ID   GFRP_XENLA              Reviewed;          84 AA.
AC   Q6GM84;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=GTP cyclohydrolase 1 feedback regulatory protein;
DE            Short=GFRP;
DE   AltName: Full=GTP cyclohydrolase I feedback regulatory protein;
GN   Name=gchfr;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase
CC       1. {ECO:0000250}.
CC   -!- SUBUNIT: Homopentamer. Forms a complex with GCH1 where a GCH1
CC       homodecamer is sandwiched by two GFRP homopentamers (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus membrane
CC       {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GFRP family. {ECO:0000305}.
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DR   EMBL; BC074191; AAH74191.1; -; mRNA.
DR   RefSeq; NP_001086102.1; NM_001092633.1.
DR   AlphaFoldDB; Q6GM84; -.
DR   SMR; Q6GM84; -.
DR   DNASU; 444531; -.
DR   GeneID; 444531; -.
DR   KEGG; xla:444531; -.
DR   CTD; 444531; -.
DR   Xenbase; XB-GENE-6254889; gchfr.L.
DR   OrthoDB; 1560576at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 444531; Expressed in liver and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009890; P:negative regulation of biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1410.10; -; 1.
DR   InterPro; IPR036717; GFRP_sf.
DR   InterPro; IPR009112; GTP_CycHdrlase_I_reg.
DR   PANTHER; PTHR16852; PTHR16852; 1.
DR   Pfam; PF06399; GFRP; 1.
DR   SUPFAM; SSF69761; SSF69761; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Membrane; Nucleus; Reference proteome.
FT   CHAIN           1..84
FT                   /note="GTP cyclohydrolase 1 feedback regulatory protein"
FT                   /id="PRO_0000189679"
SQ   SEQUENCE   84 AA;  9563 MW;  A7A4968BAC65D118 CRC64;
     MPYVLISTQI RMETGPTIVG DEFSDLVLMA QLEADKRTVL GNNFSEYYVN EPPRVTLNKL
     ERLGYRVVSM TGVGQTLVWC LHKE