ID   GFRA2_CHICK             Reviewed;         465 AA.
AC   O13157;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=GDNF family receptor alpha-2;
DE            Short=GDNF receptor alpha-2;
DE            Short=GDNFR-alpha-2;
DE            Short=GFR-alpha-2;
DE   AltName: Full=GDNF receptor beta;
DE            Short=GDNFR-beta;
DE   AltName: Full=Neurturin receptor alpha;
DE            Short=NRTNR-alpha;
DE            Short=NTNR-alpha;
DE   Flags: Precursor;
GN   Name=GFRA2; Synonyms=GDNFRB;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=9192899; DOI=10.1038/42729;
RA   Buj-Bello A., Adu J., Pinon L.G.P., Horton A., Thompson J., Rosenthal A.,
RA   Chinchetru M., Buchman V.L., Davies A.M.;
RT   "Neurturin responsiveness requires a GPI-linked receptor and the Ret
RT   receptor tyrosine kinase.";
RL   Nature 387:721-724(1997).
CC   -!- FUNCTION: Receptor for neurturin. Mediates the NRTN-induced
CC       autophosphorylation and activation of the RET receptor. Also able to
CC       mediate GDNF signaling through the RET tyrosine kinase receptor (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC   -!- SIMILARITY: Belongs to the GDNFR family. {ECO:0000305}.
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DR   EMBL; U90542; AAB61571.1; -; mRNA.
DR   RefSeq; NP_990432.1; NM_205101.1.
DR   AlphaFoldDB; O13157; -.
DR   SMR; O13157; -.
DR   STRING; 9031.ENSGALP00000002763; -.
DR   PaxDb; O13157; -.
DR   GeneID; 395993; -.
DR   KEGG; gga:395993; -.
DR   CTD; 2675; -.
DR   VEuPathDB; HostDB:geneid_395993; -.
DR   eggNOG; ENOG502QS3P; Eukaryota.
DR   InParanoid; O13157; -.
DR   OrthoDB; 482696at2759; -.
DR   PhylomeDB; O13157; -.
DR   PRO; PR:O13157; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR   GO; GO:0016167; F:glial cell-derived neurotrophic factor receptor activity; IBA:GO_Central.
DR   GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR   InterPro; IPR016017; GDNF/GAS1.
DR   InterPro; IPR037193; GDNF_alpha.
DR   InterPro; IPR003438; GDNF_rcpt.
DR   InterPro; IPR003504; GDNF_rcpt_a2.
DR   InterPro; IPR017372; Glial_neurotroph_fac_rcpt_a1/2.
DR   PANTHER; PTHR10269; PTHR10269; 1.
DR   Pfam; PF02351; GDNF; 3.
DR   PIRSF; PIRSF038071; GDNF_family_receptor_alpha; 1.
DR   PRINTS; PR01318; GDNFRALPHA2.
DR   PRINTS; PR01316; GDNFRECEPTOR.
DR   SMART; SM00907; GDNF; 3.
DR   SUPFAM; SSF110035; SSF110035; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Receptor;
KW   Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..445
FT                   /note="GDNF family receptor alpha-2"
FT                   /id="PRO_0000010783"
FT   PROPEP          446..465
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000010784"
FT   LIPID           445
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        355
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        387
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        412
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   465 AA;  51909 MW;  22CD9024ED971F06 CRC64;
     MILANAFCIV LFVDETLRSL AAPPSPPGQD LQGWRVPVDC IRANKLCAAE GSCSSRYRTL
     RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMR KEIQCLQVYW SIHLGLAEGE
     EFYEASPYEP ITSRLSDIFR LASIFSGMDP ATNSKSNHCL DAAKACNLND NCKRLRSGYI
     STCSKEISAT EHCSRRKCHK ALRQFFDNVP SEYTYRLLFC SCKDQACAEP RRQTIVPFCS
     YEDKEKPNCL DLRNVCRADH LCRSRLADFH ANCQASFQSL TSCPGDNYQA CLGSYTGLIG
     FDMTPNYVDA STTSITISPW CSCKGSGNLE EECEKFLRDF TENPCLRNAI QAFGNGTDVN
     LSPKNPSPPI TMLPKVEKSP ALPDDINDSN TMYDTSIITT CTSIQEHGQK LNKSKEQSLC
     YSETQLTTDT MPDQKTFVDQ KAAGSRHRAA RILPAVPIVL LKLLL