GFOD2_MOUSE
ID GFOD2_MOUSE Reviewed; 385 AA.
AC Q9CYH5;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Glucose-fructose oxidoreductase domain-containing protein 2;
DE EC=1.-.-.-;
DE Flags: Precursor;
GN Name=Gfod2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=18757743; DOI=10.1073/pnas.0803640105;
RA Manabe R., Tsutsui K., Yamada T., Kimura M., Nakano I., Shimono C.,
RA Sanzen N., Furutani Y., Fukuda T., Oguri Y., Shimamoto K., Kiyozumi D.,
RA Sato Y., Sado Y., Senoo H., Yamashina S., Fukuda S., Kawai J., Sugiura N.,
RA Kimata K., Hayashizaki Y., Sekiguchi K.;
RT "Transcriptome-based systematic identification of extracellular matrix
RT proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:12849-12854(2008).
CC -!- FUNCTION: Promotes matrix assembly. {ECO:0000269|PubMed:18757743}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000269|PubMed:18757743}.
CC -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000305}.
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DR EMBL; AK017684; BAB30872.1; -; mRNA.
DR EMBL; AK141521; BAE24716.1; -; mRNA.
DR EMBL; BC013623; AAH13623.1; -; mRNA.
DR CCDS; CCDS22612.1; -.
DR RefSeq; NP_081745.1; NM_027469.4.
DR RefSeq; XP_017168447.1; XM_017312958.1.
DR AlphaFoldDB; Q9CYH5; -.
DR SMR; Q9CYH5; -.
DR STRING; 10090.ENSMUSP00000013294; -.
DR iPTMnet; Q9CYH5; -.
DR PhosphoSitePlus; Q9CYH5; -.
DR MaxQB; Q9CYH5; -.
DR PaxDb; Q9CYH5; -.
DR PRIDE; Q9CYH5; -.
DR ProteomicsDB; 266794; -.
DR Antibodypedia; 29615; 180 antibodies from 22 providers.
DR DNASU; 70575; -.
DR Ensembl; ENSMUST00000013294; ENSMUSP00000013294; ENSMUSG00000013150.
DR GeneID; 70575; -.
DR KEGG; mmu:70575; -.
DR UCSC; uc009neb.1; mouse.
DR CTD; 81577; -.
DR MGI; MGI:1917825; Gfod2.
DR VEuPathDB; HostDB:ENSMUSG00000013150; -.
DR eggNOG; KOG2742; Eukaryota.
DR GeneTree; ENSGT00940000156501; -.
DR HOGENOM; CLU_023194_8_0_1; -.
DR InParanoid; Q9CYH5; -.
DR OMA; EMPLPHL; -.
DR OrthoDB; 673027at2759; -.
DR PhylomeDB; Q9CYH5; -.
DR TreeFam; TF323246; -.
DR BioGRID-ORCS; 70575; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Gfod2; mouse.
DR PRO; PR:Q9CYH5; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9CYH5; protein.
DR Bgee; ENSMUSG00000013150; Expressed in cortical plate and 235 other tissues.
DR ExpressionAtlas; Q9CYH5; baseline and differential.
DR Genevisible; Q9CYH5; MM.
DR GO; GO:0031012; C:extracellular matrix; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0030198; P:extracellular matrix organization; IDA:MGI.
DR InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 2: Evidence at transcript level;
KW Extracellular matrix; Oxidoreductase; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..385
FT /note="Glucose-fructose oxidoreductase domain-containing
FT protein 2"
FT /id="PRO_0000282973"
SQ SEQUENCE 385 AA; 42242 MW; B99702BBCFEA4210 CRC64;
MKLLPGVGVF GTGSSARVLV PLLRAEGFTV EALWGKTEEE AKQLAEEMNI TFYTSRTDDV
LLHQDVDLVC INIPPPLTRQ ISVKALGIGK NVVCEKAATS MDAFRMVTAS RYYPQLMSLV
GNVLRFLPAF VRMKQLIAEH YVGAVMICDA RIYSGSLLSP SYGWICDELM GGGGLHTMGT
YIVDLLTHLT GQKAEKVHGL LKTFVRQNAT IRGIRHVTSD DFCFFQMLMG GGVCSTVTLN
FNMPGAFVHE VMVVGSAGRL VARGADLYGQ KNSAAQEELL VRDSLAVGAG LPEQGPQDVP
LLYLKGMVYM VQALRQSFQG QGDRRTWDRT PVSMAASFED GLYMQSVVDA IKRSSRSGEW
ETVEMLAEEP DANQNLSETL QRNNL
