ID   GFRP_DANRE              Reviewed;          89 AA.
AC   Q6PBT6;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=GTP cyclohydrolase 1 feedback regulatory protein;
DE            Short=GFRP;
DE   AltName: Full=GTP cyclohydrolase I feedback regulatory protein;
GN   Name=gchfr;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase
CC       1. {ECO:0000250}.
CC   -!- SUBUNIT: Homopentamer. Forms a complex with GCH1 where a GCH1
CC       homodecamer is sandwiched by two GFRP homopentamers (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus membrane
CC       {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GFRP family. {ECO:0000305}.
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DR   EMBL; BC059590; AAH59590.1; -; mRNA.
DR   RefSeq; NP_957056.1; NM_200762.3.
DR   AlphaFoldDB; Q6PBT6; -.
DR   SMR; Q6PBT6; -.
DR   STRING; 7955.ENSDARP00000022896; -.
DR   PaxDb; Q6PBT6; -.
DR   Ensembl; ENSDART00000160400; ENSDARP00000135960; ENSDARG00000098588.
DR   GeneID; 393735; -.
DR   KEGG; dre:393735; -.
DR   CTD; 2644; -.
DR   ZFIN; ZDB-GENE-040426-1731; gchfr.
DR   eggNOG; ENOG502S4A0; Eukaryota.
DR   GeneTree; ENSGT00440000033849; -.
DR   HOGENOM; CLU_195651_0_0_1; -.
DR   InParanoid; Q6PBT6; -.
DR   OMA; GQTCIWT; -.
DR   PhylomeDB; Q6PBT6; -.
DR   TreeFam; TF329303; -.
DR   Reactome; R-DRE-1474151; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
DR   PRO; PR:Q6PBT6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 17.
DR   Bgee; ENSDARG00000098588; Expressed in liver and 22 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0044549; F:GTP cyclohydrolase binding; IBA:GO_Central.
DR   GO; GO:0009890; P:negative regulation of biosynthetic process; IEA:InterPro.
DR   GO; GO:0043105; P:negative regulation of GTP cyclohydrolase I activity; IBA:GO_Central.
DR   Gene3D; 3.30.1410.10; -; 1.
DR   InterPro; IPR036717; GFRP_sf.
DR   InterPro; IPR009112; GTP_CycHdrlase_I_reg.
DR   PANTHER; PTHR16852; PTHR16852; 1.
DR   Pfam; PF06399; GFRP; 1.
DR   SUPFAM; SSF69761; SSF69761; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Membrane; Nucleus; Reference proteome.
FT   CHAIN           1..89
FT                   /note="GTP cyclohydrolase 1 feedback regulatory protein"
FT                   /id="PRO_0000189678"
SQ   SEQUENCE   89 AA;  10018 MW;  09D4727471961600 CRC64;
     MPYILISTQI RLETGPTMVG DEYSDPSIMN YLGARKITVL GNNFSEYHVD EPPRLVLDKL
     DKIGYRVVSM TGVGQTLVWC LHKESSNTL