ID   GFRA4_CHICK             Reviewed;         431 AA.
AC   O93512;
DT   23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=GDNF family receptor alpha-4;
DE            Short=GDNF receptor alpha-4;
DE            Short=GDNFR-alpha-4;
DE            Short=GFR-alpha-4;
DE   Flags: Precursor;
GN   Name=GFRA4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryonic brain;
RX   PubMed=9647690; DOI=10.1006/mcne.1998.0682;
RA   Thompson J., Doxakis E., Pinon L.G.P., Strachan P., Buj-Bello A., Wyatt S.,
RA   Buchman V.L., Davies A.M.;
RT   "GFRalpha-4, a new GDNF family receptor.";
RL   Mol. Cell. Neurosci. 11:117-126(1998).
RN   [2]
RP   IDENTIFICATION OF LIGAND.
RX   PubMed=9740802; DOI=10.1016/s0960-9822(07)00422-8;
RA   Enokido Y., de Sauvage F., Hongo J.-A., Ninkina N., Rosenthal A.,
RA   Buchman V.L., Davies A.M.;
RT   "GFRalpha-4 and the tyrosine kinase Ret form a functional receptor complex
RT   for persephin.";
RL   Curr. Biol. 8:1019-1022(1998).
CC   -!- FUNCTION: Receptor for persephin. Mediates the GDNF-induced
CC       autophosphorylation and activation of the RET receptor (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC       anchor {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in muscle, kidney, brain, stomach and
CC       intestine at E6. Levels increase in the brain from E6 to E18, and
CC       decrease in muscle and intestine. Levels in the kidney remain constant.
CC       From E10, expression also found in heart, lung, skin and liver. Levels
CC       in the liver increase dramatically at E18. At E18, highest expression
CC       found in kidney and brain. In the embryonic central nervous system, the
CC       spinal cord expressed the highest levels. Lower levels found in the
CC       medulla oblongata, pons, cerebellum and midbrain, and very low levels
CC       in the forebrain.
CC   -!- SIMILARITY: Belongs to the GDNFR family. {ECO:0000305}.
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DR   EMBL; AF045162; AAC36464.1; -; mRNA.
DR   RefSeq; NP_990322.1; NM_204991.1.
DR   AlphaFoldDB; O93512; -.
DR   SMR; O93512; -.
DR   BioGRID; 676113; 1.
DR   STRING; 9031.ENSGALP00000025786; -.
DR   PaxDb; O93512; -.
DR   GeneID; 395839; -.
DR   KEGG; gga:395839; -.
DR   CTD; 64096; -.
DR   VEuPathDB; HostDB:geneid_395839; -.
DR   eggNOG; ENOG502QSGA; Eukaryota.
DR   InParanoid; O93512; -.
DR   OrthoDB; 566559at2759; -.
DR   PhylomeDB; O93512; -.
DR   PRO; PR:O93512; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR   GO; GO:0016167; F:glial cell-derived neurotrophic factor receptor activity; IBA:GO_Central.
DR   GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR   InterPro; IPR016017; GDNF/GAS1.
DR   InterPro; IPR037193; GDNF_alpha.
DR   InterPro; IPR003438; GDNF_rcpt.
DR   InterPro; IPR017372; Glial_neurotroph_fac_rcpt_a1/2.
DR   PANTHER; PTHR10269; PTHR10269; 1.
DR   Pfam; PF02351; GDNF; 3.
DR   PIRSF; PIRSF038071; GDNF_family_receptor_alpha; 1.
DR   PRINTS; PR01316; GDNFRECEPTOR.
DR   SMART; SM00907; GDNF; 3.
DR   SUPFAM; SSF110035; SSF110035; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Receptor;
KW   Reference proteome; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..403
FT                   /note="GDNF family receptor alpha-4"
FT                   /id="PRO_0000010799"
FT   PROPEP          404..431
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000010800"
FT   LIPID           403
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        180
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        296
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        308
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        339
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   431 AA;  47965 MW;  3EDD945D3CC4E71B CRC64;
     MRGILYFCTL ILLEGMAEAV SSSRDCLQAG ESCTNDPICS SKFRTLRQCI AGNGANKLGP
     DAKNQCRSTV TALLSSQLYG CKCKRGMKKE KHCLSVYWSI HHTLMEGMNV LESSPYEPFI
     RGFDYVRLAS ITAGSENEVT QVNRCLDAAK ACNVDEMCQR LRTEYVSFCI RRLARADTCN
     RSKCHKALRK FFDRVPPEYT HELLFCPCED TACAERRRQT IVPACSYESK EKPNCLAPLD
     SCRENYVCRS RYAEFQFNCQ PSLQTASGCR RDSYAACLLA YTGIIGSPIT PNYIDNSTSS
     IAPWCTCNAS GNRQEECESF LHLFTDNVCL QNAIQAFGNG TYLNAATAPS ISPTTQMYKQ
     ERNANRAAAT LSENIFEHLQ PTKVAGEERL LRGSTRLSSE TSSPAAPCHQ AASLLQLWLP
     PTLAVLSHFM M