXC2; Tdark.
DR PRO; PR:Q9NXC2; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9NXC2; protein.
DR Bgee; ENSG00000145990; Expressed in cerebellar vermis and 206 other tissues.
DR ExpressionAtlas; Q9NXC2; baseline and differential.
DR Genevisible; Q9NXC2; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Oxidoreductase; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..390
FT /note="Glucose-fructose oxidoreductase domain-containing
FT protein 1"
FT /id="PRO_0000282968"
FT VAR_SEQ 1..390
FT /note="MLPGVGVFGTSLTARVIIPLLKDEGFAVKALWGRTQEEAEELAKEMSVPFYT
FT SRIDEVLLHQDVDLVCINLPPPLTRQIAVKTLGIGKNVICDRTATPLDAFRMTSAAHYY
FT PKLMSIMGNVLRFLPAFVRMKQLIEEGYVGEPLVCEVQVHGGSLLGKKYNWSCDDLMGG
FT GGLHSVGTYIIDLLTFLTGQKAVKVHGLLKTFVKQTDHIKGIRQITSDDFCTFQMVLEG
FT GVCCTVTLNFNVPGEFKQDVTVVGSAGRLLAVGTDLYGQRNSAPEQELLVQDATPVSNS
FT LLPEKAFSDIPSPYLRGTIKMMQAVRQAFQDQDDRRTWDGRPLTMAATFDDCLYALCVV
FT DTIKRSSQTGEWQNIAIMTEEPELSPAYLISEAMRRSRMSLYC -> MGDSRRDVLHEP
FT AIALLSSPQTQSRLQIDAFIARRCWGSQWDITGYIHQQDFPTAVFIGFSNEFNICIPHP
FT FTEWLQCVRKYSQSWGVRKGQRHIRYGMCSERTHHLSRTYSSLLEREEKLAFYGVLTMC
FT QIWCET (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_041468"
FT VAR_SEQ 1..103
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024261"
FT VARIANT Q9NXC2-3:134
FT /note="C -> S (in dbSNP:rs766773)"
FT /evidence="ECO:0000305"
FT /id="VAR_082824"
SQ SEQUENCE 390 AA; 43158 MW; 59C3FA2D6D837C8A CRC64;
MLPGVGVFGT SLTARVIIPL LKDEGFAVKA LWGRTQEEAE ELAKEMSVPF YTSRIDEVLL
HQDVDLVCIN LPPPLTRQIA VKTLGIGKNV ICDRTATPLD AFRMTSAAHY YPKLMSIMGN
VLRFLPAFVR MKQLIEEGYV GEPLVCEVQV HGGSLLGKKY NWSCDDLMGG GGLHSVGTYI
IDLLTFLTGQ KAVKVHGLLK TFVKQTDHIK GIRQITSDDF CTFQMVLEGG VCCTVTLNFN
VPGEFKQDVT VVGSAGRLLA VGTDLYGQRN SAPEQELLVQ DATPVSNSLL PEKAFSDIPS
PYLRGTIKMM QAVRQAFQDQ DDRRTWDGRP LTMAATFDDC LYALCVVDTI KRSSQTGEWQ
NIAIMTEEPE LSPAYLISEA MRRSRMSLYC
