ID   GFRA2_PONAB             Reviewed;         464 AA.
AC   Q5RAD6; Q5R9T3;
DT   14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 2.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=GDNF family receptor alpha-2;
DE            Short=GDNF receptor alpha-2;
DE            Short=GDNFR-alpha-2;
DE            Short=GFR-alpha-2;
DE   Flags: Precursor;
GN   Name=GFRA2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, and Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for neurturin. Mediates the NRTN-induced
CC       autophosphorylation and activation of the RET receptor. Also able to
CC       mediate GDNF signaling through the RET tyrosine kinase receptor (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SORL1. {ECO:0000250|UniProtKB:O00451}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC       anchor {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GDNFR family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR859081; CAH91274.1; -; mRNA.
DR   EMBL; CR859299; CAH91477.1; -; mRNA.
DR   RefSeq; NP_001128806.1; NM_001135334.1.
DR   AlphaFoldDB; Q5RAD6; -.
DR   SMR; Q5RAD6; -.
DR   STRING; 9601.ENSPPYP00000020622; -.
DR   Ensembl; ENSPPYT00000021451; ENSPPYP00000020622; ENSPPYG00000018405.
DR   GeneID; 100189713; -.
DR   eggNOG; ENOG502QS3P; Eukaryota.
DR   GeneTree; ENSGT00940000156168; -.
DR   HOGENOM; CLU_040179_1_1_1; -.
DR   InParanoid; Q5RAD6; -.
DR   OrthoDB; 482696at2759; -.
DR   Proteomes; UP000001595; Chromosome 8.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   InterPro; IPR016017; GDNF/GAS1.
DR   InterPro; IPR037193; GDNF_alpha.
DR   InterPro; IPR003438; GDNF_rcpt.
DR   InterPro; IPR003504; GDNF_rcpt_a2.
DR   InterPro; IPR017372; Glial_neurotroph_fac_rcpt_a1/2.
DR   PANTHER; PTHR10269; PTHR10269; 1.
DR   Pfam; PF02351; GDNF; 3.
DR   PIRSF; PIRSF038071; GDNF_family_receptor_alpha; 1.
DR   PRINTS; PR01318; GDNFRALPHA2.
DR   PRINTS; PR01316; GDNFRECEPTOR.
DR   SMART; SM00907; GDNF; 3.
DR   SUPFAM; SSF110035; SSF110035; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Receptor;
KW   Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..444
FT                   /note="GDNF family receptor alpha-2"
FT                   /id="PRO_0000259971"
FT   PROPEP          445..464
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000259972"
FT   LIPID           444
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        357
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        413
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        262
FT                   /note="H -> R (in Ref. 1; CAH91274)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        293
FT                   /note="C -> Y (in Ref. 1; CAH91477)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   464 AA;  51542 MW;  8634CA04B7A47AAE CRC64;
     MILANVFCLF FFLDETLRSL ASPSSLQGPE LHGWRPPVDC VRANELCAAE SNCSSRYRTL
     RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK KELQCLQIYW SIHLGLTEGE
     EFYEASPYEP VTSRLSDIFR LASIFSGTGA DPVVSAKSNH CLDAAKACNL NDNCKKLRSS
     YISICNREIS PTERCNRRKC HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS
     CSYEDKEKPN CLDLRGVCRT DHLCRSRLAD FHANCRASYQ TVTSCPADNY QACLGSYAGM
     IGFDMTPNYV DSSPTGIVVS PWCSCRGSGN MEEECEKFLR DFTENPCLRN AIQAFGNGTD
     VNVSPKGPLF QATQAPRAEK TPSLPDDLSD STSLGTSVIT TCTSVQEQGL KANNSKELSM
     CFTELTTNII PGSNKVIKPN SGPSRARPSA ALTVLSVLML KLAL