GFOD1_MOUSE
ID GFOD1_MOUSE Reviewed; 390 AA.
AC Q3UHD2; B9EI39;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Glucose-fructose oxidoreductase domain-containing protein 1;
DE EC=1.-.-.-;
DE Flags: Precursor;
GN Name=Gfod1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000305}.
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DR EMBL; AK147458; BAE27925.1; -; mRNA.
DR EMBL; BC139026; AAI39027.1; -; mRNA.
DR EMBL; BC139027; AAI39028.1; -; mRNA.
DR CCDS; CCDS26477.1; -.
DR RefSeq; NP_001028571.1; NM_001033399.4.
DR AlphaFoldDB; Q3UHD2; -.
DR SMR; Q3UHD2; -.
DR BioGRID; 236559; 1.
DR STRING; 10090.ENSMUSP00000062662; -.
DR iPTMnet; Q3UHD2; -.
DR PhosphoSitePlus; Q3UHD2; -.
DR SwissPalm; Q3UHD2; -.
DR EPD; Q3UHD2; -.
DR MaxQB; Q3UHD2; -.
DR PaxDb; Q3UHD2; -.
DR PeptideAtlas; Q3UHD2; -.
DR PRIDE; Q3UHD2; -.
DR ProteomicsDB; 267429; -.
DR Antibodypedia; 24958; 34 antibodies from 13 providers.
DR Ensembl; ENSMUST00000055341; ENSMUSP00000062662; ENSMUSG00000051335.
DR GeneID; 328232; -.
DR KEGG; mmu:328232; -.
DR UCSC; uc007qfx.1; mouse.
DR CTD; 54438; -.
DR MGI; MGI:2145304; Gfod1.
DR VEuPathDB; HostDB:ENSMUSG00000051335; -.
DR eggNOG; KOG2742; Eukaryota.
DR GeneTree; ENSGT00940000160837; -.
DR HOGENOM; CLU_023194_8_0_1; -.
DR InParanoid; Q3UHD2; -.
DR OMA; NQKDYVH; -.
DR OrthoDB; 673027at2759; -.
DR PhylomeDB; Q3UHD2; -.
DR TreeFam; TF323246; -.
DR Reactome; R-MMU-9013406; RHOQ GTPase cycle.
DR BioGRID-ORCS; 328232; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Gfod1; mouse.
DR PRO; PR:Q3UHD2; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q3UHD2; protein.
DR Bgee; ENSMUSG00000051335; Expressed in cerebellar vermis and 187 other tissues.
DR ExpressionAtlas; Q3UHD2; baseline and differential.
DR Genevisible; Q3UHD2; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 1: Evidence at protein level;
KW Oxidoreductase; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..390
FT /note="Glucose-fructose oxidoreductase domain-containing
FT protein 1"
FT /id="PRO_0000282969"
SQ SEQUENCE 390 AA; 43286 MW; 718D2A2407DBE93D CRC64;
MLPGVGVFGT SLTARVIIPL LKDEGFAVKA LWGRTQEEAE ELAKEMSVPF YTSRIDEVLL
HQDVDLVCIN LPPPLTRQIA VKTLGIGKNV ICDRTATPLD AFRMMSAAHY YPKLMSIMGN
VLRFLPAFVR MKQLIEEGYV GELLVCEVQV HSGSLLGKKY NWSCDDLMGG GGLHSVGTYI
IDLLTFLTGQ KAVKVHGLLK TFVKQTDHIK GIRQITSDDF CTFQMVLEGG VCCTVTLNFN
VPGEFKQDVT VVGSAGRLLA VGTDLYGQRN SAPEQELLLQ DTTSVSNSLL PEKAFSDIPS
PYLRGTMKMM QAVRQAFQDQ DDRRTWDGRP LTMAATFDDC LYALCVVDTI KRSSQTGEWQ
NIAIMTEEPE LSPAYLISEA MRRSRMSLYC
