ID   GFOD2_BOVIN             Reviewed;         385 AA.
AC   Q5BIP5;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Glucose-fructose oxidoreductase domain-containing protein 2;
DE            EC=1.-.-.-;
DE   Flags: Precursor;
GN   Name=GFOD2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes matrix assembly. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000305}.
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DR   EMBL; BT021179; AAX31361.1; -; mRNA.
DR   EMBL; BT025419; ABF57375.1; -; mRNA.
DR   EMBL; BC123696; AAI23697.1; -; mRNA.
DR   RefSeq; NP_001014863.1; NM_001014863.2.
DR   RefSeq; XP_005218537.1; XM_005218480.3.
DR   RefSeq; XP_005218538.1; XM_005218481.3.
DR   RefSeq; XP_005218544.1; XM_005218487.3.
DR   RefSeq; XP_010812737.1; XM_010814435.2.
DR   RefSeq; XP_015331205.1; XM_015475719.1.
DR   RefSeq; XP_015331206.1; XM_015475720.1.
DR   AlphaFoldDB; Q5BIP5; -.
DR   SMR; Q5BIP5; -.
DR   STRING; 9913.ENSBTAP00000025164; -.
DR   PaxDb; Q5BIP5; -.
DR   Ensembl; ENSBTAT00000025164; ENSBTAP00000025164; ENSBTAG00000018908.
DR   GeneID; 507361; -.
DR   KEGG; bta:507361; -.
DR   CTD; 81577; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018908; -.
DR   VGNC; VGNC:29329; GFOD2.
DR   eggNOG; KOG2742; Eukaryota.
DR   GeneTree; ENSGT00940000156501; -.
DR   HOGENOM; CLU_023194_8_0_1; -.
DR   InParanoid; Q5BIP5; -.
DR   OMA; EMPLPHL; -.
DR   OrthoDB; 673027at2759; -.
DR   TreeFam; TF323246; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000018908; Expressed in surface of tongue and 103 other tissues.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR   InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR   InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01408; GFO_IDH_MocA; 1.
DR   Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Extracellular matrix; Oxidoreductase; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..385
FT                   /note="Glucose-fructose oxidoreductase domain-containing
FT                   protein 2"
FT                   /id="PRO_0000282971"
SQ   SEQUENCE   385 AA;  42145 MW;  5B936B97AED5AFCF CRC64;
     MKMLPGVGVF GTGSSARVLV PLLRAEGFTV QALWGKTEEE AKQLAEEMNI AFYTSRTDDV
     LLHQDVDLVC INMPPPLTRQ ISVKALGIGK NVVCEKAATS VDAFRMVTAS RYYPQLMSLV
     GNVLRFLPAF VRMKQLIAEH YVGAVMICDA RVYSGSLLSP NYGWICDELM GGGGLHTMGT
     YIVDLLTHLT GQRAEKVHGL LKTFVRQNAA IRGIRHVTSD DFCFFQMLMG GGVCSTVTLN
     FNMPGAFVHE VMVVGSAGRL VARGADLYGQ KNSAPQEELL LRDSLAVGAG LPEQGAQDVP
     LLYLKGMVYM VQALRQSFQG QGDRRTWDHT PVSMAASFED GLYMQSVVDA IKRSSRSGEW
     EAVEVLAEEP DANQNLCEAL QRNNL