GFRA3_MOUSE
ID GFRA3_MOUSE Reviewed; 397 AA.
AC O35118; O35325; O55243; Q6NZC2; Q8C8L9;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=GDNF family receptor alpha-3;
DE Short=GDNF receptor alpha-3;
DE Short=GDNFR-alpha-3;
DE Short=GFR-alpha-3;
DE Flags: Precursor;
GN Name=Gfra3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=9535755; DOI=10.1006/bbrc.1998.8361;
RA Nomoto S., Ito S., Yang L.-X., Kiuchi K.;
RT "Molecular cloning and expression analysis of GFR alpha-3, a novel cDNA
RT related to GDNFR alpha and NTNR-alpha.";
RL Biochem. Biophys. Res. Commun. 244:849-853(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9749804; DOI=10.1046/j.1460-9568.1998.00192.x;
RA Widenfalk J., Tomac A., Lindqvist E., Hoffer B., Olson L.;
RT "GFRalpha-3, a protein related to GFRalpha-1, is expressed in developing
RT peripheral neurons and ensheathing cells.";
RL Eur. J. Neurosci. 10:1508-1517(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9448325; DOI=10.1073/pnas.95.3.1295;
RA Naveilhan P., Baudet C., Mikaels A., Shen L., Westphal H., Ernfors P.;
RT "Expression and regulation of GFRalpha3, a glial cell line-derived
RT neurotrophic factor family receptor.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:1295-1300(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9576965; DOI=10.1073/pnas.95.10.5801;
RA Baloh R.H., Gorodinsky A., Golden J.P., Tansey M.G., Keck C.L.,
RA Popescu N.C., Johnson E.M. Jr., Milbrandt J.;
RT "GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor
RT family.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:5801-5806(1998).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9608533; DOI=10.1006/mcne.1998.0667;
RA Trupp M., Raynoschek C., Belluardo N., Ibanez C.F.;
RT "Multiple GPI-anchored receptors control GDNF-dependent and independent
RT activation of the c-Ret receptor tyrosine kinase.";
RL Mol. Cell. Neurosci. 11:47-63(1998).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Adrenal gland;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for the glial cell line-derived neurotrophic factor,
CC artemin. Mediates the artemin-induced autophosphorylation and
CC activation of the RET receptor tyrosine kinase (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SORL1. {ECO:0000250|UniProtKB:O60609}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC anchor {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GDNFR family. {ECO:0000305}.
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DR EMBL; AB008833; BAA23562.1; -; mRNA.
DR EMBL; AF041842; AAC23558.1; -; mRNA.
DR EMBL; AF036163; AAC24468.1; -; mRNA.
DR EMBL; AF051766; AAC24354.1; -; mRNA.
DR EMBL; AF020305; AAB70931.1; -; mRNA.
DR EMBL; AK046542; BAC32778.1; -; mRNA.
DR EMBL; BC066202; AAH66202.1; -; mRNA.
DR CCDS; CCDS29133.1; -.
DR PIR; JE0082; JE0082.
DR RefSeq; NP_034410.3; NM_010280.4.
DR AlphaFoldDB; O35118; -.
DR SMR; O35118; -.
DR BioGRID; 199906; 2.
DR STRING; 10090.ENSMUSP00000025224; -.
DR GlyGen; O35118; 3 sites.
DR PhosphoSitePlus; O35118; -.
DR PaxDb; O35118; -.
DR PRIDE; O35118; -.
DR ProteomicsDB; 267431; -.
DR Antibodypedia; 14907; 323 antibodies from 36 providers.
DR DNASU; 14587; -.
DR Ensembl; ENSMUST00000025224; ENSMUSP00000025224; ENSMUSG00000024366.
DR GeneID; 14587; -.
DR KEGG; mmu:14587; -.
DR UCSC; uc008ele.2; mouse.
DR CTD; 2676; -.
DR MGI; MGI:1201403; Gfra3.
DR VEuPathDB; HostDB:ENSMUSG00000024366; -.
DR eggNOG; ENOG502QWSW; Eukaryota.
DR GeneTree; ENSGT00940000161256; -.
DR HOGENOM; CLU_040179_3_0_1; -.
DR InParanoid; O35118; -.
DR OMA; NLQDECE; -.
DR OrthoDB; 921584at2759; -.
DR PhylomeDB; O35118; -.
DR TreeFam; TF331647; -.
DR Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR Reactome; R-MMU-8853659; RET signaling.
DR BioGRID-ORCS; 14587; 3 hits in 72 CRISPR screens.
DR PRO; PR:O35118; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; O35118; protein.
DR Bgee; ENSMUSG00000024366; Expressed in lumbar dorsal root ganglion and 89 other tissues.
DR Genevisible; O35118; MM.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0008046; F:axon guidance receptor activity; IMP:MGI.
DR GO; GO:0015026; F:coreceptor activity; TAS:MGI.
DR GO; GO:0016167; F:glial cell-derived neurotrophic factor receptor activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IMP:MGI.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR GO; GO:0048666; P:neuron development; IMP:MGI.
DR GO; GO:0001764; P:neuron migration; IMP:MGI.
DR GO; GO:0048485; P:sympathetic nervous system development; IMP:MGI.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:MGI.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR037193; GDNF_alpha.
DR InterPro; IPR003438; GDNF_rcpt.
DR InterPro; IPR003505; GDNF_rcpt_A3.
DR PANTHER; PTHR10269; PTHR10269; 1.
DR Pfam; PF02351; GDNF; 3.
DR PRINTS; PR01319; GDNFRALPHA3.
DR PRINTS; PR01316; GDNFRECEPTOR.
DR SMART; SM00907; GDNF; 3.
DR SUPFAM; SSF110035; SSF110035; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Receptor;
KW Reference proteome; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..371
FT /note="GDNF family receptor alpha-3"
FT /id="PRO_0000010791"
FT PROPEP 372..397
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010792"
FT LIPID 371
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 145
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 306
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 5..6
FT /note="WS -> LE (in Ref. 2; AAC23558 and 3; AAC24468)"
FT /evidence="ECO:0000305"
FT CONFLICT 66
FT /note="S -> C (in Ref. 6; BAC32778)"
FT /evidence="ECO:0000305"
FT CONFLICT 218
FT /note="A -> P (in Ref. 2; AAC23558, 3; AAC24468 and 5;
FT AAB70931)"
FT /evidence="ECO:0000305"
FT CONFLICT 314
FT /note="T -> S (in Ref. 7; AAH66202)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 397 AA; 44307 MW; BB66CEF65D32A4B9 CRC64;
MGLSWSPRPP LLMILLLVLS LWLPLGAGNS LATENRFVNS CTQARKKCEA NPACKAAYQH
LGSCTSSLSR PLPLEESAMS ADCLEAAEQL RNSSLIDCRC HRRMKHQATC LDIYWTVHPA
RSLGDYELDV SPYEDTVTSK PWKMNLSKLN MLKPDSDLCL KFAMLCTLHD KCDRLRKAYG
EACSGIRCQR HLCLAQLRSF FEKAAESHAQ GLLLCPCAPE DAGCGERRRN TIAPSCALPS
VTPNCLDLRS FCRADPLCRS RLMDFQTHCH PMDILGTCAT EQSRCLRAYL GLIGTAMTPN
FISKVNTTVA LSCTCRGSGN LQDECEQLER SFSQNPCLVE AIAAKMRFHR QLFSQDWADS
TFSVVQQQNS NPALRLQPRL PILSFSILPL ILLQTLW
