GFOD2_HUMAN
ID GFOD2_HUMAN Reviewed; 385 AA.
AC Q3B7J2; Q69YL9; Q6UXX6; Q7L648; Q8TE86; Q9BQ07; R4GNG5;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Glucose-fructose oxidoreductase domain-containing protein 2;
DE EC=1.-.-.-;
DE Flags: Precursor;
GN Name=GFOD2; ORFNames=UNQ9430/PRO34691;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Lung, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-385 (ISOFORMS 1/2).
RC TISSUE=Melanoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: Promotes matrix assembly. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3B7J2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3B7J2-2; Sequence=VSP_024262;
CC Name=3;
CC IsoId=Q3B7J2-3; Sequence=VSP_055185, VSP_055186;
CC -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ88536.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY358169; AAQ88536.1; ALT_INIT; mRNA.
DR EMBL; AK074382; BAB85066.1; -; mRNA.
DR EMBL; AK307280; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC010530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC000757; AAH00757.1; -; mRNA.
DR EMBL; BC002943; AAH02943.2; -; mRNA.
DR EMBL; BC107585; AAI07586.1; -; mRNA.
DR EMBL; AL832904; CAH10637.1; -; mRNA.
DR CCDS; CCDS10845.1; -. [Q3B7J2-1]
DR CCDS; CCDS59268.1; -. [Q3B7J2-3]
DR RefSeq; NP_001230579.1; NM_001243650.1. [Q3B7J2-3]
DR RefSeq; NP_110446.3; NM_030819.3. [Q3B7J2-1]
DR RefSeq; XP_006721351.1; XM_006721288.3. [Q3B7J2-2]
DR RefSeq; XP_016879227.1; XM_017023738.1.
DR AlphaFoldDB; Q3B7J2; -.
DR SMR; Q3B7J2; -.
DR BioGRID; 123537; 7.
DR IntAct; Q3B7J2; 4.
DR STRING; 9606.ENSP00000268797; -.
DR iPTMnet; Q3B7J2; -.
DR PhosphoSitePlus; Q3B7J2; -.
DR BioMuta; GFOD2; -.
DR DMDM; 121942382; -.
DR EPD; Q3B7J2; -.
DR MassIVE; Q3B7J2; -.
DR MaxQB; Q3B7J2; -.
DR PaxDb; Q3B7J2; -.
DR PeptideAtlas; Q3B7J2; -.
DR PRIDE; Q3B7J2; -.
DR ProteomicsDB; 61654; -. [Q3B7J2-1]
DR ProteomicsDB; 61655; -. [Q3B7J2-2]
DR TopDownProteomics; Q3B7J2-1; -. [Q3B7J2-1]
DR Antibodypedia; 29615; 180 antibodies from 22 providers.
DR DNASU; 81577; -.
DR Ensembl; ENST00000268797.12; ENSP00000268797.7; ENSG00000141098.13. [Q3B7J2-1]
DR Ensembl; ENST00000602279.2; ENSP00000478260.1; ENSG00000141098.13. [Q3B7J2-3]
DR Ensembl; ENST00000602496.1; ENSP00000473641.1; ENSG00000141098.13. [Q3B7J2-3]
DR GeneID; 81577; -.
DR KEGG; hsa:81577; -.
DR MANE-Select; ENST00000268797.12; ENSP00000268797.7; NM_030819.4; NP_110446.3.
DR UCSC; uc002eub.4; human. [Q3B7J2-1]
DR CTD; 81577; -.
DR DisGeNET; 81577; -.
DR GeneCards; GFOD2; -.
DR HGNC; HGNC:28159; GFOD2.
DR HPA; ENSG00000141098; Low tissue specificity.
DR neXtProt; NX_Q3B7J2; -.
DR OpenTargets; ENSG00000141098; -.
DR PharmGKB; PA144596430; -.
DR VEuPathDB; HostDB:ENSG00000141098; -.
DR eggNOG; KOG2742; Eukaryota.
DR GeneTree; ENSGT00940000156501; -.
DR HOGENOM; CLU_023194_8_0_1; -.
DR InParanoid; Q3B7J2; -.
DR OMA; EMPLPHL; -.
DR OrthoDB; 673027at2759; -.
DR PhylomeDB; Q3B7J2; -.
DR TreeFam; TF323246; -.
DR PathwayCommons; Q3B7J2; -.
DR SignaLink; Q3B7J2; -.
DR BioGRID-ORCS; 81577; 11 hits in 1075 CRISPR screens.
DR ChiTaRS; GFOD2; human.
DR GenomeRNAi; 81577; -.
DR Pharos; Q3B7J2; Tdark.
DR PRO; PR:Q3B7J2; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q3B7J2; protein.
DR Bgee; ENSG00000141098; Expressed in lower esophagus mucosa and 154 other tissues.
DR ExpressionAtlas; Q3B7J2; baseline and differential.
DR Genevisible; Q3B7J2; HS.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Extracellular matrix; Oxidoreductase;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..385
FT /note="Glucose-fructose oxidoreductase domain-containing
FT protein 2"
FT /id="PRO_0000282972"
FT VAR_SEQ 1..105
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024262"
FT VAR_SEQ 87..112
FT /note="GIGKNVVCEKAATSVDAFRMVTASRY -> GTPGRPQQGQIMSLPLGSPLRV
FT TPLL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_055185"
FT VAR_SEQ 113..385
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_055186"
FT VARIANT 231
FT /note="G -> V (in dbSNP:rs11539687)"
FT /id="VAR_054433"
FT CONFLICT 8
FT /note="G -> D (in Ref. 2; BAB85066)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 385 AA; 42255 MW; D516EE4CC5CF5667 CRC64;
MKMLPGVGVF GTGSSARVLV PLLRAEGFTV EALWGKTEEE AKQLAEEMNI AFYTSRTDDI
LLHQDVDLVC ISIPPPLTRQ ISVKALGIGK NVVCEKAATS VDAFRMVTAS RYYPQLMSLV
GNVLRFLPAF VRMKQLISEH YVGAVMICDA RIYSGSLLSP SYGWICDELM GGGGLHTMGT
YIVDLLTHLT GRRAEKVHGL LKTFVRQNAA IRGIRHVTSD DFCFFQMLMG GGVCSTVTLN
FNMPGAFVHE VMVVGSAGRL VARGADLYGQ KNSATQEELL LRDSLAVGAG LPEQGPQDVP
LLYLKGMVYM VQALRQSFQG QGDRRTWDRT PVSMAASFED GLYMQSVVDA IKRSSRSGEW
EAVEVLTEEP DTNQNLCEAL QRNNL
