ID   GFRP_BOVIN              Reviewed;          84 AA.
AC   Q32L41;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=GTP cyclohydrolase 1 feedback regulatory protein;
DE            Short=GFRP;
DE   AltName: Full=GTP cyclohydrolase I feedback regulatory protein;
GN   Name=GCHFR;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase
CC       1. This inhibition is reversed by L-phenylalanine (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homopentamer. Forms a complex with GCH1 where a GCH1
CC       homodecamer is sandwiched by two GFRP homopentamers. Interacts with
CC       GCH1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus membrane
CC       {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GFRP family. {ECO:0000305}.
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DR   EMBL; BC109778; AAI09779.1; -; mRNA.
DR   RefSeq; NP_001107998.1; NM_001114526.2.
DR   AlphaFoldDB; Q32L41; -.
DR   SMR; Q32L41; -.
DR   STRING; 9913.ENSBTAP00000017922; -.
DR   PaxDb; Q32L41; -.
DR   PRIDE; Q32L41; -.
DR   Ensembl; ENSBTAT00000017922; ENSBTAP00000017922; ENSBTAG00000013477.
DR   GeneID; 617650; -.
DR   KEGG; bta:617650; -.
DR   CTD; 2644; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013477; -.
DR   VGNC; VGNC:29287; GCHFR.
DR   eggNOG; ENOG502S4A0; Eukaryota.
DR   GeneTree; ENSGT00440000033849; -.
DR   HOGENOM; CLU_195651_0_0_1; -.
DR   InParanoid; Q32L41; -.
DR   OMA; GQTCIWT; -.
DR   OrthoDB; 1560576at2759; -.
DR   TreeFam; TF329303; -.
DR   Reactome; R-BTA-1474151; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000013477; Expressed in liver and 106 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0042470; C:melanosome; IEA:Ensembl.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0044549; F:GTP cyclohydrolase binding; IBA:GO_Central.
DR   GO; GO:0009890; P:negative regulation of biosynthetic process; IEA:InterPro.
DR   GO; GO:0043105; P:negative regulation of GTP cyclohydrolase I activity; IBA:GO_Central.
DR   Gene3D; 3.30.1410.10; -; 1.
DR   InterPro; IPR036717; GFRP_sf.
DR   InterPro; IPR009112; GTP_CycHdrlase_I_reg.
DR   PANTHER; PTHR16852; PTHR16852; 1.
DR   Pfam; PF06399; GFRP; 1.
DR   SUPFAM; SSF69761; SSF69761; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Membrane; Nucleus; Reference proteome.
FT   CHAIN           1..84
FT                   /note="GTP cyclohydrolase 1 feedback regulatory protein"
FT                   /id="PRO_0000317691"
SQ   SEQUENCE   84 AA;  9557 MW;  1C9925F6DEC01929 CRC64;
     MPYLLISTQI RMEVGPTVVG DEHSDPELMQ HLGASKRSVL GNNFSEYYVN DPPRIVLDKL
     ERRGFRVLSM TGVGQTLVWC LHKE